Project summary
Nausea is an unpleasant sensation of visceral malaise often accompanied by an involuntary urge to vomit.
Nausea responses to toxin ingestion and infection are evolutionarily beneficial survival behaviors that
avoid or expel toxins which may cause peripheral tissue damage.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleMolecular and circuit mechanisms of nausea-associated behaviors
Investigator
Chuchu Zhang
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
TitleMolecular and sensory foundations of vestibular reflex circuit assembly in the larval zebrafish
Investigator
Dena Goldblatt
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY: Behavioral dysfunction in neurodevelopmental diseases often arises from aberrant
neural circuit assembly. However, the developmental logic that dictates circuit organization, function, and
ultimately behavior remains unresolved due to the complexity of most circuits.
TitleMotor Recovery through Plasticity-Inducing Cortical Stimulation
Investigator
Steven C. Cramer, Jeffrey G Ojemann
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Limited recovery of function after stroke remains a major problem for millions. Disability persists in
many, especially when hand function is limited. Existing therapies are limited and many have difficulties with
activities of daily living, even after rehabilitation.
TitleMulti-probe minimally invasive endomicroscope
Investigator
Antonio Miguel Caravaca Aguirre
Institute
modendo inc.
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
This project seeks to develop a multi-probe ultrathin endomicroscope to enable high-resolution imaging and
photo-stimulation at multiple sites within currently inaccessible regions of the brain.
TitleMultimodal dissociation of posterior cingulate cortex contributions to episodic memory
Investigator
Seth Ryan Koslov
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Episodic memory is the ability to recall details about prior experiences. Researchers have historically relied on
controlled item-recognition paradigms, in complement to autobiographical recall tasks, to investigate the
biological substrates of episodic memory.
TitleNetwork based neuro-modulation for mesial temporal lobe epilepsy
Investigator
Behnaam Aazhang, Sandipan Pati Bankim Behari Pati, Nitin Tandon, Gregory A Worrell
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
TitleNeural basis of facial individual recognition in paper wasps
Investigator
Michael J Sheehan
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
The neural circuits of animals, including humans, are the combined product of adaptation by natural selection
and the evolutionary history of a species.
TitleNeural circuit mechanisms for multisensory associative learning
Investigator
Roudabeh Behnia, Ashok Litwin-Kumar
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The brain uses sensory representations to assess risk and predict reward in order to adjust behavior. Per
ception is a multisensory process. To make reliable predictions, it is advantageous for the brain to combine
more than one sensory modality to represent the world.
TitleNeural coding of natural stimuli in freely moving macaque
Investigator
Valentin Dragoi
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
Despite the fact that visual perception represents such a fundamental aspect of our everyday life, our knowledge
of the underlying neural coding of natural stimuli is woefully lacking.
TitleNeural mechanisms of behavioral coordination in Hydra
Investigator
Alison Hanson
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
How do animals coordinate their many parts to generate coherent, adaptive behavior?
TitleNeural mechanisms of taste and metabolic state integration in the brainstem
Investigator
Nilay Yapici
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The taste of food is a critical factor that determines whether an organism will accept or reject a food source.
TitleNeuro-flakes: Direct Voltage Imaging of Neural Activity with Atomically-thin Optoelectronic Materials
Investigator
Ertugrul Cubukcu
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Neuro-flakes: Direct Voltage Imaging of Neural Activity with Atomically-thin
Optoelectronic Materials
Recording electrical activity of neural populations with high resolution is essential to
investigate neural circuits and cognitive functions.
TitleNEURODEVELOPMENTAL FUNCTION OF HCFC1
Investigator
Victoria L Castro
Institute
university of texas el paso
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Mutation of HCFC1 causes a multiple congenital anomaly syndrome characterized by inborn errors of cobalamin
metabolism, intractable epilepsy, intellectual disability, and motor dysfunction.
TitleNeurodevelopmental role of a tRNA methyltransferase underlying intellectual disability
Investigator
Kimberly Rose R. Madhwani
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Gene regulation at multiple levels is critical for nervous system development and function.
TitleNeurostimulation of the Nucleus Basalis of Meynert for the cognitive-motor syndrome in Parkinson's disease
Investigator
Helen Bronte-Stewart
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Cognitive decline begins in early stages of Parkinson’s disease (PD) and progresses to dementia in 75% of
people with PD after ten years.
TitleNew Methodologies for Connectomics
Investigator
Xiaotang Lu
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT ABSTRACT
The nervous systems of animals are comprised of neurons connected by a large number of synapses.
The resulting neural networks underlie animal behavior and contribute to the storage of learned
information in many species.
TitleONIX: A Neural Acquisition System for Unencumbered, Closed-Loop Recordings in Small, Freely Moving Animals
Investigator
Jonathan Newman
Institute
open ephys, inc
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Over the last century, extracellular recording technologies have progressed from handmade needle electrodes
and vacuum tube amplifiers to microfabricated devices containing hundreds of recording sites and on-chip
digitization circuits.
TitleOpen-source miniaturized two-photon microscopes for large field-of-view and volumetric imaging
Investigator
Daniel Aharoni, Hugh T Blair, Anne Kathryn Churchland, Peyman Golshani, Alcino J. Silva, Alipasha Vaziri
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Abstract:
Single-photon (1P) epifluorescence miniaturized microscopy coupled with genetically encoded calcium sensors
has allowed investigators to record the activity of large populations of identified neurons over days to weeks in
freely behaving animals, answering fundamental questions in neurosci
TitleOptical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation
Investigator
Xue Han
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation Deep brain stimulation (DBS) directly stimulates brain tissue via implanted electrodes.
TitleOptimization of Calcium and RNA multiplexed activity imaging for highly parallelized evaluation of cell type functions in deep-brain structures
Investigator
Meng Cui, Scott M Sternson
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A central goal of neuroscience is to understand animal behavior in the context of the information processing properties of neuron ensembles.