The goal of this proposal is to disseminate high resolution large volume serial section electron
microscopy data to neuroscientists.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleA Facility to Generate Connectomics Information
Investigator
Jeff W Lichtman
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
TitleA Fast, Accurate and Cloud-based Data Processing Pipeline for High-Density, High-Site-Count Electrophysiology
Investigator
Nathan G Clack, Bruce Kimmel
Institute
vidrio technologies, llc
Fiscal Year
Funding Opportunities Number
Project Number
The past decade has seen major advances in the tools available to neuroscientists, making it possible to ask
increasingly specific questions regarding which neurons and circuits are correlated with, necessary for, and
sufficient for, specific behavioral or computational functions.
TitleA fully biological platform for monitoring mesoscale neural activity
Investigator
Kafui Dzirasa
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
A fully biological platform for monitoring mesoscale neural activity
One of the barriers to understanding the human brain is due to its geometry. Accessing
brain tissue at single cell resolution has classically involved implanting electrodes (metallic or
optical) directly into the brain.
TitleA high-performance unshielded wearable brain-computer interface based on microfabricated total-field OPMs
Investigator
Jose Luis Contreras-Vidal, Svenja Knappe
Institute
university of houston
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: The broad, long-term goal of this project is to develop a wearable high performance MEG
system that can operate without external shielding that will lead to Advances in Human Neuroscience and
transformative advances in our understanding of the Human Brain ‘in Action and in Context’,
TitleA method for anterograde trans-synaptic tracing
Investigator
Donald B Arnold
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
Although considerable information about neuronal circuits has been generated from experiments where
retrograde transsynaptic tracing has been performed using Rabies Virus, there is no comparable technique for
transsynaptic tracing in the anterograde direction.
TitleA TOF, DOI, MRI compatible PET detector to support sub-millimeter neuroPET imaging
Investigator
Sergei Dolinsky, Robert S Miyaoka
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The overall goal of this research is to develop next generation positron emission tomography (PET) detector
technology to support non-invasive, quantitative brain imaging at spatial and temporal resolutions currently not
achievable with human neuro-PET systems.
TitleAChMRNS: Nanosensors for Chemical Imaging of Acetylcholine Using MRI
Investigator
Heather A Clark, Christopher A Flask
Institute
northeastern university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The neurotransmitter acetylcholine is widely distributed in the central nervous system and brain,
and is a key signaling molecule involved in neural function.
TitleAdvanced MOTEs: Injectable Microscale Optoelectronically Transduced Electrodes
Investigator
Jesse Heymann Goldberg, Paul Mceuen, Alyosha Christopher Molnar, Chris Xu
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Our goal is to develop a new class of electrophysiological recording devices, on the same physical scale as the
neurons they record, by combining modern imaging with implanted optoelectronics.
TitleAn open source, wireless, miniature microscope for monitoring neuronal activity
Investigator
Michele A Basso, Peyman Golshani
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Recent years have seen a boon in the development of new molecular, genetic and imaging tools designed to
dissect brain circuits that give rise to behavior in live animals.
TitleAn Ultra High-Density Virtual Array with Nonlinear Processing of Multimodal Neural Recordings
Investigator
Duygu Kuzum
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
An Ultra High-Density Virtual Array with Nonlinear Processing of Multimodal
Neural Recordings
A major goal of neuroscience is to record the activity of all neurons in an area of
an intact brain and understand the relationship between neural activity and behavior.
However, with current technologies
TitleAssessing the Effects of Deep Brain Stimulation on Agency
Investigator
Adina L Roskies
Institute
dartmouth college
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Recent advances in neurotechnologies have provided us with the ability to modulate brain function by
direct and indirect interventions.
TitleAuditory brain-computer interface for communication
Investigator
Daniel James Thengone
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A fundamental end-goal of brain-computer interfaces (BCI) is to enable communication in individuals
with severe motor paralysis. BCIs decode the neural signals and accomplish the intended goal via an effector,
such as a computer cursor or a robotic limb.
TitleAutonomously-activating bioluminescent reporters to enable continuous, real-time, non-invasive brain cell imaging
Investigator
Gary S Sayler
Institute
490 biotech, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Autonomously-activating bioluminescent reporters to enable continuous, real-time, non-
invasive brain cell imaging
Project Summary
This Small Business Innovation Research (SBIR) Phase I project proposes to develop a set of genetically encoded,
self-exciting bioluminescent (autobioluminescent) optic
TitleBidirectional Hybrid Electrical-Acoustic Minimally Invasive Implants for Large-Scale Neural Recording and Modulation
Investigator
Mehdi Kiani
Institute
pennsylvania state university, the
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
Dynamic mapping of complex brain circuits by monitoring and modulating brain activity at large scale will
enhance our understanding of brain functions, such as sensation, thought, emotion, and action.
TitleBidirectional optical-acoustic mesoscopic neural interface for image-guided neuromodulation in behaving animals
Investigator
Daniel Razansky, Dmitry Rinberg, Shy Shoham
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Neuroscience has an essential requirement for large-scale neural recording and
perturbation technologies for the understanding of brain function, as well as in the
diagnosis and treatment of neurological disorders.
TitleBoss: A cloud-based data archive for electron microscopy and x-ray microtomography
Investigator
Brock A. Wester
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Due to recent technological advances, it is possible to image the high-resolution structure of brain volumes at
spatial extents that are much larger than was previously possible.
TitleBrain-wide correlation of single-cell firing properties to patterns of gene expression
Investigator
Adam Ezra Cohen
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Brain-wide correlation of single-cell firing properties to patterns of gene expression
Every neuron expresses thousands of proteins which, through their interactions with each other
and with other small molecules, imbue the neuron with its functional properties.
TitleBreaking Spatiotemporal Barriers of MR Imaging Technologies to Study Human Brain Function and Neuroenergetics
Investigator
Wei Chen, Xiao-Hong Zhu
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Understanding how neural circuits operate and interconnect at mesoscopic (sub-millimeter) scale, and how
neuroenergetic metabolism and neurotransmitters support brain function at resting and working state is
essential to brain research and BRAIN Initiative. Magnetic
TitleBuilding analysis tools and a theory framework for inferring principles of neural computation from multi-scale organization in brain recordings
Investigator
Friedrich T Sommer
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
Summary
The BRAIN initiative is enabling ground-breaking techniques for brain recordings that
will permit a unique view onto the dynamics of neural activity. However, inferring brain
function from multi-channel physiological recordings is challenging.
TitleC-PAC: A configurable, compute-optimized, cloud-enabled neuroimaging analysis software for reproducible translational and comparative
Investigator
Richard Cameron Craddock, Michael Peter Milham
Institute
child mind institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The BRAIN Initiative is designed to leverage sophisticated neuromodulation, electrophysiological recording,
and macroscale neuroimaging techniques in human and non-human animal models in order to develop a
multilevel understanding of human brain function.