PROJECT SUMMARY
The choroid plexus (ChP) is a vital tissue located in each ventricle in the brain.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleA Functional and Selective Toolkit for Choroid Plexus Networks
Investigator
Maria Lehtinen, Christopher I Moore
Institute
boston children's hospital
Fiscal Year
Funding Opportunities Number
Project Number
TitleA genetically Encoded Method to Trace Neuronal Circuits in the Zebrafish Brain
Investigator
Carlos Lois, David Aaron Prober
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
It is widely thought that identifying how neurons are connected to each other in a brain circuit, its wiring
diagram, is a necessary step towards understanding how brain activity gives rise to behavior, and how it is
perturbed by disease.
TitleA Massive Library of AAVs to Target Transcriptionally-Defined Primate Cell Types
Investigator
William Richard Stauffer
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Here we will identify nonhuman primate (NHP) neuron types and build an extensive toolbox of vectors for circuit-
based neuroscience studies.
TitleA multimodal platform to bridge the experimental gap between behavioral, neuronal, and molecular studies
Investigator
Dawen Cai, Meng Cui
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Depicting the specific neuronal identity and connectivity underlying particular brain function remains
a central goal for neuroscience.
TitleA Neural Systems Approach to Understanding the Dynamic Computations Underlying our Sense of Direction
Investigator
Jeffrey Steven Taube, Matthijs Van Der Meer
Institute
dartmouth college
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The Research Plan describes a series of experiments that will examine how spatial information is
processed in the mammalian brain.
TitleA new approach to biological recording of lineage hierarchy in primate brains
Investigator
Ali H Brivanlou
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
!
Most genetic recorders described so far utilize the CRISPR/Cas9 system to leave a unique genetic scar in
each cell that can be traced in daughter cells.
TitleA novel platform for the investigation of human microglia
Investigator
Mathew Mark Blurton-Jones, Robert C Spitale
Institute
university of california-irvine
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
To accomplish their diverse maintenance and protective roles, microglia must be extremely plastic, dynamically
sensing and responding to specific local challenges throughout the brain.
TitleA SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM
Investigator
Ravi Srinivasan
Institute
advanced imaging research, inc.
Fiscal Year
Funding Opportunities Number
Project Number
NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System
The intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using
magnetic resonance imaging (MRI).
TitleA system for whole-brain recording and control of activated neurons with near-infrared light
Investigator
Daria Shcherbakova
Institute
albert einstein college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT:
The brain simultaneously processes tremendous amount of information using billions of neurons.
Technologies for large scale recording and modulation of neurons in the brain of behaving animals
sought by this RFA should provide researchers with tools to correlate neural circuits with behavi
TitleA Technology Resource for Polymer Microelectrode Arrays
Investigator
Ellis Meng, Dong Song
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
The purpose of this proposal is to disseminate polymer microelectrode arrays and promote their
integrated into neuroscience research practice.
TitleA unified framework to study history dependence in the nervous system
Investigator
Fidel Santamaria
Institute
university of texas san antonio
Fiscal Year
Funding Opportunities Number
Project Number
The brain uses its own previous activity to adapt to an ever-changing environment. This history
dependent adaptation takes place at all scales of organization of the nervous system.
TitleA wearable functional-brain-imaging system with full-head coverage and enhanced spatiotemporal-resolution to study complex neural circuits in human subjects
Investigator
Peter D. D. Schwindt
Institute
sandia corp-sandia national laboratories
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
To develop maps at multiple scales of neuronal circuits in the human brain and study the brain dynamics, there
is a need for non-invasive functional brain imaging with high spatiotemporal resolution operating in natural
environments.
TitleA wearable high-density MEG system with uOPMs
Investigator
Orang Alem
Institute
fieldline, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
This Phase I project will focus on developing key elements needed to achieve a wearable, high-density,
magnetoencephalography (MEG) device based on optically-pumped atomic magnetometers (OPMs).
OPM sensors have progressed to be comparable in sensitivity to liquid-helium-cooled superconducti
TitleAccessible technologies for high-throughput, whole-brain reconstructions of molecularly characterized mammalian neurons
Investigator
Michael I Miller, Ulrich Mueller
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
The BRAIN Initiative seeks to accelerate the development and application of innovative technologies that
ultimately will revolutionize our understanding of the human brain.
TitleAccurate and reliable computational dosimetry and targeting for transcranial magnetic stimulation
Investigator
Luis Javier Gomez
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Transcranial magnetic stimulation (TMS) is a noninvasive technique used for neuroscience research and
treatment of psychiatric and neurological disorders. During TMS, a current-carrying coil placed on the scalp
induces an electric field that modulates targeted neuronal circuits.
TitleAcoustically targeted molecular control of cell type specific neural circuits in non-human primates
Investigator
Mikhail Shapiro, Doris Ying Tsao
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
Controlling specific neural circuits across large areas of the brain is a major technology goal of the BRAIN
Initiative.
TitleADVANCED NEXT GEENRATION RADIO FREQUENCY COILS FOR MAGNETIC RESONANCE IMAGING
Investigator
Ravi Srinivasan
Institute
advanced imaging research, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Magnetic resonance imaging (MRI) is a safe, non-ionizing diagnostic tool. The overall goal of this
project is to arrive very close to the ultimate intrinsic signal to noise ratio (UISNR) for a given MRI
magnet field strength by combining innovations in very advanced transceiver technology.
TitleAn open software solution to integrate non-invasive brain stimulation with functional imaging data
Investigator
Alexander Opitz
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Noninvasive tools capable of selectively manipulating neural systems in the human brain are needed to
advance our neuroscientific understanding of brain function and develop novel non-pharmacologic
psychotherapeutics and are a major focus of Brain Initiative funding.
TitleAn optogenetic brain implant with EEG monitoring and response for mice
Investigator
Kevan Sayed Hashemi
Institute
open source instruments, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Abstract: Optogenetics can be used to selectively stimulate or suppress the firing of genetically
targeted and spatially targeted mammalian neurons. It is used to study neuropsychiatric
diseases in vivo with mouse models of conditions including epilepsy, schizophrenia, and
Parkinson's.
TitleAutomating whole brain connectomics: development, validation, and application of an open toolkit
Investigator
Davi Bock
Institute
university of vermont & st agric college
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
We have recently published a 3D electron microscopy volume of the whole fruit fly brain. However mapping of
synaptic `wiring diagrams' or connectomes of neuronal circuits from this volume is currently completely manual
and therefore slow.