Funded Awards

PROJECT SUMMARY Neurons in the visual cortex form an intricate connectivity structure and topographic arrangement. The structural and morphological organization of the neurons is known to constrain its functional properties.

Project Summary Primate species frequently use social information to inform their decisions, for instance, to help make inferences about potential threats or rewards in the environment.

Understanding the brain is a profound and fascinating challenge, captivating the scientific community and the public alike. The lack of effective treatment for most brain disorders makes training the next generation of neuroscientists, engineers and physicians a key concern.

Project Summary/Abstract Circuits in the brain control motor output to generate the precise behaviors required for survival. Dysfunction of these circuits results in devastating movement disorders such as Parkinson’s disease and amyotrophic lateral sclerosis.

Project Summary A key goal in neuroscience is determining how microcircuit structure predicts circuit function. An intriguing idea, supported by some theoretical models, is that variation in microcircuit composition supports functional specialization.

PROJECT SUMMARY Charcot-Marie-Tooth (CMT) disease is a genetically and clinically heterogeneous group of inherited peripheral neuropathies that is characterized by damage to long motor and sensory axons.

ABSTRACT Substance use disorder is a chronic relapsing disease that is characterized by repeated drug use despite negative consequences.

High-speed volumetric imaging of dynamic neuronal activity over long periods is a challenging but essential goal in neuroscience. Conventional optical measurements of neuronal activity mostly rely on calcium signals.

PROJECT SUMMARY/ABSTRACT Higher brain functions include the ability to learn expectations about the world, update those expectations appropriately when given new sensory information, and use those continually updating expectations to guide behavior.

Project Summary The ability to remember information, whether after short or long delays, is a fundamental human ability.

Project Summary Understanding cell-type-specific gene functions, expression dynamics, and regulatory mechanisms in complex brains is still challenging.

Project Summary The human brain contains an astonishing diversity of neuronal and glial cell types distributed across dozens of functional areas.

Project Summary Cortical interneurons (cINs) are inhibitory cells that are born in surplus far from the cortex. During prenatal timepoints, cIN precursors migrate into the mouse visual cortex (V1) where only a fraction are selected to survive.

PROJECT SUMMARY/ABSTRACT Many animals rely on spatial cognition for daily survival in order to recognize familiar places and process movements through or between locations. A variety of space-encoding cells in the hippocampus are important for spatial behaviors in mammals.

PROJECT SUMMARY Achieving a detailed understanding of the neural codes of sensation, action, and cognition requires technologies that can causally perturb each of the major dimensions of population coding one at a time with extremely high precision across multiple brain areas.

This project aims to develop the 2P-ActivityScope™, a revolutionary new microscope based on a technological breakthrough called second-generation Scanned Line Angular Projection (SLAP2) two photon laser scanning microscopy that was recently developed by Dr.

PROJECT SUMMARY/ABSTRACT Miniaturized silicon neurochemical probe to monitor brain chemistry.

ABSTRACT Much evidence suggests that the development of orientation selectivity and maps in primary visual cortex (V1) is instructed by spontaneous patterns of input activity, without the necessity of visual experience.

The cerebellum has been overlooked for its potential for neuromodulation for decades.

Project summary Nausea is an unpleasant sensation of visceral malaise often accompanied by an involuntary urge to vomit. Nausea responses to toxin ingestion and infection are evolutionarily beneficial survival behaviors that avoid or expel toxins which may cause peripheral tissue damage.