A Brain Circuit Program for Understanding the Sensorimotor Basis of Behavior
Abstract
The Project team's long-term goal is to develop a comprehensive theory of animal behavior that explicitly
incorporates neural processes operating across hierarchical levels — from circuits that regulate the action
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleA Brain Circuit Program for Understanding the Sensorimotor Basis of Behavior
Investigator
Thomas Robert Clandinin, Michael H Dickinson, Shaul Druckmann, Richard S Mann, Richard M Murray, John Tuthill, Rachel Wilson
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
TitleA BRAIN Initiative Resource: The Neuroscience Multi-omic Data Archive
Investigator
Owen R White
Institute
university of maryland baltimore
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative
promotes the development and application of technologies to describe the temporal and spatial
dynamics of cell types and neural circuits in the brain.
TitleA Cellular Resolution Census of the Developing Human Brain
Investigator
Eric J Huang, Arnold Kriegstein
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
We aim to create a spatiotemporal single cell resolution map of the developing human neocortex in order to
establish how many distinct cell types are present and to unravel their complex developmental history.
TitleA Community Resource for Single Cell Data in the Brain
Investigator
James C Gee, Michael Hawrylycz, Maryann E Martone, Lydia Lup-Ming Ng, Anthony Philippakis
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A detailed census of the structure and role of cell type specific data in the brain is recognized as one of the most
promising avenues for advancing our understanding of the human brain in health and disease.
TitleA Confocal Fluorescence Microscopy Brain Data Archive
Investigator
Marcel P Bruchez, Alexander J Ropelewski, Simon C Watkins
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Advancements in the field of microscopy and imaging have pushed the boundaries of what
was once thought possible in many fields of research.
TitleA General Approach for the Development of New Cell-Type-Specific Viral Vectors
Investigator
Michael Eldon Greenberg
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
Our limited ability to genetically access specific cell types within the nervous system constitutes a fundamental
impediment in our efforts to probe brain function and intervene therapeutically, particularly in species lacking
the well-developed genetic resources available in the mo
TitleA magnetic particle imager (MPI) for functional brain imaging in humans
Investigator
Lawrence L Wald
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
In this U01 grant we propose a 5 year engineering development effort to advance Magnetic
Particle Imaging (MPI) to replace MRI as the next-generation functional brain imaging tool for human
neuroscience.
TitleA microscope optimized for brain-scale 2-photon imaging
Investigator
Bijan Pesaran
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
This proposal presents an academic-industrial partnership to develop an instrument for 2-photon laser
scanning microscopy (2p-LSM) in non-human primates (NHP) for transformative basic science and clinical
translation.
TitleA Molecular and Cellular Atlas of the Marmoset Brain
Investigator
Guoping Feng
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
The complexity of the mammalian brain is unparalleled by any other organ, and understanding its
cellular composition is essential to understand how it gives rise to cognition and behavior.
TitleA multimodal atlas of human brain cell types
Investigator
Ed Lein
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Abstract:
A Multimodal Atlas of Human Brain Cell Types
Cell types are the building blocks of the brain, including the neuron types forming specific neuronal
circuits responsible for perception, cognition and action, and the non-neuronal elements performing other
essential roles for proper brain fun
TitleA novel platform for genetically-encoded optical neuropeptide sensors (NEONS)
Investigator
Matthew Ryan Banghart, Geoffrey A Chang
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Neuromodulators play an important role in our life by dynamically adapting the brain to an ever-changing
environment.
TitleA whole-brain ultrasonic neural stimulation and photoacoustic recording system in behaving animals
Investigator
Omer Oralkan, Mesut Sahin
Institute
north carolina state university raleigh
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
Decoding the electrical and chemical signals in neural circuits is essential to understand the
communication between different brain regions and how these neural networks give rise to a particular function
at the level of the whole organism.
TitleAccessing the Neuronal Scale: Designing the Next Generation of Compact Ultra High Field MRI Technology for Order-of-Magnitude Sensitivity Increase in Non-Invasive Human Brain Mapping
Investigator
Brian Keith Rutt
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A complete understanding of both normal brain function and neurological disorders / mental illness will
require the deciphering of the complex brain networks that underlie behavior and cognition, at both whole-brain
and microscopic scales.
TitleAchieving ethical integration in the development of novel neurotechnologies
Investigator
Winston Chiong
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
New technologies that modulate brain function have tremendous potential for alleviating the persistent burden
of depression and other neuropsychiatric disorders, but also raise challenging ethical and societal questions
regarding self-ownership and control over our thoughts,
TitleAn academic industrial partnership for the development of high frame-rate transcranial super resolution ultrasound imaging
Investigator
Paul A Dayton, Gianmarco Pinton
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Very recently, the revolutionary technology of contrast enhanced super-resolution ultrasound imaging has been
developed.
TitleAn anatomical cell type atlas of gene expression, morphology and connectivity
Investigator
Hongkui Zeng
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary (Research Segment 2)
The brain circuit is an intricately interconnected network of numerous cell types.
TitleAnatomical characterization of neuronal cell types of the mouse brain
Investigator
Giorgio A Ascoli, Hong-Wei Dong, Byungkook Lim
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY AND ABSTRACT
A comprehensive understanding neuronal cell type diversity is an essential guide to selective manipulation and
illuminating cell type specific functional contributions toward health and disease.
TitleAnatomy
Investigator
Z Josh Huang
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
ANATOMY RESEARCH SEGMENT SUMMARY
The overarching goal of neuroanatomy is to establish a structural framework to integrate multiscale and
multi-modal information and to provide a road map that guides the exploration of neural dynamics and brain
function. “Anatomic” neuron types
TitleBehavioral state modulation of sensorimotor processing in cerebellar microcircuits
Investigator
Shane A Heiney
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Moment-to-moment fluctuations in behavioral and brain states have been shown to have profound effects on
perception and behavior in both humans and experimental animals.
TitleBIDS-Derivatives: A data standard for derived data and models in the BRAIN Initiative
Investigator
Russell A Poldrack
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The effective sharing of data requires the development and broad adoption of standards for the
organization of data and metadata.