DESCRIPTION (provided by applicant): Electrophysiology and fluorescent imaging are widely used to study neural activity in vivo.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
Title
LOCATER: Large-scale Observation of Cellular Activity Through Exosomal Reporters
Investigator
Feng Zhang
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Title
Massive scale electrical neural recordings in vivo using commercial ROIC chips
Investigator
Konrad P. Kording, Andreas Schaefer
Institute
rehabilitation institute of chicago d/b/a shirley ryan abilitylab
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Current scaling behavior in electrical recording is dominated by the difficulty of fabricating systems with many high bandwidth channels.
Title
Multiplexed Multiphoton Interrogation of Brain Connectomics
Investigator
Xue Han, Siddharth Ramachandran
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Multiphoton laser scanning microscopy has revolutionized neuroscience since it is less invasive than traditional electrophysiology methods for probing neuronal processes.
Title
MULTISCALE ANALYSIS OF SENSORY-MOTOR CORTICAL GATING IN BEHAVING MICE
Investigator
Dieter Jaeger, Garrett B. Stanley
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): To address the core question underlying the Obama Brain Initiative to better understand the function of complex brain circuits, we propose a multi-scale recording and data analysis project to study the dynamical interactions between sensory cortex, motor cor
Title
Multiscale Imaging of Spontaneous Activity in Cortex: Mechanisms, Development and Function
Investigator
R Todd Constable, Michael C. Crair
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The purpose of this RFA is to promote the integration of experimental, analytic and theoretical capabilities for the examination of neural circuits and systems.
Title
Network basis of action selection
Investigator
Anatol Kreitzer, Takaki Komiyama, Byungkook Lim
Institute
j. david gladstone institutes
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The anatomical substrates and cellular mechanisms underlying reward-dependent learning have been studied for decades, but the specific circuit and network interactions between the cortex, striatum, and midbrain that mediate action selection have not been sys
Title
Neural ensembles underlying natural tracking behavior
Investigator
Ila R. Fiete, Alexander C Huk, Nicholas J Priebe
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The system that controls smooth pursuit eye movements is one of the most accessible, promising systems for understanding how neural circuits transform sensory inputs into actions.
Title
Neural Monitoring with Magnetically-Focused Electrical Impedance Tomography (mf-EIT)
Investigator
Daniel Kenneth Freeman
Institute
charles stark draper laboratory
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): There is a great need in clinical neuroscience for improved methods of non-invasively monitoring brain activity.
Title
Neuron selective modulation of brain circuitry in non-human primates
Investigator
Charles F Caskey, Li Min Chen, William A Grissom
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): All presently available neural stimulation methods are either invasive or can only be moderately localized, and a neurostimulation method that could overcome these limitations would be invaluable for brain circuit investigation.
Title
Neuronal voltage tracers for photoacoustic imaging in the deep brain
Investigator
Jon Thomas Sack
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The overarching goal of this project is to develop molecular tracers for imaging neuronal voltage changes deep in the brain.
Title
Neurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy
Investigator
Gregory A Worrell
Institute
mayo clinic rochester
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Approximately 1/3 of people living with epilepsy (PWE) continue to have seizures despite anti-epileptic drugs (AEDs). Recent trials using therapeutic brain stimulation show reductions in seizures, but rarely provide seizure free outcomes.
Title
Non-degenerate multiphoton microscopy for deep brain imaging
Investigator
Anna Devor, Yeshaiahu L Fainman
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The overarching goal of this proposal is to push the depth penetration of multiphoton microscopy targeting neuroscience applications in need of large-scale recording of cortical activity where high resolution requirement (in the order of singl microns) cann
Title
Northern Lights collaboration for better 2-photon probes
Investigator
Robert E. Campbell, Nathan G Clack, Mikhail Drobizhev, Thomas E Hughes
Institute
montana state university - bozeman
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The Northern Lights collaboration for better 2-photon probes will combine the expertise of four very different investigators and laboratories from Montana and Canada with complementary interests and skills to tackle a fundamental problem in imaging of the a
Title
Novel optrodes for large-scale electrophysiology and site-specific stimulation
Investigator
John Assad, Luca Berdondini, Massimo Devittorio, Bernardo L Sabatini
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brains of mammals contain an extraordinarily large number of neurons whose activity and interconnections determine the function of circuits that monitor our sensory environment, dictate our motor choices, form memories, and guide all behavior.
Title
Novel tools for cell-specific imaging of functional connectivity and circuit operations
Investigator
Ehud Isacoff
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Fundamental to understanding brain function is the ability to relate the spatio-temporal firing patterns of specific neurons to their functional connectivity and determine the strength and experience-dependent regulation of those connections.
Title
Optical tools for extended neural silencing
Investigator
Matthew J Kennedy, Chandra L Tucker
Institute
university of colorado denver
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION: Conditionally silencing the activity of specific neural ensembles is a powerful approach for mapping the circuits responsible for specific behaviors.
Title
Optical Tools to Study Neuropeptide Signaling
Investigator
Mathew Tantama
Institute
purdue university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neuropeptides are neuromodulators that regulate the physiology of cells, synapses, and neural circuits in the brain.
Title
Potentiometric photoacoustic imaging of brain activity enabled by near infrared to visible light converting nanoparticles
Investigator
Paras N. Prasad, Jun Xia
Institute
state university of new york at buffalo
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This application is in response to the President's Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative.
Title
SCAPE microscopy for high-speed in-vivo volumetric microscopy in behaving organisms
Investigator
Elizabeth M. C. Hillman
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Despite the growing availability of optical markers of neuronal activity, as well as genetic tools for optical manipulation, current optical microscopy techniques for imaging the intact brain at cellular resolution have approached their limits, particularly
Title
Self-Motile Electrodes for Three Dimensional, Non-perturbative Recording and Stimulation
Investigator
Nicholas A Melosh
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Transitioning from small numbers of neural depth recording electrodes to many thousands requires consideration not only of data management, but also how to non-destructively deliver these electrodes into the desired brain regions.