HNN U24 DISSEMINATION PROJECT SUMMARY The Human Neocortical Neurosolver (HNN) neural modeling tool was developed with BRAIN Initiative funding (R01EB022889: 09/2016–06/2020) to meet the Initiative’s goal to “develop innovative technologies to understand brain circuits and ensembles of circuits th
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Dissemination of the Human Neocortical Neurosolver (HNN) software for circuit level interpretation of human MEG/EEG
Investigator
Stephanie Ruggiano Jones
Institute
brown university
Fiscal Year
Funding Opportunities Number
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Title
Distinct contributions of converging neural pathways to auditory learning
Investigator
Santiago Jaramillo, James Murray
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
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PROJECT SUMMARY/ABSTRACT Effective interpretation of sensory stimuli relies on the ability to discriminate stimulus features and link them to appropriate behavioral responses depending on past experience.
Title
Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony
Investigator
Zoe Rebecca Donaldson, Yevgenia Kozorovitskiy, John Rogers
Institute
northwestern university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The vertebrate brain has evolved to enable complex social interactions, essential for survival. Brains of animals engaged in a shared social interaction exhibit inter-brain synchronization of neural activity, detectable at several levels of analysis.
Title
Electrophysiology-Compatible Wearable Transcranial Focused Ultrasound Neuromodulation Array Probes
Investigator
Bin He
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Noninvasive high precision neuromodulation technologies are crucial for probing mechanisms of neural circuits and enabling the non-pharmacological treatment of brain disorders.
Title
ENABLING SUBMILLISECOND-TIMESCALE TWO-PHOTON RECORDING OF VOLTAGE DYNAMICS IN THREE DIMENSIONS IN VIVO
Investigator
Laurent Bourdieu, Francois St-Pierre
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Because neurons integrate and process information via modulation of their membrane potential, the ability to monitor voltage is critical to understanding how single and groups of neurons compute.
Title
Extending ezBIDS, NiiVue and dcm2niix for user-friendly cloud-based integration and visualization
Investigator
Christopher Rorden
Institute
university of south carolina at columbia
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract Cloud-based analyses and easily shared data formats are revolutionizing neuroimaging. We will develop software to fill gaps created by these two trends. We will develop and refine software to visualize and analyze the data from the BRAIN Initiative.
Title
Functions of locus coeruleus norepinephrine neurons in decision making across multiple timescales
Investigator
Jeremiah Yaacov Cohen, Daniel Hans O'connor
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY Norepinephrine (NE) is a neurotransmitter released by a small number of neurons in the locus coeruleus (LC), with extensive innervation of the neocortex. Prior work in humans and other mammals led to the hypothesis that LC-NE neurons modulate multiple forms of decision making.
Title
Functions of the Cortical Amygdala in social behavior
Investigator
Antonio V Aubry
Institute
icahn school of medicine at mount sinai
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In most cases, aggression is a necessary, adaptive component of social behavior.
Title
Gulf Coast Consortia (GCC) Research Evaluation and Commercialization Hub
Investigator
Peter J Davies, Suzanne Marie Tomlinson, Stanley J Watowich
Institute
texas a&m university health science center
Fiscal Year
Funding Opportunities Number
Project Number
In recent years, the NIH has awarded over $850M annually to the numerous research institutions and hospitals within the Texas Medical Center (TMC; Houston, TX), producing ever-increasing numbers of biomedical discov- eries.
Title
High-throughput 3D mapping of large mammalian brains via integration of precision tissue sectioning and light sheet imaging
Investigator
Ji Wang, Nicholas Bruce Evans, Hsuan Lee, Jeffrey Stirman
Institute
lifecanvas technologies, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Whole-brain mapping at the cellular and subcellular levels is crucial to systematically understand brain functions and disorders.
Title
High-throughput engineering of ligand-selective fluorescent biosensors for detecting endogenous and exogenous opioids
Investigator
Andre Berndt, Michael R Bruchas
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT Neuropeptide modulation of neuronal circuits is strongly linked to many crucial behaviors such as exploration, stress, memory formation, learning, and many pathophysiological conditions.
Title
High-throughput measurement of neuronal projections and synapses using Synapse-seq
Investigator
Evan Z Macosko
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY The brain is composed of thousands of highly specialized cell types that form very specific synaptic connections with each other. Together, these connections form neural circuits that are the structural basis of brain function.
Title
Highly multiplexed circuit mapping using barcoded rabies viruses and in situ sequencing.
Investigator
Ian R Wickersham, Shenqin Yao
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT Understanding the function of neural circuits requires thorough investigation of two circuit elements: cell types and connectivity.
Title
Hybrid TMS/MRI system for regionally tailored causal mapping of human cortical circuits and connectivity
Investigator
Berkin Bilgic, Susie Yi Huang, Aapo Nummenmaa, Jason P Stockmann
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary. We propose a new coil array that will enable next-generation causal brain mapping with unprecedented flexibility, resolution and precision.
Title
Identifying human-specific neural progenitors and their role in neurodevelopment
Investigator
Sumin Jang
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Humans have highly advanced cognitive abilities and motor skills, characteristics which are reflected in the enlarged size and cell diversity of our central nervous system (CNS).
Title
Identifying the neural mechanisms of goal-directed decision-making in Parkinson's disease using closed-loop deep brain stimulation
Investigator
Colin Hoy
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
TITLE: IDENTIFYING THE NEURAL MECHANISMS OF GOAL-DIRECTED DECISION-MAKING IN PARKINSON’S DISEASE USING CLOSED-LOOP DEEP BRAIN STIMULATION PROJECT SUMMARY People with Parkinson’s disease commonly suffer from non-motor symptoms, including motivation deficits, that impact quality of life more than c
Title
Implantable 3D fluorescence imaging with high-speed, addressable laser scanning in moving mice
Investigator
Kenn R Oldham
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary The goal of this work is to achieve high-speed optical fluorescence imaging of 3D brain volume in moving, behaving mice, using miniature scanning mirrors in an implantable, fiber-coupled microscope.
Title
Implications of Prefrontal Cortex Development for Adolescent Reward Seeking Behavior
Investigator
Gabriela Manzano Nieves
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY As we get older, we learn to modulate our behaviors to optimize reward outcomes. These adaptive choices are orchestrated by current sensory conditions, internal cognitive states, and future expectations.
Title
Improving Recruitment, Engagement, and Access for Community Health Equity for BRAIN Next-Generation Human Neuroimaging Research and Beyond (REACH for BRAIN)
Investigator
Susie Yi Huang, Jonathan David Jackson, Francis X Shen
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract Although BRAIN 2.0 called for the BRAIN Initiative to “prioritize diversity and inclusion as a fundamental pillar,” research with the human neuroimaging technologies being developed by BRAIN Initiative continues to rely on non-representative convenience samples.
Title
Improving the Speed of Galvo-Scanners
Investigator
Chris Xu
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract Optical methods provide high-resolution, non-invasive measurement of neural function, ranging from single neurons to entire populations, in the intact brain. Nevertheless, limited penetration depth, spatial scale and temporal resolution remain the main challenges for optical imaging.