PROJECT SUMMARY/ABSTRACT Multiphoton microscopy of cells labeled with genetically encoded calcium indicators (GECIs) enables detection and correlation of fine neuronal structure to functional activity with cellular resolution.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleAn Autonomous Rapidly Adaptive Multiphoton Microscope for Neural Recording and Stimulation
Investigator
Mark A Foster
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
TitleDistinct contributions of converging neural pathways to auditory learning
Investigator
Santiago Jaramillo, James Murray
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Effective interpretation of sensory stimuli relies on the ability to discriminate stimulus features and link them to appropriate behavioral responses depending on past experience.
TitleIntegrative Analysis of Adaptive Information Processing and Learning-Dependent Circuit Reorganization in the Auditory System
Investigator
Wiliam Mcintyre Debello, Mark H Ellisman, Brian J Fischer, Jose L Pena
Institute
albert einstein college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Abstract Decades of research have revealed the principles of information processing that give rise to auditory spatial tuning and experience-dependent adaptive plasticity in the owl auditory system.
TitleNeural Recording and Simulation Tools to Address the Mesoscale Gap
Investigator
John Compton Mosher, Charles E Schroeder, John P Seymour
Institute
university of texas hlth sci ctr houston
Fiscal Year
Funding Opportunities Number
Project Number
Abstract We have designed a novel approach to perform multi-scale recordings in the brain across regions and depths.
TitlePostnatal experience shapes gene expression and connectivity development in the cortex
Investigator
Alexander Nevue
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Postnatal sensory experience has a profound effect on the maturation, composition, and connectivity of cortical cell types, but systematic analyses of these changes have not yet been feasible.
TitleScaling Volumetric Imaging, Analysis and Science Communication Using Immersive Virtual Reality
Investigator
Gianfranco Doretto, Michael David Morehead, George A Spirou
Institute
istovisr
Fiscal Year
Funding Opportunities Number
Project Number
Over the past 15 years, new microscope technologies and methods for high throughput imaging have revolutionized structural biology by extending the resolution and scale of datasets in 3 dimensions.
TitleAcoustic modulation of forebrain aggression network in miniature, transparent vocal fish
Investigator
Andrew H Bass
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
Assessing social signals, such as vocalizations, figures prominently in the outcome of aggressive encounters,
including the potential to win a fight or prevent escalation resulting in physical injury.
TitleCortical circuits for the integration of parallel short-latency auditory pathways
Investigator
Hiroyuki Kato, Paul B Manis
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
How our brain achieves coherent perception by integrating information from parallel sensory pathways
distributed across space and time remains a central question in neuroscience.
TitleHighly parallel long wavelength heterodyne diffuse correlation spectroscopy for brain functional imaging
Investigator
Stefan Alexandru Carp
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Non-invasive imaging of human brain function plays an important role in advancing neuroscience research and
understanding neurological diseases. This need has been met primarily by functional magnetic resonance
imaging (fMRI).
TitleHormonal regulation of sensory processing during parental care
Investigator
Kristina O. Smiley
Institute
university of massachusetts amherst
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Does the way we hear sounds change when we become parents?
TitleInvestigating the pathomechanisms underlying Charcot-Marie-Tooth Disease
Investigator
Julia Alexis Jones
Institute
scripps research institute, the
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Charcot-Marie-Tooth (CMT) disease is a genetically and clinically heterogeneous group of
inherited peripheral neuropathies that is characterized by damage to long motor and sensory
axons.
TitleThe interaction of cortical and subcortical processing in natural sensory behavior
Investigator
Cristopher M Niell, Michael Wehr
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Our brains have evolved to extract relevant sensory information from rich and complex natural environments in
order to drive appropriate behavior.
TitleThe Spatial and Temporal Scale of Neuromodulation in Mouse Sensory Cortex
Investigator
Jacob Reimer
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
The neuromodulators acetylcholine (ACh) and norepinephrine (NE) are associated with an
activated cortical brain state characterized by an increase in the reliability of cortical responses
to external stimuli and enhanced performance on behavioral tasks.
TitleUnderstanding how cortex supports flexible sensory representations
Investigator
Katherine Charlotte Wood
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Learning is a fundamental function of the brain: sensory representations must be flexible to adjust to changes in
environmental demands and experience, thus allowing us to adapt to the world around us.
TitleCell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
Investigator
Anton Arkhipov, Li-Huei Tsai
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
Patterned sensory stimulation (PSS) is a non-invasive technique for manipulating brain activity and states,
typically employing periodic light flicker or auditory tones presented at regular intervals.
TitleCRCNS: The Role of Statistical Structure for Natural Sound Recognition in Noise
Investigator
Monty A Escabi
Institute
university of connecticut storrs
Fiscal Year
Funding Opportunities Number
Project Number
The ability to listen and identify sounds in the presence of competing background noise is a critical function of the healthy auditory system.
TitleNeural mechanisms of multisensory auditory-olfactory integration in the auditory cortex
Investigator
Nathan Vogler
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Living organisms interact with complex environments that are inherently multisensory. Within these
environments, the brain must integrate information from multiple sensory modalities, including the auditory and
olfactory systems, for perception and behavior.
TitleRobotically-actuated, low-noise, concurrent TMS-EEG-fMRI system
Investigator
Chunlei Liu, Michael Lustig, Angel V Peterchev
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The ability to noninvasively modulate and image the brain with spatial and temporal precision is highly desirable
for understanding brain circuits in health and disease.
TitleAn integrated platform for studying sensory networks in the vertebrate brain
Investigator
Ethan Kime Scott
Institute
university of queensland
Fiscal Year
Funding Opportunities Number
Project Number
7. Project Summary/Abstract
Human experience is shaped by our senses, which receive diverse inputs from our
environment. These varied inputs, however, all contribute to a single integrated
representation in our minds of the outside world.
TitleCortical circuitry supporting flexible audiovisual interactions and behaviors
Investigator
Andrea Rayne Hasenstaub
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Interactions between the auditory and visual systems are among the most well-established cases of
crossmodal interplay, yet the overwhelming bulk of the sensory physiology literature reflects studies examining
processing confined to a single modality and we understand comparatively l