Funded Awards

Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment Patterned sensory stimulation (PSS) is a non-invasive technique for manipulating brain activity and states, typically employing periodic light flicker or auditory tones presented at regular intervals.

Unveiling mechanisms of neural stimulation technologies is an important goal of the Brain Initiative (RFA-NS-20-006).

Abstract: Our goal is to develop a cellular level understanding of how transcranial magnetic stimulation (TMS) may activate neurons in the human cerebellum (Cb) using (i) electrophysiological measurements in an in vitro turtle Cb, (ii) computational modeling of the induced electric (E) fields in the

Non-invasive neuromodulation approaches have been developed to enable the modulation of neural tissue without necessitating invasive surgical procedures.

Neurostimulation, including invasive methods like deep brain stimulation (DBS), is an increasingly important approach to treating mental illness. It offers the possibility of directly targeting the circuit dysfunctions that produce mental disorders.

PROJECT ABSTRACT Large-scale realistic model of neuronal network is a powerful tool for studying neural dynamics and cognitive functions. It integrates multi-scale neurobiological mechanisms/processes identified through diverse hypotheses and experimental data into a single platform.

Recently, several lines of evidence have supported that synaptic dysfunction represents one of the earliest brain changes in Alzheimer’s disease (AD), leading to hyper-excitation in neuronal circuits.

Project Summary Electrical stimulation of deep brain structures is an essential tool for the causal investigation of neural systems that regulate learning and decision making.

PROJECT SUMMARY To flexibly execute behavior, choices are made based on previous outcomes that will maximize reward. Crucially, learning the value of each action to obtain a reward is thought to drive this decision making process. In a value-based decision making framework, these values are first co

ABSTRACT The common marmoset provides a very relevant primate model for understanding the organization of the human nervous system and the diseases that affect it.

Serotonergic neuromodulation is a crucial factor in regulating several aspects of brain function, from mood disorders to appetite, reward and motivation, and in maintaining balance of sensory perception. However, the network mechanisms by which it modulates brain dynamics are elusive.

Today, the most widespread tool for measuring whole-brain activity noninvasively is functional magnetic resonance imaging (fMRI).

Humans make rich inferences about the relationships between entities in the world from scarce information. For example, we can find a novel destination after seeing a few street numbers, or find a page in a dictionary by glancing at a few words in other pages.

Numerous neuroscience and clinical applications exist for a noninvasive neuromodulation technology that can reach deep in the brain with high resolution. One compelling clinical application is the treatment of drug addiction, a major public health challenge in the US.

The basal ganglia are a collection of subcortical nuclei studied for their contributions to movement, action selection, habit formation, and reward learning as well as their dysfunction in movement disorders.

Understanding the brain processes underlying alcohol use and misuse are essential for the development of effective treatments for alcohol use disorder or AUD. Human brain imaging has greatly contributed to our current understanding of AUD, but much more remains to be understood.

CRCNS Research Proposal: Collaborative Research: Multimodal Dynamic Causal Learning for Neuroimaging A Project Description A.1 Introduction Many analyses of fMRI and other neuroimaging data aim to discover the underlying causal or commu- nication structures that generated that activity.1,2 An acc

The ability to predict when external events will occur, such as anticipating the actions of a predator or the availability of food, is critical for survival.

Detailed description of the proposed use of the animals, including species, strains, ages, sex, and number to be used; Dissociated, primary cultures will be prepared from the cortex of new born mice of either sex (mus musculus, Postnatal day 0-1).