PROJECT SUMMARY Postnatal sensory experience has a profound effect on the maturation, composition, and connectivity of cortical cell types, but systematic analyses of these changes have not yet been feasible.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
Postnatal experience shapes gene expression and connectivity development in the cortex
Investigator
Alexander Nevue
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
Title
Pre-motor neural circuits enable versatile and sequential limb movements
Investigator
Julie H Simpson
Institute
university of california santa barbara
Fiscal Year
Funding Opportunities Number
Project Number
Abstract Movements are measurable outputs of the nervous system and simple movements can be combined to compose complicated behaviors. We use limb tracking and connectome analyses to map the neural circuits controlling the elemental leg movements in Drosophila grooming.
Title
Probing form and function of memory representations in the hippocampus of memory expert birds
Investigator
Emily Lambert Mackevicius
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract Mental disorders that affect the hippocampus disrupt people’s ability to form one-shot memories. My goal is to lead an independent lab, linking biological properties of hippocampal neurons to the ability to perform memory- guided cognitive behaviors.
Title
Processing of visual information by spatial memory circuits in the avian brain
Investigator
Hannah L Payne
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT. Research Project: Spatial memory – memory of where an event happened or an object was located – depends on the hippocampus in a wide range of vertebrate species, including mammals and birds. In humans, most spatial memories are formed through visual experience.
Title
Psych-DS: A FAIR data standard for behavioral datasets
Investigator
Melissa Kline
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Summary: Behavioral data is central to biomedical research, including both synchronous measures (e.g. brain activation and button-presses from a reading task in an fMRI scan), and those performed independently (e.g.
Title
Reconfigurable 3D Origami Probes for Multi-modal Neural Interface
Investigator
Gyorgy Buzsaki, Michael Patrick Flynn, Euisik Yoon
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Over the decades, various neurotechnologies have made significant advancements to meet the highest priority goals enumerated in the BRAIN 2025 Report.
Title
Responsive Neurostimulation for Treatment Resistant Depression
Investigator
Andrew D Krystal
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY This UH3 application seeks to address the major public health burden of treatment-resistant major depression (trMDD) by developing a novel form of Deep Brain Stimulation (DBS).
Title
Role of coordinated multi-area reactivations during transitions between automatic and flexible behaviors.
Investigator
Maksim V Bazhenov, Joshua D Berke, Karunesh Ganguly
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Abstract Sleep occupies a large part of our lives and is widely believed to perform essential functions. During sleep, the neuronal rules of engagement and population dynamics are clearly different than waking.
Title
Role of cortical connections to higher-order thalamic nuclei in visual decision-making
Investigator
Ariana R Andrei
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY To guide decisions, visual information must flow from primary visual cortex (V1) to prefrontal cortex (PFC), via multiple, parallel cortico-cortical and cortico-thalamo-cortical connections.
Title
Role of multi-regional neuronal reactivations in reward-based memories
Investigator
Celine Drieu
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The goal of this project is to provide the building blocks for an independent research program focused on the neural basis of reward-based memory across distributed brain networks.
Title
Scaling Volumetric Imaging, Analysis and Science Communication Using Immersive Virtual Reality
Investigator
Gianfranco Doretto, Michael David Morehead, George A Spirou
Institute
istovisr
Fiscal Year
Funding Opportunities Number
Project Number
Over the past 15 years, new microscope technologies and methods for high throughput imaging have revolutionized structural biology by extending the resolution and scale of datasets in 3 dimensions.
Title
Scientific and Public Outreach of Cell Type Taxonomies (SPOCTT) Initiative
Investigator
Kaitlyn Casimo, Jeremy A Miller
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary Single cell transcriptomics has transformed the field of brain cell type classification, allowing simultaneous measurement of enough molecular features from enough cells to categorize neurons quantitively and with high conservation across brain areas and species.
Title
Sensing and manipulating neuromodulatory signaling in vivo
Investigator
Haining Zhong
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Neuromodulation, such as that mediated by the neuromodulators norepinephrine, acetylcholine, and dopamine, imposes powerful control over brain function. It regulates the excitability, synaptic plasticity, and other aspects of neuronal function.
Title
SensiTrak: Automated Assessment of Forelimb Sensation
Investigator
Camilo Andres Sanchez
Institute
vulintus, llc
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract Current common methods for measuring somatosensory function in preclinical rodent models generally rely on withdrawal responses to uncomfortable or painful stimuli.
Title
Sex, Physiological State, and Genetic Background Dependent Molecular Characterization of CircuitsGoverning Parental Behavior
Investigator
Brandon Logeman
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Parental care is essential for offspring well-being and survival yet requires a significant invest from adults without immediate benefit, suggesting the existence of hard-wired mechanisms governing its control.
Title
State-dependent modulation of taste and temperature integration in Drosophila
Investigator
Fumika Hamada
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY: Animals constantly detect different environmental stimuli and change their behavior or physiology based on their internal state. How animals integrate the external multiple sensory information with the internal state is largely unclear.
Title
Systematic characterization of spinal cord stimulation effects on dorsal horn populations
Investigator
Andrei D Sdrulla
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
There is a substantial need to understand the fundamental biological mechanisms of neuromodulation therapies in order to improve clinical delivery and outcomes (RFA-NS-20-006).
Title
Thalamic Coordinated Reset Deep Brain Stimulation for Upper Extremity Essential Tremor: Proof of Principle Study
Investigator
Jerrold L Vitek, Jing Wang
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Essential tremor (ET) is a common neurologic disorder affecting over 10 million people in the United States. Pathologic synchrony in the cerebello-thalamo-cortical (CTC) network has been considered to underlie the development of ET.
Title
The development of multimodal dynamics in a short-term memory system
Investigator
Gregory Patrick Davis
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT Persistent activity in neural circuits supports a variety of brain functions from motor control to navigation to perceptual decision-making.
Title
The Impact of Vitamin D on mTOR Signaling, Seizures, and Motor Behavior in a Mouse Model of Hyperactive mTOR Induced Epilepsy and Ataxia
Investigator
David Narvaiz
Institute
baylor university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract Increased mammalian target of rapamycin (mTOR) signaling is a known cause of treatment resistant epilepsy.