Changes in the strength of GABAergic transmission is heavily influenced by posttranslational modifications and allosteric modulators like benzodiazepines and neurosteroids.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
O-GlcNac Modulation of GABAergic Transmission
Investigator
Shekinah Phillips
Institute
university of alabama at birmingham
Fiscal Year
Funding Opportunities Number
Project Number
Title
OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data
Investigator
Russell A Poldrack
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract The BRAIN Initiative is supporting a broad portfolio of neuroscience research aimed at revolutionizing our understanding of the brain.
Title
Optimizing ultraflexible electrodes and integrated electronics for high-resolution, large-scale intraspinal recording and modulation
Investigator
Lan Luan, Chong Xie
Institute
rice university
Fiscal Year
Funding Opportunities Number
Project Number
Electrophysiology is a critical technology in neuroscience as a direct measure of neuronal functions. It has become routine for scientists to record and stimulate neuron populations in different brain regions in awake behaving animals, correlating activity with behavior.
Title
Oxytocin Modulation of Neural Circuit Function and Behavior
Investigator
Richard W Tsien
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Oxytocin is a peptide hormone synthesized and released from the hypothalamus for reproduction, maternal care, and social behavior, as well as various ‘non-social’ aspects of internal state and physiological processes.
Title
Post-trial Access, Clinical Care, Psychosocial Support, and Scientific Progress in Experimental Deep Brain Stimulation Research
Investigator
Joseph J. Fins, Gabriel Lazaro-Munoz
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Public and private research funders have heavily invested in the application of implantable neurotechnologies to improve the management of treatment-resistant conditions and loss of function (e.g., deep brain stimulation (DBS) systems for recovery after traumatic brain injury (TBI
Title
Postnatal experience shapes gene expression and connectivity development in the cortex
Investigator
Alexander Nevue
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Postnatal sensory experience has a profound effect on the maturation, composition, and connectivity of cortical cell types, but systematic analyses of these changes have not yet been feasible.
Title
Probing form and function of memory representations in the hippocampus of memory expert birds
Investigator
Emily Lambert Mackevicius
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract Mental disorders that affect the hippocampus disrupt people’s ability to form one-shot memories. My goal is to lead an independent lab, linking biological properties of hippocampal neurons to the ability to perform memory- guided cognitive behaviors.
Title
Processing of visual information by spatial memory circuits in the avian brain
Investigator
Hannah L Payne
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT. Research Project: Spatial memory – memory of where an event happened or an object was located – depends on the hippocampus in a wide range of vertebrate species, including mammals and birds. In humans, most spatial memories are formed through visual experience.
Title
Psych-DS: A FAIR data standard for behavioral datasets
Investigator
Melissa Kline
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Summary: Behavioral data is central to biomedical research, including both synchronous measures (e.g. brain activation and button-presses from a reading task in an fMRI scan), and those performed independently (e.g.
Title
Role of cortical connections to higher-order thalamic nuclei in visual decision-making
Investigator
Ariana R Andrei
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY To guide decisions, visual information must flow from primary visual cortex (V1) to prefrontal cortex (PFC), via multiple, parallel cortico-cortical and cortico-thalamo-cortical connections.
Title
Role of multi-regional neuronal reactivations in reward-based memories
Investigator
Celine Drieu
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The goal of this project is to provide the building blocks for an independent research program focused on the neural basis of reward-based memory across distributed brain networks.
Title
Scientific and Public Outreach of Cell Type Taxonomies (SPOCTT) Initiative
Investigator
Kaitlyn Casimo, Jeremy A Miller
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Single cell transcriptomics has transformed the field of brain cell type classification, allowing simultaneous measurement of enough molecular features from enough cells to categorize neurons quantitively and with high conservation across brain areas and species.
Title
Sex, Physiological State, and Genetic Background Dependent Molecular Characterization of CircuitsGoverning Parental Behavior
Investigator
Brandon Logeman
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Parental care is essential for offspring well-being and survival yet requires a significant invest from adults without immediate benefit, suggesting the existence of hard-wired mechanisms governing its control.
Title
Systematic characterization of spinal cord stimulation effects on dorsal horn populations
Investigator
Andrei D Sdrulla
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
There is a substantial need to understand the fundamental biological mechanisms of neuromodulation therapies in order to improve clinical delivery and outcomes (RFA-NS-20-006).
Title
The development of multimodal dynamics in a short-term memory system
Investigator
Gregory Patrick Davis
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT Persistent activity in neural circuits supports a variety of brain functions from motor control to navigation to perceptual decision-making.
Title
The Impact of Vitamin D on mTOR Signaling, Seizures, and Motor Behavior in a Mouse Model of Hyperactive mTOR Induced Epilepsy and Ataxia
Investigator
David Narvaiz
Institute
baylor university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract Increased mammalian target of rapamycin (mTOR) signaling is a known cause of treatment resistant epilepsy.
Title
The Neuroimaging Brain Chart Software Suite
Investigator
Christos Davatzikos, Yong Fan, Ilya M Nasrallah, Haochang Shou
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
This study proposes to refine, integrate and disseminate the NeuroImaging Brain Chart (NIBCh) software toolbox and machine learning (ML) model library, an ecosystem of software components enabling constructive integration, statistical harmonization, and ML-centric data analyses across studies.
Title
Time-varying spatiotemporal causal interactions in the functional brain networks
Investigator
Nan Xu
Institute
georgia institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
This proposal describes a five-year career development program to prepare the candidate, Dr.
Title
Towards an integrated analytics solution to creating a spatially-resolved single-cell multi-omics brain atlas
Investigator
Panagiotis Roussos, Guo-Cheng Yuan
Institute
icahn school of medicine at mount sinai
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The maintenance and function of the nervous system depends on cell-cell interactions among neuronal and non-neuronal cell populations, which occur through physically binding cell membrane surface or secreted proteins, triggering signaling cascades that activate cell-type gene regu
Title
Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform
Investigator
Patrick Goodwill
Institute
magnetic insight, inc.
Fiscal Year
Funding Opportunities Number
Project Number
In this SBIR grant proposal, “Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform,” we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogen