PROJECT SUMMARY
Technology for recording from the brain is developing at a breakneck pace.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleData interface and apps for systems neurophysiology and imaging
Investigator
Stephen D Van Hooser
Institute
brandeis university
Fiscal Year
Funding Opportunities Number
Project Number
TitleData-driven analysis for neuronal dynamic modeling
Investigator
Gal Mishne
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Our main goal is to unravel communication dynamics in the brain, as they relate to various sensory-motor
actions and to the learning process. The sensory-motor system operates through the concerted interaction of
multiple closed-loops feedback systems.
TitleDEEPHIPPO: Ultra-thin lensless endoscope for the visualization of deep hippocampus neuronal functional activity.
Investigator
Herve Rigneault
Institute
aix-marseille university
Fiscal Year
Funding Opportunities Number
Project Number
Rigneault Project Abstract DEEPHIPPO
DEEPHIPPO: Ultra‐thin lensless endoscope for the visualization of deep
hippocampus neuronal functional activity.
Principal investigator: Hervé Rigneault
Host Institution: Aix‐Marseille University, Marseille, France
Project duration : 24 months
Project Abstract
D
TitleDELINEATING CELL-SPECIFIC OUTPUT PATHWAYS OF THE GPe THAT SUPPORT LONG-LASTING BEHAVIORAL RECOVERY IN DOPAMINE DEPLETED MICE
Investigator
Aryn Hilary Gittis
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
A major challenge in the treatment of neurological diseases is the elaborate and diffuse nature of neural
circuits, where physically proximal neurons are engaged in functionally different pathways. The ability to target
neurons based on function, rather than location, is critical to im
TitleDendritome mapping of genetically-defined and sparsely-labeled cortical and striatal projection neurons
Investigator
Hong-Wei Dong, Xiangdong William Yang
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Integrating molecular, morphological, and connectomic properties is critical for unbiased
classification of neuronal cell types in the mammalian brain.
TitleDesigning low-cost, customizable high-density probes for acute and chronic neural recordings in rodents
Investigator
Ingrid Van Welie
Institute
neural dynamics technologies inc.
Fiscal Year
Funding Opportunities Number
Project Number
SF424 – Project Summary
Understanding how the brain generates certain behaviors requires an understanding of
the function of individual neurons in dynamical neural circuits.
TitleDevelopment and Translation of an Intracranial Auditory Nerve Implant
Investigator
Robert Kyle Franklin, Thomas Lenarz, Hubert Hyungil Lim, Andrew J. Oxenham, Loren Rieth, Florian Solzbacher
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The proposed project will build and evaluate the safety and design needs of a new type of intracranial auditory
prosthesis that targets the auditory nerve between the cochlea and the brainstem (auditory nerve implant, ANI)
in order to substantially improve hearing performance over the curre
TitleDevelopment of 7-T MR-compatible TOF-DOI PET Detector and System Technology for the Human Dynamic Neurochemical Connectome Scanner
Investigator
Ciprian Catana
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We seek support to develop and build the positron emission tomography (PET) detector module for the next
generation 7-Tesla magnetic resonance (MR)-compatible PET brain scanner with dramatically improved
spatio-temporal resolution.
TitleDevelopment of a Revolutionary MRI System for Functional Brain Imaging
Investigator
Bob S Wagner, Sou-Tien Bert Wang
Institute
wang nmr, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
It is the dream of researcher's and clinician's to have available a low cost, portable MRI scanner for brain
neuroimaging. However, such a low cost MRI system requires a small bore MRI magnet.
TitleDevelopment of predictive coding networks for spatial navigation
Investigator
George Dragoi
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Development of predictive coding networks for spatial navigation
Summary: Mammalian navigation uses internal models to predict the spatial-temporal statistical regularity of
the sequence of environmental locations.
TitleDiscovering dynamic computations from large-scale neural activity recordings
Investigator
Tatiana Engel
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
How neural activity is coordinated within local microcircuits and across brain regions to drive behavior is
a central open question in neuroscience.
TitleDissecting corticostriatal circuitry underlying chronic binge eating
Investigator
Britny Hildebrandt
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Eating disorders are severe psychiatric conditions with a significant worldwide cost and disability burden. Binge
eating (BE) is a behavior that cuts across nearly all eating disorder diagnoses.
TitleDual-channel Sub-millisecond Resolution Neural Imaging System
Investigator
Youbo Zhao
Institute
physical sciences, inc
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The investigation of the complex neural dynamics and the cognitive functions of the brain requires non-
invasive recording tools with high spatio-temporal resolution.
TitleDynamics and Causal Functions of Large-Scale Cortical and Subcortical Networks
Investigator
Gerwin Schalk
Institute
wadsworth center
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Improved understanding of the brain processes underlying normal and abnormal function is necessary for
devising better ways to diagnose, alleviate, or cure neurological or psychiatric disorders.
TitleEarly Feasibility Clinical Trial of a Visual Cortical Prosthesis
Investigator
Jessy D Dorn, Robert Jay Greenberg, Nader Pouratian
Institute
second sight medical products, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Blindness in the United States is a large and increasing problem. Any significant vision loss is
debilitating, but profound blindness is devastating to an individual’s ability to be independent
and to perform everyday tasks and activities.
TitleElucidating the Wiring and Rewiring of Poly-synaptic Memory Circuits by Directed Stepwise Trans-neuronal Tracing
Investigator
Wei Xu
Institute
ut southwestern medical center
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Multimodal sensory information is converged through poly-synaptic pathways to the
hippocampus to form integrated representations and encode memories of the world, which in
turn guide our future behavior through multiple poly-synaptic downstream pathways.
TitleEnabling Multi-Tracer SPECT Studies of the Human Brain
Investigator
Todd E Peterson
Institute
vanderbilt university medical center
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Molecular imaging provides the means to quantitatively study many types of processes in the human brain in a
minimally invasive manner.
TitleEpigenetic tools and resources for cell-type and spatial analysis of individual mammalian non-neuronal cells
Investigator
Andrew Adey
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The mammalian brain is an enormously complex organ with myriad cell types cohesively working together to
carry out a host of intricate tasks, from motor functions, to the storing and execution of consciousness.
TitleFast Spatial Light Modulators for Neuronal Excitation and Imaging
Investigator
Andrei Faraon
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: We propose to develop fast spatial light modulators (SLM) to address the
need for optical hardware compatible with the current fast genetically encoded sensors and
actuators.
TitleFast volumetric imaging of large areas in deep brain
Investigator
Timothy Holy
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
One of the central goals of the BRAIN initiative is to develop and disseminate methods for
imaging activity in large populations of neurons at high speeds. Of the available techniques,
one of the most promising is light sheet microscopy.