Project Abstract
Background/Description.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleResponsive Neurostimulation for Loss of Control Eating
Investigator
Casey Harrison Halpern, James D Lock, Robert C Malenka, Tara L Skarpaas (Crowder)
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
TitleResponsive Neurostimulation for Post-Traumatic Stress Disorder
Investigator
Jean-Philippe Langevin
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Post-traumatic stress disorder (PTSD) refractory to treatment is marked by failure of fear extinction and its
biological substrate, amygdala reactivity to trauma reminders13,14.
TitleRevealing neural computations through combined optical and electrical recordings
Investigator
Gregory Darin Field, Alexander Sher
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A major limitation to understanding the brain is a shortage of technologies for tracking the
activity of large populations of individual neurons across multiple layers of synaptic processing.
Ideally, these measurements of population activity would be compatible with both optogenetic
TitleRevealing the transcriptional and developmental mechanisms of interneuron identity
Investigator
Megan Crow
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Cortical GABAergic interneurons are critical components of neural circuitry, and their dysfunction has been
linked to neurodevelopmental diseases.
TitleScaling up spatial RNA profiling with compressed sensing
Investigator
Fei Chen, Yonina Eldar
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Single cell RNA-Seq (scRNA-Seq) and Imaging Transcriptomics (IT) methods have put a systematic
understanding of the brain and brain diseases through comprehensive 3-dimensional map of its constituent
cell types within reach.
TitleSelf-Image-Guided Flexible Ultrasonic Interrogation Platform for Neural Dust
Investigator
Mehdi Kiani
Institute
pennsylvania state university, the
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
Dynamic mapping of complex brain circuits by monitoring and modulating brain activity at a large scale will
enhance our understanding of brain functions, such as sensation, thought, emotion, and action.
TitleSensory recruitment by working memory: neuronal basis and neural circuitry
Investigator
Behrad Noudoost
Institute
university of utah
Fiscal Year
Funding Opportunities Number
Project Number
Working memory maintenance is fundamental for the orderly pursuit of goals in the
face of irrelevant, distracting stimuli.
TitleSingle cell isoform expression across mouse brain regions and development
Investigator
Hagen Ulrich Tilgner
Institute
weill medical coll of cornell univ
Fiscal Year
Funding Opportunities Number
Project Number
Single cell isoform expression across mouse brain regions and development
Much of the mouse brain's biology is defined by the action of long RNA and protein isoforms in distinct cell
types and brain regions.
TitleSingle cell transcriptional and epigenomic atlas of the macaque brain across the lifespan
Investigator
Michael L Platt, Jay Ashok Shendure, Noah Snyder-Mackler
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT / SUMMARY
New technologies are enabling molecular profiling of single brain cells at remarkable throughput.
TitleSingle Neuron Analyzer for Multi-modal, Cross-dataset (Epi)genomic Cell Type Datasets
Investigator
Eran A Mukamel
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Our project will create a computational resource, the Single Neuron Analyzer, to support the neuroscience
community’s efforts to build a reproducible, comprehensive, data-driven atlas of brain cell types.
TitleSpinal Circuits for the Control of Dextrous Movement
Investigator
Martyn D Goulding
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: Overall
Local networks within the spinal cord represent an essential computational layer for the control of limb-driven
motor behaviors, integrating descending and sensory inputs to coordinate dexterous motor output.
TitleSpinal Effects of Cortical Stimulation: Mechanisms and Functional Impact
Investigator
Jonathan Saul Carp, Yu Wang, Jonathan Rickel Wolpaw
Institute
wadsworth center
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Because activity-dependent plasticity is ubiquitous in the CNS, brain stimulation may have long-term effects on
areas to which the stimulated area connects. These effects have received little attention.
TitleStructural and functional connectivity of the social decision-making network
Investigator
Adam Steven Smith
Institute
university of kansas lawrence
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Humans and numerous other species live in complex social environments, requiring many of our most important
decisions to be made in the context of social interactions.
TitleStructural, single-cell transcriptomic, and functional 3-photon mapping of spinal pain circuits
Investigator
Prakash Kara, Suhasa B Kodandaramaiah, Lyudmila H Vulchanova
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Spinal dorsal horn interneurons (IN) integrate somatosensory inputs and control their access to spinal
projection neurons (PrN) that transmit nociceptive information to supraspinal components of pain pathways.
The heterogeneity of dorsal horn neurons, limited knowledge on their conne
TitleSubcellular Mapping and Post-Synaptic Impacts of Striatal Dopamine Release During Behavior
Investigator
Mai-Anh Vu
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The basal ganglia are a group of deep brain nuclei that play a central role in motivating, selecting, and learning
actions.
TitleTechnology development for closed-loop deep brain stimulation to treat refractory neuropathic pain
Investigator
Edward Chang, Philip Andrew Starr
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Many pain syndromes are notoriously refractory to almost all treatment and pose significant costs to patients
and society. Deep brain stimulation (DBS) for refractory pain disorders showed early promise but
demonstration of long-term efficacy is lacking.
TitleThalamic stimulation to prevent impaired consciousness in epilepsy
Investigator
Hal Blumenfeld
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
Impaired consciousness during seizures has a major negative impact on quality of life for people with epilepsy.
Consequences include risk of motor vehicle accidents, drowning, poor work and school performance, and
social stigmatization.
TitleThe cerebro-cerebellar-basal-gangliar network for visuomotor learning
Investigator
Stefano Fusi, Michael E. Goldberg, Peter Strick
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Visual learning is critical to the lives of human and non-human primates. Visuomotor association, the
assignment of an arbitrary symbol to a particular movement (like a red light to a braking movement), is a well-
studied form of visual learning.
TitleThe glial mechanism for electrical brain stimulation
Investigator
Hai-Long Wang, Gregory A Worrell, Long-Jun Wu
Institute
mayo clinic rochester
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT:
Electrical brain stimulation (EBS) is a FDA-approved neuromodulation therapy applied to several
neurological disorders. However, the molecular basis of its efficacy remains unclear.
TitleThe Neural Mechanism of Interval Timing in Drosophila
Investigator
Ashley Danielle Smart
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
There is no dedicated sensory organ for time, and yet our brains are able to use time to anticipate the
environment and adapt.