Funded Awards

Fast glutamatergic synaptic transmission is based on a precise and complex molecular organization which requires the control of the number of AMPA-type glutamate receptors (AMPARs) at the postsynaptic sites of glutamatergic synapses on dendritic spines.

A brief glimpse at a face quickly reveals rich multi-dimensional information about the person in front of us. How is this impressive computational feat accomplished? A recently revised neural framework for face processing suggests perception of face form information, i.e.

The ability to listen and identify sounds in the presence of competing background noise is a critical function of the healthy auditory system.

PROJECT SUMMARY/ABSTRACT In order to understand neurological diseases, it is essential to identify the affected neuronal cell types, create model systems that accurately recapitulate normal function and disease phenotypes, and develop tools that allow cellular manipulations.

PROJECT SUMMARY Tourette syndrome (TS) is a continuous lifelong condition that is highly prevalent, socially disabling, and in some severe cases, physically injurious.

ABSTRACT Understanding the biological principles of cell type diversity and organization is necessary for deciphering neural circuits underlying brain function.

Project Summary This application describes a 5-year plan to investigate the neural dynamics that underpin distortion in memory, integrating computational modeling approaches with functional neuroimaging (fMRI) and non-invasive brain stimulation techniques (TMS).

Measurements of cortical field potentials are widely used throughout basic and clinical neuroscience, including in electroencephalography (EEG), electrocorticography (ECoG) and local field potential (LFP) recordings.

PROJECT SUMMARY Insufficient sleep, sleep disorders, and resulting problems with health and cognition are increasingly common in the United States.

Project Summary/Abstract Electromagnetic brain stimulation is a safe and proven way of controlling neural activity non-invasively with no implanted hardware or injected biochemical agents.

Project Summary Brain-computer interfaces (BCIs) have emerged as a promising modality for restoring physiological functions such as mobility, communication, and visual perception.

PROJECT SUMMARY/ABSTRACT The growing availability of large functional magnetic resonance imaging (fMRI) datasets has enabled new investigations into functional systems of the human brain.

Project Summary A prominent feature of biological neuronal networks is the astonishing diversity of their cell types.

Project Summary The goal of this project is to create a unified framework for understanding the relationship between neuronal gene expression and connectivity in mouse visual cortex, by using morphology as a key linking modality.

Project Abstract The first postnatal years are an exceptionally dynamic and critical period of structural and functional development of the human brain. Many neurodevelopmental disorders are the consequence of abnormal brain development during this stage.

The human brain is an unimaginably complicated system of interconnected neurons that is capable of complex thought, emotion and behavior.

PROJECT SUMMARY Serotonin has been long been recognized as an important modulator of mood and behavior, yet it projection- specific dynamics are little understood.

Constructing an integrated picture of human brain function requires understanding how the effects of molecular and genetic factors propagate upwards, through many intervening layers of structure and interaction, to influence behavioral, psychiatric and cognitive traits.

SUMMARY Brain-mapping initiatives are acquiring increasingly large and comprehensive neuroimaging and multiomic— e.g. genomic and transcriptomic—datasets.

Project Summary Intracranial electrical brain stimulation (EBS) remains a central method in the clinic as well as for research in several animal model systems. However, little is actually known about the ensembles of neurons activated by typical and clinical intracranial EBS protocols.