PROJECT SUMMARY. New advances in calcium imaging make it possible to survey the brains of behaving animals at
single-neuron resolution, thereby promising to transform the field of neuroscience. However, existing statistical models
and methods are inadequate for this complex and noisy data.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleModels and Methods for Calcium Imaging Data with Application to the Allen Brain Observatory
Investigator
Michael Buice, Daniela Witten
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
TitleNeural circuit mechanisms underlying hierarchical visual processing in Drosophila
Investigator
Maxwell Holte Turner
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project summary
Understanding how neural circuits give rise to sensory computation and, ultimately, perception, requires
connecting biological features of neural circuits to abstract models of neural computation.
TitleNeuroethics of Predictive MRI Testing: Parental Attitudes Towards Pre-Symptomatic Identification of Autism Spectrum Disorder
Investigator
Kate E. Macduffie
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Machine-learning-based classification of neuroimaging data (hereafter ML-MRI) to predict clinical
diagnoses has increased substantially in the last decade.
TitleNeuronal and Dopaminergic Contributions to Dissimilar Evoked Hemodynamic Responses in the Striatum
Investigator
Lindsay Walton
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI) is a non-invasive
imaging technique that infers the presence of increased brain activity from localized increases in oxygenated
hemoglobin.
TitleNeuronal population dynamics within and across cortical areas
Investigator
Brent D. Doiron, Matthew A Smith, Byron M. Yu
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: The cortex must both track and process dynamically changing environments as well
as store and combine diverse inputs to generate complex behavior. Further, the neuronal circuits that
accomplish this must be malleable to changing contexts, such as during attention related tasks.
TitleNonlinear Causal Analysis of Neural Signals
Investigator
Terrence J Sejnowski
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The goal of this research is to develop new multivariate data analysis techniques for neural recordings that
reveal causal dependencies between recording sites.
TitleNWB:N: A Data Standard and Software Ecosystem for Neurophysiology
Investigator
Lydia Lup-Ming Ng, Oliver Ruebel
Institute
university of calif-lawrenc berkeley lab
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Brain function is produced by the coordinated activity of multiple neuronal types that are widely distributed
across many brain regions.
TitleOpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data
Investigator
Russell A Poldrack
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The NIH BRAIN Initiative is supporting a broad portfolio of neuroscience research aimed at
revolutionizing our understanding of the brain.
TitleOptical measurement of causal functional connectivity in posterior parietal cortex
Investigator
Daniel E Wilson
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The mouse posterior parietal cortex (PPC) has emerged as an essential region for decision-making during
memory-guided decision-making tasks.
TitleOptimizing noninvasive modulation of prediction and episodic memory networks via cerebellar stimulation
Investigator
Shruti Dave
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY ABSTRACT
The lateral cerebellum (Crus I/II) interacts with two dissociable large-scale brain networks — the executive
control (ECN) and default mode networks (DMN), which support distinct cognitive functions (e.g., prediction
versus episodic memory, respectively).
TitleQuantifying the role of adaptation in olfactory coding through the logic of navigation
Investigator
Nirag Kadakia
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This project’s long-term goal is a fuller understanding of the neurobiological mechanisms of olfactory sensory
adaptation that facilitate odor discrimination in the natural world.
TitleRAVE: A New Open Software Tool for Analysis and Visualization of Electrocorticography Data
Investigator
Michael S Beauchamp
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
A fast-growing technique in human neuroscience is electrocorticography (ECOG), the only technique
that allows the activity of small population of neurons in the human brain to be directly recorded.
TitleReal-time statistical algorithms for controlling neural dynamics and behavior
Investigator
Il Memming Park, Jonathan William Pillow
Institute
state university new york stony brook
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
High-throughput experimental neuroscience has made it possible to observe behavior of many
animals, as well as a large groups of neurons simultaneously, providing an exciting opportunity for
figuring out how the neural system performs computations that underlie perception,
TitleRecombinant Immunolabels for Nanoprecise Brain Mapping Across Scales
Investigator
James S Trimmer
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
Recombinant Immunolabels for Nanoprecise Brain Mapping Across Scales
Understanding brain function and dysfunction requires an understanding of the circuitry of the brain from
molecules to cells to circuits.
TitleRepetitive transcranial ultrasound stimulation for modulating brain rhythms
Investigator
Jacek Dmochowski
Institute
city college of new york
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The goal of the proposed research career development program is to allow the applicant to acquire training in
a new form of brain stimulation using ultrasonic waves.
TitleResource for Multiphoton Characterization of Genetically-Encoded Probes
Investigator
Mikhail Drobizhev
Institute
montana state university - bozeman
Fiscal Year
Funding Opportunities Number
Project Number
Two-photon laser scanning microscopy powers many projects in the.
TitleSpatially Resolved Methylomes to Map Neuronal Cell-Type Connectivity in Tissue
Investigator
Robert Youssefian Henley
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The BRAIN initiative has put forth the development of a neuronal cell-type census as the first step towards
mapping the structure and components of neuronal circuits.
TitleTaking DISCO Live: Dual pathway Imaging of Striatal Circuit Output in vivo
Investigator
Nicole Calakos
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The basal ganglia are critical for the learning and subsequent selection of motor programs. In health,
adaptive plasticity in the basal ganglia enables easy execution of complex motor tasks through
formation of habits.
TitleThe biophysics and potential cell-type selectivity of acoustic neuromodulation
Investigator
Robert Crooks Froemke, Eitan Kimmel, Shy Shoham
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Neuroscience has an essential requirement for large-scale perturbation tools. Such
tools would be transformative in the mapping of brain function, the causal testing of
neurotheoretic models, and the diagnosis and treatment of neurological disorders.
TitleThe Brainstorm Project: A Collaborative Approach to Facilitating the Neuroethics of Bioengineered Brain Modeling Research
Investigator
Insoo Hyun
Institute
case western reserve university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary – Abstract
Neuroscientists are getting close to building realistic bioengineered ex vivo human brain models
by: (1) introducing perfusable vascular networks to maintain tissue viability and promote 3D
brain model growth; (2) generating the full complement of currently missing cell ty