Abstract
This application will combine the strengths of two large scale NIH-funded initiatives to understand disorder-
related patterns in the human brain: Connectomes Related to Human Disease (CRHD) and Enhancing
Neuroimaging Genetics through Meta-Analysis (ENIGMA).
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleRedefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine Learning
Investigator
Peter V. Kochunov, Paul M Thompson
Institute
university of maryland baltimore
Fiscal Year
Funding Opportunities Number
Project Number
TitleResolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space Methods
Investigator
Genevieve Lauren Stein-O'brien
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
High-throughput profiling of hundreds of thousands of cells in the central nervous system (CNS) is currently
underway.
TitleResource Core 3 - Teaching/Training/Dissemination Core (TTDC)
Investigator
Maisie Ky Lo
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Resource Core 3 - Teaching/Training/Dissemination Core (TTDC)
Leads: Maisie Lo PhD and Kristin Overton PhD
Summary
The TTDC’s teaching mission specifically leverages our educational infrastructure for advancing the
application of modern neurotechnology methods in short (3-day) or extended-format (
TitleRobust modeling of within- and across-area population dynamics using recurrent neural networks
Investigator
Lee Miller, Chethan Pandarinath
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
Over the past several decades, the ability to record from large populations of neurons (e.g., multi-electrode
arrays, neuropixels, calcium imaging) has increased exponentially, promising new avenues for understanding
the brain.
TitleScalable tools for consistent identification of neuronal cell types in mouse and human
Investigator
Staci A Sorensen, Uygar Sumbul
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The proposed work will address a critical gap in our understanding of neuronal phenotypes and cell types by
developing machine learning algorithms and cloud-based software for the integration of multiple modality
characterizations large and growing datasets of cortical neurons in mou
TitleSecondary analysis of functional MRI and resting state connectivity in white matter
Investigator
John C Gore, Bennett A. Landman
Institute
vanderbilt university medical center
Fiscal Year
Funding Opportunities Number
Project Number
Abstract / Summary
This proposal aims to perform novel, secondary analyses on large archives of publicly-available fMRI
studies in order to quantify the functional characteristics of white matter (WM) and their changes during
normal aging and in the progression to Alzheimer’s Disease (AD).
TitleSex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding
Investigator
Brandy A. Briones
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This proposal seeks to investigate sex hormone effects on reward and aversion-related behaviors through
mapping of Lateral Habenula (LHb) circuits.
TitleStimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI.
Investigator
Daniel Lu
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Respiratory failure after spinal cord injury (SCI) impairs the health of the injured patients, and respiratory failure
is the leading cause of death in patients with SCI.
TitleStructure and function of spontaneous network activity during circuit formation
Investigator
Arnaldo Carreira-Rosario
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Towards the end of nervous system development, neural circuits are extremely plastic. Small perturbations
during this time can cause lifelong circuit and behavioral changes.
TitleThalamocortical Responsive Neurostimulation for the Treatment of Lennox-Gastaut Syndrome
Investigator
Martha J Morrell
Institute
neuropace, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Lennox-Gastaut Syndrome (LGS) is a devastating form of childhood onset epilepsy with cognitive
dysfunction and very frequent generalized onset seizures (GOS) often leading to injury.
TitleThe representation and modulation of sensory information in the learning and memory center of the Drosophila brain
Investigator
Andrew M Davidson
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
The brain uses the combined physiology of many cells to transform incoming sensory signals into internal
representations.
TitleThe role of astrocyte-neuron signaling in closing a critical period required for motor circuit structure, function, and behavior
Investigator
Sarah D Ackerman
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Significance: Neural circuit assembly requires activity-dependent refinement of circuit architecture (e.g.
plasticity) to produce stereotyped behavior.
TitleToward functional molecular neuroimaging using vasoactive probes in human subjects
Investigator
Alan Jasanoff
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
We propose to develop a probe technology for monitoring human brain function with molecular precision;
in conjunction with magnetic resonance imaging (MRI) or other imaging modalities, the probes will provide a
combination of sensitivity and resolution that could permit unprecedented noninvasive stu
TitleUnderstanding the regulation of neuron cell number and arbor size
Investigator
Jennifer A Malin
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
How the brain generates the correct number of neurons and how these neurons determine the size of their
arbors to innervate the receptor field is a critical question in neurobiology.
TitleUse of advanced analytics to understand brain-behavior screen media activity relationships in ABCD data
Investigator
Marc N Potenza, Yihong Zhao
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Growing up in a media-saturated world, the current generation of children and adolescents spend on average 6-
9 hours each day on screen media activities (SMAs). Therefore, SMA is a topic of considerable concern in the
USA and elsewhere.
TitleUsing large scale electrophysiology to study the role of midbrain dopamine neurons underlying motivated behaviors
Investigator
Kurt M Fraser
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A core feature of a number of psychiatric illnesses is the disordered estimation of the predictive relationship
between a given cue and an outcome. This failure to appraise and generate appropriate behavioral responses
is true for cues that both are rewarding and aversive.
TitleWaking up the nervous system: Molecular characterization of neuronal leader cells and their role in brain development
Investigator
Nicole Ann Aponte-Santiago
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Learning how spontaneous neuronal activity shapes embryonic brain development is critical for understanding
neurodevelopmental processes, with implications in neurological or neuropsychiatric disorders.
Title4D Transcranial Acoustoelectric Imaging for High Resolution Functional Mapping of Neuronal Currents
Investigator
Russell S Witte
Institute
university of arizona
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The overarching goal of this project is to optimize, validate and implement a revolutionary and safe modality
for noninvasive functional imaging of neural currents deep in the human brain through the skull at
unprecedented spatial and temporal resolution.
TitleA Community Framework for Data-driven Brain Transcriptomic Cell Type Definition, Ontology, and Nomenclature
Investigator
Michael Hawrylycz, Ed Lein, Christopher J Mungall, Helen Elizabeth Parkinson, Richard H Scheuermann
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: A Data-driven Framework for Brain Transcriptomic Cell Type Definition, Ontology, and
Nomenclature
Defining the complete census of neuronal and non-neuronal cell types in the brain is a major priority for the NIH BRAIN
Initiative, since cellular complexity is a major barrier to under
TitleA Comparative Framework for Modeling the Low-Dimensional Geometry of Neural Population States
Investigator
Eva Dyer
Institute
georgia institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Advances in neural recording technology now provide access to neural activity at high temporal resolutions, from
many brain areas, and during complex and naturalistic behavior.