This proposed project focuses on quantifying the spatial and temporal diversity in cortical oxygen metabolism and neurovascular coupling, and informing next generation of biophysical models of the Blood Oxygen Level Dependent (BOLD) functional Magnetic Resonance Imaging (fMRI) measurements by integr
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleEffects of standard fMRI calibrations on the diverse microvascular blood flow and oxygenation responses in cortical layers
Investigator
Ikbal Sencan-Egilmez
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
TitleEfficiency and Safety of Microstimulation Via Different Electrode Materials
Investigator
Xinyan Tracy Cui
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Microstimulation has been an invaluable tool for neuroscience researchers to infer functional connections
between brain structures or causal links between structure and behavior.
TitleEfficient resource allocation and information retention in working memory circuits
Investigator
Shinung Ching, Lawrence H Snyder
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Short-term working memory is critical for all cognition. It is important to fluid intelligence by definition and is
disordered in many psychiatric conditions. It is also an ideal model system for studying the link between the
dynamics and functions of neural circuits.
TitleExpanding access to open-source data acquisition software for next-generation silicon probes
Investigator
Joshua H Siegle
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
We plan to provide software support services for Neuropixels probes, a groundbreaking new tool for recording
electrical signals from the brain.
TitleFunctional implications of a patch/matrix-like compartmental organization in the mouse inferior colliculus
Investigator
Alexandria Marie Lesicko
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A major unresolved question in systems neuroscience is whether specialized anatomical structures support
specific functions in behavior. Therefore, this proposal will bridge the gap between anatomical circuit diagrams
and their predicted functional roles.
TitleGenerating a formal set of collaborative standards for sharing behavioral data and task designs to enable reproducibility in neuroscience
Investigator
Stephen Anthony Edwards, Adam Kepecs
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The goal of this project is to develop an archival data format and a formal task specification
language to serve as standards for describing behavioral experiments.
TitleHigh-density microgrid development for human neural interface devices
Investigator
Daniel R Cleary
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Brain-computer interfaces (BCI) offer hope to treat otherwise intractable neurological disease. However, the
current state of BCI is still short of the potential; solutions to fundamental biological and engineering problems
must be found before BCIs can be broadly used for patient care.
TitleInput-specific imaging and manipulation of synaptic plasticity underlying social memory
Investigator
Mary L Phillips
Institute
max planck florida corporation
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Ascertaining the neural basis of behavior has been a cornerstone goal since the conception of neurobiology.
While activity recording and loss-of-function studies have shed light on brain regions involved and necessary for
the expression of certain behaviors, they are unabl
TitleIntegrated Biophysical and Neural Model of Electrical Stimulation Effects
Investigator
Maksim V Bazhenov, Eric Halgren
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Electrical stimulation is widely used to activate and/or disrupt neuronal activity.
TitleIntercellular TWEAK/Fn14 Cytokine Signaling in Sensory-Dependent Circuit Refinement
Investigator
Lucas M Cheadle
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
During postnatal brain development, newly assembled neural circuits are refined through the strengthening of a subset of synaptic connections and the concurrent elimination of others.
TitleInterneurons differentially regulate discrete pathways from ventral hippocampus
Investigator
Jennifer Donegan
Institute
university of texas hlth science center
Fiscal Year
Funding Opportunities Number
Project Number
Hippocampal microcircuits are comprised of excitatory pyramidal cells, which integrate information and innervate
downstream brain regions, and inhibitory interneurons, which function locally to regulate pyramidal cell activity
and synchronicity.
TitleInterrogating Biophysical Mechanisms of Magnetogenetic Cell Stimulation at Radio Frequencies
Investigator
Chunlei Liu
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Magnetogenetics is a recently proposed method for stimulating cells using electromagnetic fields. In one
approach, radio-frequency (RF) electromagnetic fields are applied to stimulate membrane channel proteins such
as TRPV1 and TRPV4 that are attached to ferritins.
TitleInvestigating the molecular, cellular and circuit effects of transcranial magnetic stimulation
Investigator
Arnaud Y Falchier, Alexander Opitz, Andreas Vlachos
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method which can alter brain
activity in humans in a safe manner.
TitleInvestigating the response of CNS neurons to electric and magnetic stimulation
Investigator
Shelley Fried
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Our long-term goals are to better understand the response of neurons to artificial stimulation, and, to use this
knowledge to develop new and more effective strategies for stimulating non- or improperly-functioning neurons
of the CNS.
TitleLeveraging ethical dissension among capacity, beneficence and justice in clinical trials of neurotherapeutics in the severely disabled: lessons from schizophrenia
Investigator
Rachel A Davis, Judith Morse Gault, Elyn R. Saks
Institute
university of colorado denver
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Ethical concerns raised from both current and historically controversial psychosurgeries are driving disparities in
accessibility to emerging BRAIN Initiative technology for those with severe, disabling, chronic mental illness like
individuals with treatment-refractory schiz
TitleMapping cerebellar granule cell function with novel genetic and optical tools
Investigator
Gerard Joey Broussard
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Recent evidence from multiple laboratories in both human and animal models supports a role for the granule cell (GrC)
pathway of the cerebellum in representing a wide range of sensory, motor, and internal information.
TitleMapping the neuronal circuitry underlying indirect striatal to hypothalamicconnectivity and its role in feeding
Investigator
Miriam E Bocarsly
Institute
national institute on alcohol abuse and alcoholism
Fiscal Year
Funding Opportunities Number
Project Number
Food consumption is fundamental to species survival and understanding the neuronal circuitry underlying feeding behaviors is of the utmost importance.
TitleMechanism underlying Nerve Conduction Block by High Frequency (kHz) Biphasic Stimulation
Investigator
Changfeng Tai
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Based on the gate-control theory of pain, traditional spinal cord stimulation (SCS) to treat chronic back/leg pain
utilizes 40-60 Hz stimulation that activates spinal dorsal columns to elicit paresthesia over a patient’s painful
region.
TitleMechanisms of Active Sensing in Drosophila
Investigator
Marie Suver
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to study the cellular basis of active sensation. A crucial function of all nervous systems is to distinguish between sensory stimuli originating from the external world and that generated by our own movements.
TitleMechanisms of Information Routing in Primate Fronto-striatal Circuits
Investigator
Thilo Womelsdorf
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
This project focuses on developing new analysis tools to investigate the mechanisms of information
routing in primate fronto-striatal circuits during goal-directed behavior.