PROJECT SUMMARY To understand complex neural pathways and networks and their remarkable ability to generate human behaviors, it is critical to precisely map brain connectomics in vivo.
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
SUMMARY This ambitious proposal will establish an integrated experimental-computational platform to create the first comprehensive brain-wide mesoscale connectivity map in a non-human primate, the common marmoset (Callithrix jacchus),.
Project Summary Mapping the brain-wide connections of neurons provides a foundation for understanding the structure and functions of a brain.
Project Summary/Abstract (30 lines of text limit) The ~1 billion neurons that form the human brainstem are organized at multiple scales, ranging from their cell type-specific patterns of dendritic arborization, to local circuits embedded within large-scale projection systems spanning the brainste
Project Summary/Abstract Volume electron microscopy is the only technique to-date that provides both sufficient resolution (100 μm) for the dense reconstruction of neuronal wiring diagrams.
Project Summary / Abstract Upcoming brain-wide descriptions of synaptic connectivity are poised to transform our understanding of brain circuitry in the same way single-cell genomics has revolutionized our understanding of cell type diversity.
SUMMARY High-throughput connectomics is needed to generate the TB-, PB- and EB-scale wiring diagrams of mammalian brains, but is limited to the few research institutes (e.g., Janelia, Allen, Max Planck) with sufﬁcient infrastructure.
ABSTRACT Single-cell transcriptomics has revolutionized our understanding of neuronal diversity and enabled high-throughput characterization of molecular cell types across brain areas and species.
Project summary: This project will develop and validate a comprehensive toolset of novel technologies for imaging axonal projections across scales, and will deploy this toolset to map a complex system of cortico- subcortical projections in the macaque and human brain.
Abstract The hippocampus has a well-established role in the initial formation and storage of memory. However, little is understood about brain mechanisms that support the re-organization and transfer of memories into longer-term cortical storage.
Abstract This project aims to develop the first Inverse Activity Marker (IAM) for detecting neuronal inhibition (broadly defined as the decrease of neuronal activities).
PROJECT SUMMARY/ABSTRACT Individuals make choices and prioritize actions using complex processes that assign value to rewards and associated stimuli based on prior experience.
PROJECT SUMMARY Sensory representations are influenced by an animal’s external context, internal state, past experiences, expectations, and future goals.
A central goal of neuroscience is to discover how neural circuits control the body’s muscles to produce behavior.
PROJECT SUMMARY/ABSTRACT After a stroke, walking ability can be compromised, which can lead to reduced quality of life and decreased ability to perform activities of daily living.
Many animals rely on their ability to navigate to the source of airborne odor plumes for survival. Studies dating back a century have shown that insects combine mechanosensory and olfactory cues to navigate, surging upwind when detecting odor but go crosswind or downwind when losing the signal.
PROJECT SUMMARY DESCRIPTION (provided by applicant): Changes in membrane potential are the fundamental language of the nervous system, but these voltage signals are not directly visible.
PROJECT SUMMARY The insular cortex (IC) is a multimodal hub that integrates interoceptive and exteroceptive information to control diverse aspects of animal behaviors related to cognition, emotion, and motivation.
PROJECT SUMMARY Animals can exhibit goal-directed behaviors in novel environments, despite limited experience with them. How does the brain make and use inferences about the underlying statistics and generative structure of environments to guide behavior?
ABSTRACT ‒ UG3/UH3 Deep Brain Stimulation (DBS), applied to areas like the subthalamic nucleus (STN), is a standard treatment for Parkinson Disease (PD), however, DBS has inherent surgical risks as well as potential for infections and adverse side effects.