DESCRIPTION (provided by applicant): Perceptual decision-making involves multiple cognitive components and diverse brain regions.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleCortical circuits and information flow during memory-guided perceptual decisions
Investigator
Mriganka Sur
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
TitleCrowd coding in the brain:3D imaging and control of collective neuronal dynamics
Investigator
Patrick O Kanold, Wolfgang Losert, Dietmar Plenz
Institute
univ of maryland, college park
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The cortex is a laminated structure that is thought to underlie sequential information processing.
TitleDefining cell types, lineage, and connectivity in developing human fetal cortex
Investigator
Daniel H Geschwind
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Little is currently known about the number, proportion, or lineage of distinct cell types in the developing human fetal brain.
TitleDeveloping drivers for neuron type-specific gene expression
Investigator
Oliver Hobert
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Driver lines that direct Cre protein to specific neuron types have proven to be invaluable tools to not only visualize specific neuron types but also to manipulate their activity through the Cre- mediated activation of optogenetic probes or to assess gene fu
TitleDevelopment of Protein-based Voltage Probes
Investigator
Vincent A Pieribone
Institute
john b. pierce laboratory, inc.
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The use of genetically encoded fluorescent activity probes represent the most advanced method to monitor the electrical activity of networks of neurons without using electrodes.
TitleDissecting human brain circuits in vivo using ultrasonic neuromodulation
Investigator
Mikhail Shapiro, Doris Ying Tsao
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): A dream of neuroscience is to be able to non-invasively modulate any given region of the human brain with high spatial resolution.
TitleDREADD2.0: AN ENHANCED CHEMOGENETIC TOOLKIT
Investigator
Jian Jin, Thomas L. Kash, Bryan L. Roth
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative has the ambitious goal of elucidating how neuronal ensembles interactively encode higher brain processes.
TitleEpigenomic mapping approaches for cell-type classification in the brain
Investigator
M Margarita Behrens, Joseph R Ecker
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Understanding the exact cell-type composition in brain regions is fundamental to integrating physiological, behavioral and neurochemical data to systematically understand the brain structure and function.
TitleEstablishing a Comprehensive and Standardized Cell Type Characterization Platform
Investigator
David J Anderson, Hongkui Zeng
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The brain circuit is an intricately interconnected network of a vast number of neurons with diverse molecular, anatomical and physiological properties. Neuronal cell types are fundamental building blocks of neural circuits.
TitleFAST HIGH-RESOLUTION DEEP PHOTOACOUSTIC TOMOGRAPHY OF ACTION POTENTIALS IN BRAINS
Investigator
Lihong Wang
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Revealing how our brain works is a great challenge but yet worth our every effort: it will not only illuminate the profound mysteries in science but also provide the key to understanding and treating neurological diseases such as Alzheimer's and Parkinson's
TitleGenetically encoded reporters of integrated neural activity for functional mapping of neural circuitry
Investigator
Kit S Lam, James S Trimmer
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): One of the major challenges in neuroscience is to link the structure to the function of neural circuits.
TitleGenetically encoded sensors for the biogenic amines: watching neuromodulation in action
Investigator
Lin Tian
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The goal of this proposal is to develop a toolbox of genetically encoded indicators for biogenic amines, the most important family of neuromodulators.
TitleHigh-Density Recording and Stimulating Microelectrodes
Investigator
Timothy James Gardner
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): This project seeks to develop a high density, minimally invasive electrode array for long-term recording and control of brain activity.
TitleIdentification of enhancers whose activity defines cortical interneuron types
Investigator
John L. R. Rubenstein, Vikaas Singh Sohal
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Molecular definitions of neural cell types largely depend on the expression of RNAs or proteins as assessed by in situ hybridization, RNA array and sequencing, and immunohistochemistry.
TitleImaging Brain Function in Real World Environments & Populations with Portable MRI
Investigator
Michael Garwood, John T Vaughan
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Functional magnetic resonance imaging (fMRI) continues to play a critical role in understanding the human brain.
TitleImaging in vivo neurotransmitter modulation of brain network activity in realtime
Investigator
Albert Gjedde, Arman Rahmim, Dean Foster Wong
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neuronal depolarization and neurotransmitter release underlie some of the most fundamental components of normal physiology and the etiology of brain pathophysiology.
TitleImaging the Brain in Motion: The Ambulatory Micro-Dose, Wearable PET Brain Imager
Investigator
Julie Ann Brefczynski-Lewis
Institute
west virginia university
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Our vision is to design the first truly mobile molecular brain imager that can be used on healthy subjects to study the functioning of the human brain during motion.
TitleIn-vivo circuit activity measurement at single cell, sub-threshold resolution
Investigator
Craig Forest, Garrett B. Stanley
Institute
georgia institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): Neurons communicate information through fluctuations in the electrical potentials across their cellular membranes.
TitleIntegrative Functional Mapping of Sensory-Motor Pathways
Investigator
Michael H Dickinson, Philip J Holmes, Richard S Mann, Rachel Wilson
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): The goal of the project team is to develop a robust, multi-lab research framework, enabled by large scale imaging, which will lead to principled integrative models of ethologically-relevant behaviors that incorporate a detailed knowledge of individual cell c
TitleLarge-Scale Electrophysiological Recording and Optogenetic Control System
Investigator
Albert Baldwin Goodell
Institute
graymatter research
Fiscal Year
Funding Opportunities Number
Project Number
DESCRIPTION (provided by applicant): In order to gain a greater understanding of the neural mechanisms that mediate human cognitive function new approaches and technologies are needed to dramatically expand the ability to record and manipulate the activity of large numbers of neurons throughou