PROJECT SUMMARY Sensory representations are influenced by an animal’s external context, internal state, past experiences, expectations, and future goals.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Cell type-specific mechanisms of history-dependent perceptual biases in sensory cortex
Investigator
Deepa L Ramamurthy
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
Title
Center for Advanced Muscle BioElectronics (CAMBER)
Investigator
Muhannad Bakir, Samuel Sober
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
A central goal of neuroscience is to discover how neural circuits control the body’s muscles to produce behavior.
Title
Characterizing Lower Extremity Neurophysiological Responses to Sensory Augmentation after Stroke
Investigator
Jasmine Jamilah Cash
Institute
medical university of south carolina
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT After a stroke, walking ability can be compromised, which can lead to reduced quality of life and decreased ability to perform activities of daily living.
Title
Circuit mechanisms of arbitration between distinct reinforcement learning systems
Investigator
Margaret Louise Demaegd
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Animals can exhibit goal-directed behaviors in novel environments, despite limited experience with them. How does the brain make and use inferences about the underlying statistics and generative structure of environments to guide behavior?
Title
Circuit-specific, chemogenetic neuromodulation in nonhuman primates.
Investigator
Serge E Przedborski, Charles E Schroeder
Institute
nathan s. kline institute for psych res
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT ‒ UG3/UH3 Deep Brain Stimulation (DBS), applied to areas like the subthalamic nucleus (STN), is a standard treatment for Parkinson Disease (PD), however, DBS has inherent surgical risks as well as potential for infections and adverse side effects.
Title
cloudSLEAP: Maximizing accessibility to deep learning-based motion capture
Investigator
Talmo D. Pereira
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
cloudSLEAP – PROJECT SUMMARY/ABSTRACT Understanding how the brain produces complex behavior is a central goal of neuroscience, but quantifying behavior is technically challenging, particularly in unrestrained and naturalistic settings.
Title
Cognitive and Neural Strategies for Latent Feature Inference
Investigator
Tahra Eissa
Institute
university of colorado
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The world around us has a statistical structure that we can use to improve our choices. Learning the underlying structure by identifying key features, such as the rate of change, is useful for adapting and optimizing our decision-making strategies.
Title
Commercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits
Investigator
Rajmohan Bhandari, Cynthia Anne Chestek, Daniel Powell, Florian Solzbacher
Institute
blackrock microsystems
Fiscal Year
Funding Opportunities Number
Project Number
The ability to measure and manipulate local brain circuit activity in living, behaving animals is essential to understanding the complexities of brain function and dysfunction.
Title
Continuous development of nTracer2 and its deployment at NIH image repositories
Investigator
Dawen Cai, Yan Yan
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Abstract In response to the BRAIN Initiative “Integration and Analysis of BRAIN Initiative Data” FOA, we propose further developing nTracer2, a cloud-based platform for brain image visualization and neuron tracing in the web browser.
Title
DDALAB: Identifying Latent States from Neural Recordings with Nonlinear Causal Analysis
Investigator
Terrence J Sejnowski
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Summary The goal of this proposal is to develop DDALAB, a software platform that will make it possible for researchers to identify latent cortical states and analyze the flow of information in large populations of neurons using Delay Differential Analysis (DDA).
Title
Developing novel neural network tools for accurate and interpretable dynamical modeling of neural circuits
Investigator
Christopher Versteeg
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract In recent years, the number of neurons that we can record simultaneously has seen an exponential increase, presenting a daunting challenge: how do we analyze these complex and high-dimensional datasets to gain insight into how neural circuits perform computation?
Title
Development and In Vivo Validation of a Theoretical Framework and Practical Methods to Improve Safety and Efficacy of Neuromodulation Electrodes
Investigator
Kip A Ludwig
Institute
university of wisconsin-madison
Fiscal Year
Funding Opportunities Number
Project Number
Despite widespread clinical use, the theoretical framework by which to understand safety of electrical stimulation through implanted electrodes is surprisingly limited.
Title
Dissemination of the Human Neocortical Neurosolver (HNN) software for circuit level interpretation of human MEG/EEG
Investigator
Stephanie Ruggiano Jones
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
HNN U24 DISSEMINATION PROJECT SUMMARY The Human Neocortical Neurosolver (HNN) neural modeling tool was developed with BRAIN Initiative funding (R01EB022889: 09/2016–06/2020) to meet the Initiative’s goal to “develop innovative technologies to understand brain circuits and ensembles of circuits th
Title
ENABLING SUBMILLISECOND-TIMESCALE TWO-PHOTON RECORDING OF VOLTAGE DYNAMICS IN THREE DIMENSIONS IN VIVO
Investigator
Laurent Bourdieu, Francois St-Pierre
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Because neurons integrate and process information via modulation of their membrane potential, the ability to monitor voltage is critical to understanding how single and groups of neurons compute.
Title
Extending ezBIDS, NiiVue and dcm2niix for user-friendly cloud-based integration and visualization
Investigator
Christopher Rorden
Institute
university of south carolina at columbia
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract Cloud-based analyses and easily shared data formats are revolutionizing neuroimaging. We will develop software to fill gaps created by these two trends. We will develop and refine software to visualize and analyze the data from the BRAIN Initiative.
Title
Functions of the Cortical Amygdala in social behavior
Investigator
Antonio V Aubry
Institute
icahn school of medicine at mount sinai
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In most cases, aggression is a necessary, adaptive component of social behavior.
Title
High-throughput 3D mapping of large mammalian brains via integration of precision tissue sectioning and light sheet imaging
Investigator
Ji Wang, Nicholas Bruce Evans, Hsuan Lee, Jeffrey Stirman
Institute
lifecanvas technologies, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Whole-brain mapping at the cellular and subcellular levels is crucial to systematically understand brain functions and disorders.
Title
Identifying human-specific neural progenitors and their role in neurodevelopment
Investigator
Sumin Jang
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Humans have highly advanced cognitive abilities and motor skills, characteristics which are reflected in the enlarged size and cell diversity of our central nervous system (CNS).
Title
Identifying the neural mechanisms of goal-directed decision-making in Parkinson's disease using closed-loop deep brain stimulation
Investigator
Colin Hoy
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
TITLE: IDENTIFYING THE NEURAL MECHANISMS OF GOAL-DIRECTED DECISION-MAKING IN PARKINSON’S DISEASE USING CLOSED-LOOP DEEP BRAIN STIMULATION PROJECT SUMMARY People with Parkinson’s disease commonly suffer from non-motor symptoms, including motivation deficits, that impact quality of life more than c
Title
Implications of Prefrontal Cortex Development for Adolescent Reward Seeking Behavior
Investigator
Gabriela Manzano Nieves
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY As we get older, we learn to modulate our behaviors to optimize reward outcomes. These adaptive choices are orchestrated by current sensory conditions, internal cognitive states, and future expectations.