Funded Awards

PROJECT SUMMARY DESCRIPTION (provided by applicant): Changes in membrane potential are the fundamental language of the nervous system, but these voltage signals are not directly visible.

Electrocortical stimulation (ECS) has been used for functional mapping for many decades to identify brain areas that are “critical” for speech and language (i.e., that impair function when stimulated) prior to epilepsy or tumor surgery.

Summary: Behavioral data is central to biomedical research, including both synchronous measures (e.g. brain activation and button-presses from a reading task in an fMRI scan), and those performed independently (e.g.

Over the past 15 years, new microscope technologies and methods for high throughput imaging have revolutionized structural biology by extending the resolution and scale of datasets in 3 dimensions.

Project Summary Visual attention differences are a promising diagnostic marker for autism spectrum conditions (ASC).

Neuroimaging methods such as functional MRI and magneto- / electroencephalography (MEG/EEG) cannot directly reveal causal relationships between regional brain activity and behavior.

Motivation and Objectives Why are ion channels localized in subcellular dendritic compartments and is there a tight coupling of the observed localization with neuron function?

PROJECT SUMMARY The cerebellum has long been thought to solely process motor information. Yet, there is a growing literature that points to a role of the cerebellum in processes across multiple domains.

Reading involves complex transformations of word forms, with visual input mapped to lexical, semantic and phonological systems in less than a second.

Project Summary: High frequency oscillations (HFOs) of intracranial EEG (iEEG) have the potential to identify the surgical resection area/seizure onset zone (SOZ) in patients with drug resistant epilepsy.

Project Summary Reward is often present in risky environments, requiring individuals to weigh the benefits of rewards against the associated risks. There are several psychiatric disorders in which patients are unable to choose an appropriate response during risky reward opportunities.

Project Abstract/Summary This application describes a 3-year training plan that will enable me, a cognitive neuroscientist with prior training in electroencephalography (EEG), to conduct research on contextual memory representation using neuroimaging (fMRI) and computational modeling.

Over the past 15 years, new imaging technologies and methods for high throughput imaging have revolutionized structural biology by extending the resolution and scale of collected images in 3 dimensions.

PROJECT SUMMARY The basic mechanisms underlying comprehension of spoken language are unknown. We are only beginning to understand how the human brain extracts the most fundamental linguistic elements (consonants and vowels) from a complex and highly variable acoustic signal.

PROJECT SUMMARY/ABSTRACT Animals exhibit a remarkable array of creative, adaptive, and flexible behaviors.

We experience the world as a continuous sequence of events, but we remember the events as segmented episodes (e.g., my sister’s wedding). During encoding, we associate a sequence of relevant events and segment deviant events.

Abstract The goal of this project is to develop an archival data format and a formal task specification language to serve as standards for describing behavioral experiments.

Understanding the function of the nervous system requires a sophisticated understanding of its main output, behavior.

PROJECT SUMMARY Technology for recording from the brain is developing at a breakneck pace.