PROJECT SUMMARY
Stroke is the leading cause of motor disability in the United States. While brain stimulation to enhance motor
function after stroke has shown promise in small studies, two recent large stroke trials did not find evidence for
significant benefits.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleOptimizing oscillatory epidural electrical stimulation to selectively increase task-related population dynamics in motor areas
Investigator
Karunesh Ganguly, Jeffrey A Roberts
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
TitlePrefrontal contributions to contextual representation
Investigator
Cybelle Marguerite Smith
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract/Summary
This application describes a 3-year training plan that will enable me, a cognitive neuroscientist with prior
training in electroencephalography (EEG), to conduct research on contextual memory representation using
neuroimaging (fMRI) and computational modeling.
TitleReal-time manipulations to understand and improve memory processes
Investigator
Anna Kathleen Gillespie
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The hippocampus is critical for capturing rich, multimodal representations of experience and facilitating
the long-term storage and later recall of these experiences.
TitleRelating structure and function in synapse-level wiring diagrams
Investigator
Ashok Litwin-Kumar
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project summary:
Modern electron-microscopy (EM) imaging and analysis methods now permit the comprehensive reconstruction
of all neurons and synapses in large volumes of brain tissue or the entire brains of individual organisms. However,
relating this structure to function is difficult.
TitleRestoring Sight to the Blind: Neural Imaging with Retinal Prostheses
Investigator
Noelle Stiles
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary – Restoring Sight to the Blind: Neural Imaging with Retinal Prostheses
Retinal prostheses restore sight to the blind by electrically stimulating still viable cells in the
retina.
TitleSignificance of excitatory and inhibitory synaptic integration by interneurons for local circuit dynamics and behavior
Investigator
Brandon David Turner
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Localized structuring of neuronal output by inhibitory microcircuits is a fundamental component of
neuronal information processing.
TitleStudying how the hippocampal-prefrontal-hypothalamic circuit encodes social dominance
Investigator
Nancy Padilla Coreano
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Social deficits are common in psychiatric disorders and available treatments are limited. Our lack of basic
knowledge on how the brain controls social behaviors makes it challenging to develop therapeutics for social
deficits.
TitleThe behavioral microstructure of a memory-guided food-caching behavior and its relationship to hippocampal replay
Investigator
Selmaan Chettih
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The hippocampus is a critical site for rapid memory formation and retrieval, with extensively documented
functions representing spatial and navigational variables, yet less is known of the means by which it guides
behavior.
TitleThe experience of human subjects with brain organoid research
Investigator
Kate E. Macduffie
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Efforts to understand the mechanisms of brain-based disease have been hindered by the limited
ability of animal models to reflect the full complexity of human brain and behavior.
TitleThe Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function
Investigator
David A Boas, Swathi Kiran
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Innovations in human neuroimaging tools have driven profound advances in our understanding
of brain function under well-controlled and constrained conditions.
TitleThe planning of new compositional action sequences guided by interpretation of ambiguous sensory data in a novel drawing task
Investigator
Lucas Y. Tian
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Animals exhibit a remarkable array of creative, adaptive, and flexible behaviors.
TitleTracking Changes in High-Dimensional Circuit Behaviors over Long-Term Neural Recordings
Investigator
Alexander Henry Williams
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Recent breakthroughs in neural recording technologies suggest the possibility of understanding the
collective dynamics of large-scale brain circuits.
TitleUsing multiple species, stimuli, and tasks to study the neural basis of visually guided behavior
Investigator
Amy Meesun Ni
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The visual system must constantly extract behaviorally relevant stimulus information from an abundance of
irrelevant inputs from the environment, using cognitive phenomena such as attention and learning to guide this
continuously adapting process.
TitleUsing perceptual decision-making to understand the role of selective inhibitory activity in cortical computation
Investigator
James Patrick Roach
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Cortical circuits perform computations to generate appropriate behaviors based upon diverse
sensory inputs. These computations are central to an animal maintaining its health and long-
term survival.
Title4D Transcranial Acoustoelectric Imaging for High Resolution Functional Mapping of Neuronal Currents
Investigator
Russell S Witte
Institute
university of arizona
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The overarching goal of this project is to develop, validate and implement a new modality for noninvasive
functional imaging of neural currents deep in the human brain through the skull at unprecedented spatial and
temporal resolution.
TitleA data science toolbox for analysis of Human Connectome Project diffusion MRI
Investigator
Ariel Shalom Rokem
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The connections between different brain regions play an important role in normal brain function. This project
proposes to create an end-to-end pipeline for analysis of human white matter connections using “tractometry”
methods.
TitleA Technology Resource for Polymer Microelectrode Arrays
Investigator
Ellis Meng, Dong Song
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
The purpose of this proposal is to disseminate polymer microelectrode arrays and promote their
integrated into neuroscience research practice.
TitleA unified framework to study history dependence in the nervous system
Investigator
Fidel Santamaria
Institute
university of texas san antonio
Fiscal Year
Funding Opportunities Number
Project Number
The brain uses its own previous activity to adapt to an ever-changing environment. This history
dependent adaptation takes place at all scales of organization of the nervous system.
TitleA wearable functional-brain-imaging system with full-head coverage and enhanced spatiotemporal-resolution to study complex neural circuits in human subjects
Investigator
Peter D. D. Schwindt
Institute
sandia corp-sandia national laboratories
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
To develop maps at multiple scales of neuronal circuits in the human brain and study the brain dynamics, there
is a need for non-invasive functional brain imaging with high spatiotemporal resolution operating in natural
environments.
TitleAccurate and reliable computational dosimetry and targeting for transcranial magnetic stimulation
Investigator
Luis Javier Gomez
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Transcranial magnetic stimulation (TMS) is a noninvasive technique used for neuroscience research and
treatment of psychiatric and neurological disorders. During TMS, a current-carrying coil placed on the scalp
induces an electric field that modulates targeted neuronal circuits.