Project Summary / Abstract
The long-term goal of my research is to gain a holistic understanding of how movement commands are
generated- including their relationship to sensory feedback and movement context- in order to restore movement
to those who have lost it.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleDecision-related information at single-neuron resolution in human motor cortex and its implications for neuroprosthetics
Investigator
Sharlene Flesher
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
TitleDefining the role of a prefrontal-midbrain circuit in exploratory behavior
Investigator
Victoria L Corbit
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Investigating how neural circuits mediate natural behavior is a critical to our understanding of the brain.
Exploratory behaviors are necessary for rodent survival in the natural world and ubiquitous in freely-moving
rodent experiments.
TitleDevelopment of the Human Dynamic Neurochemical Connectome Scanner
Investigator
Ciprian Catana
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We seek support to develop and build the next generation 7-Tesla magnetic resonance (MR)-compatible
positron emission tomography (PET) brain scanner with dramatically improved spatiotemporal resolution
(HSTR-BrainPET).
TitleDissecting the neural circuit for discrete cue representation in the Dentate Gyrus
Investigator
Sebnem Nur Tuncdemir
Institute
new york state psychiatric institute dba research foundation for mental hygiene, inc
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to provide the building blocks for an independent research program focused on
the mechanisms by which neural networks incorporate multisensory cues into episodic memories.
Discrimination of different contexts composed of distinct constellations of multisensory cues is a h
TitleDopamine neuronal microcircuits controlling methamphetamine seeking behavior
Investigator
Sergio Dominguez Lopez
Institute
oklahoma medical research foundation
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
This proposal is being submitted to support the transition of Dr. Dominguez-Lopez from mentored trainee to
an independent investigator in the neurobiology of drug addiction, specifically studying the dopamine
microcircuits controlling drug-seeking behavior. Dr.
TitleDynamic Striatal Astrocyte-Neuron Interactions: An Integrated Experimental and Computational Study
Investigator
Marsa Taheri
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Astrocytes comprise up to half of mammalian brain cells.
TitleElucidating electrical stimulation induced non-neuronal activity using emerging in vivo imaging technology and electrophysiology
Investigator
Takashi Daniel Yoshida Kozai
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Electrical microstimulation has become a mainstay of fundamental neuroscience exploration and an
increasingly prevalent clinical therapy.
TitleEthics of the Choice of Invasive versus Non-invasive Neurosurgery: Different Stakeholders' Perspectives, Surgical Decision-making, and Impact on Patient Sense of Control
Investigator
Cynthia M. S. Kubu
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A fundamental ethical tenet in medicine is bodily sovereignty, inherent in which is the concept of
control.
TitleGenetic mechanisms specifying astrocyte functional diversity and their role in sleep
Investigator
Margaret Ho
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Astrocytes are evolutionarily conserved and constitute a substantial proportion of the cells in the brain, yet our
understanding of their identities and functions is far less comprehensive than for neurons.
TitleGraspy: A python package for rigorous statistical analysis of populations of attributed connectomes
Investigator
Carey Priebe, Joshua T Vogelstein
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Overview: We will extend and develop implementations of foundational methods for analyzing populations of
attributed connectomes.
TitleHighly Portable and Cloud-Enabled Neuroimaging Research: Confronting Ethics Challenges in Field Research with New Populations
Investigator
Frances Patricia Lawrenz, Francis X Shen, Susan M. Wolf
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
This 4-year Neuroethics R01 based at the University of Minnesota (UMN) will convene a national
Working Group of top neuroethics, neurolaw, and neuroscience experts to conduct empirical research and
generate evidence-based consensus recommendations for the ethical conduct
TitleHormonal regulation of value-based decision-making
Investigator
Carla Golden
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Individuals decide between alternatives based on their perceived value of the reward associated with each
option.
TitleIdentifying mediators of sex hormone uptake and signaling
Investigator
Nicole Yishi Leung
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Sex hormones are critical for sexual differentiation of the brain and body and diverse physiological processes
across our lifespan.
TitleImproving Brain Organoid Models by Mediating Metabolic Dysregulation
Investigator
Madeline Andrews
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
There is currently an unmet need for accurate model systems of the human brain to study its cellular and
molecular features.
TitleInnovative biostatistical approaches to network level analyses of connectome-behavior relationships
Investigator
Muriah D Wheelock
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Determining the mechanisms by which the human brain generates cognition, perception, and emotion hinges
upon quantifying the relationships between coordinated brain activity and behavior.
TitleInter-System Closed-Loop Control of Locomotor and Bladder Function in Individuals with Acute Spinal Cord Injury
Investigator
Claudia Angeli, Maxwell Boakye
Institute
university of louisville
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY ABSTRACT
More than 1.2 million people in the United States have a spinal cord injury (SCI), and each year there are 10,000
new cases.
TitleInvestigation of the Cortical Communication (CORTICOM) System
Investigator
Nathan E Crone, Nicolas Franciscus Ramsey
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
For many years brain-computer interfaces (BCI's) have been explored as a means of restoring communication
to patients with Locked-In Syndrome (LIS), a devastating and often irreversible neurological condition in which
cognition is intact but nearly all motor output from the brain is interrupted, eff
TitlekHz frequency Spinal Cord Stimulation: Novel Temperature-Based Mechanisms of Action
Investigator
Marom Bikson
Institute
city college of new york
Fiscal Year
Funding Opportunities Number
Project Number
Project(Summary(/(Abstract!
There is a need to understand the mechanisms of neural stimulation technologies (RFA-NS-18-018). The impact
of such research increases with both the clinical relevance of a neuromodulation technology and the extent
mechanisms are unknown.
TitleLarge-scale monitoring of circuits for adaptation and novelty detection in primary visual cortex
Investigator
Jordan Marie Ross
Institute
georgia state university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
In a world filled with sensory information, the ability to filter out repetitive or redundant stimuli while still
maintaining the ability to detect change in the environment is critical to biological success.
TitleLateral habenula circuit in reward/conflict mediation
Investigator
Christian Emmanuell Bravo-Rivera
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Reward is often present in risky environments, requiring individuals to weigh the benefits of rewards against
the associated risks. There are several psychiatric disorders in which patients are unable to choose an
appropriate response during risky reward opportunities.