Project Summary/Abstract
The objective of “Brain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework (BCI-
DEF)” is to use structured vignettes, video-supported interviews, and a deliberative democracy approach to
assess and analyze diverse, critical stakeholder perspective
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleBCI-DEF: Brain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework
Investigator
Karen G Hirsch, Holly K Tabor
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
TitleBehavioral feedback and rewards for improving functional brain mapping in presurgical pediatric patients
Investigator
Ken Bruener, Damien A Fair, Jarod Roland
Institute
turing medical technologies inc
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract/Summary
The objective of this psychological technology SBIR/STTR Fast-Track proposal is to provide an innovative
gamified biofeedback solution (software-only) to improve the effectiveness of functional Magnetic Resonance
Imaging (fMRI) for pediatric pre-neurosurgical planning.
TitleBidirectional circuits of locus ceruleus and motor cortex neurons
Investigator
Gordon M Shepherd
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Primary motor cortex (M1) and the locus ceruleus (LC) both contribute in essential ways to the generation of
purposive movements – with M1 and its pyramidal tract (PT) neurons involved in action planning and execution,
the and LC and its noradrenergic axonal projections involved in a
TitleBiophysical and Neural Basis of Focused Ultrasound Stimulation
Investigator
Charles F Caskey, Li Min Chen
Institute
vanderbilt university medical center
Fiscal Year
Funding Opportunities Number
Project Number
This proposal responds to BRAIN Initiative RFA-NS-20-006 and aims to elucidate the neural and biophysical mechanisms of noninvasive focused ultrasound (FUS) neuromodulation.
TitleBRAIN Initiative: Hierarchical Event Descriptors (HED): a system to characterize events in neurobehavioral data
Investigator
Scott Makeig, Kay A Robbins, Arnaud Delorme
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
This two-year project will advance, integrate, document, and promote the use of the Hierarchical
Event Descriptor (HED) system to describe events in human neuroimaging and behavioral data
from research experiments and other sources in sufficient detail to support comparative analysis
of human brain
TitleBRAIN Integrated Resource for Human Anatomy and Intracranial Neurophysiology
Investigator
Dominique Duncan, Nader Pouratian
Institute
ut southwestern medical center
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Intracranial recordings in patients undergoing neurosurgical interventions provide a unique opportunity to directly
access, study, and learn about both normal human brain function and neuropsychiatric disease.
TitleBridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons
Investigator
Anton Arkhipov, Marina E. Garrett
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons
The versatile and powerful functional properties of the brain are reflected in the neuronal activity patterns and
computations, and their evolution over time due to learning, homeostatic plasticity, and other processes.
TitleBroadening access with an Armamentarium Vector Core Powered by Inclusive Research Experiences
Investigator
Viviana Gradinaru, Timothy Francis Shay
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The AAV BRAIN Safe and Effective Neuromodulator and Sensor Utilization across Species (SENSUS, led by
Caltech) of the NIH BRAIN Initiative Armamentarium Project will develop, validate, and disseminate integrated
(capsid and genome) engineered adeno-associated virus (AAV) tools to mon
TitleBroadly Accessible Technologies for Single-cell Joint Analysis of Transcriptome and Epigenome
Investigator
Bing Ren
Institute
epigenome technologies, inc.
Fiscal Year
Funding Opportunities Number
Opportunity Number PA-20-265
Project Number
Histone modifications carry rich information of cellular memory and gene regulatory mechanisms.
TitleCAJAL: A computational framework for the combined morphometric, transcriptomic, and physiological analysis of cells
Investigator
Pablo Gonzalez Camara
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Morphology is an essential phenotype in the characterization of cells and their states. It reflects the progression
of functional cellular processes, such as morphogenesis, migration, or dendrite arborization, and can be
indicative of disease.
TitleCaring for BRAIN pioneers: Understanding and enhancing family and researcher support in neural device trials
Investigator
Sara Goering, Eran Klein
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project abstract
BRAIN pioneers are people who take on significant risk as participants in first-in-human or early
neurotechnology studies for the sake of helping to further science.
TitleCell type specific AAVs to study reward and cognition
Investigator
Leah Byrne, Andreas Robert Pfenning, Afonso C Silva, William Richard Stauffer
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Adeno-Associated Viruses (AAVs) are potent gene delivery vectors for neuroscience studies and gene therapy
applications.
TitleCell Type-specific Anterograde Circuit Mapping and Functional Control by Optimizing YFV-17D Transneuronal Systems
Investigator
Wei Xu
Institute
ut southwestern medical center
Fiscal Year
Funding Opportunities Number
Project Number
Cell Type-specific Anterograde Circuit Mapping and Functional Control by
Optimizing YFV-17D Transneuronal Systems
Summary
To elucidate the functional organization of brain circuitry we need to delineate neuronal
connectivity and control the activity of neurons with specific connectivity.
TitleCenter for Multiomic Human Brain Cell Atlas
Investigator
M Margarita Behrens, Joseph R Ecker, Bing Ren, Ting Wang, Xiangmin Xu
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Understanding cell identities and their spatial distributions throughout different regions of the human brain is a
fundamental step when trying to integrate physiological, behavioral, neurochemical and molecular data.
TitleCircuit dynamics of structuring episodic memories in humans
Investigator
Jie Zheng
Institute
boston children's hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project summary
Our lives unfold over time, weaving rich, dynamic, and multisensory information into a continuous experience.
However, we remember this as a series of discrete events. For example, the memory of a two-hour movie
consists of a few memorable moments tied to the main story.
TitleCircuits for spontaneous behavior and phototaxis in a simple model chordate
Investigator
William Smith
Institute
university of california santa barbara
Fiscal Year
Funding Opportunities Number
Project Number
This proposal will investigate neural circuits driving negative phototaxis in an emerging model for neural circuit
analysis: larvae of the primitive chordate Ciona. Ciona larvae have a number of features that make them
ideally suited for this project.
TitleClosed-Loop Systems for Large Scale Spatiotemporal Imaging and Actuation of Neural Activity in Freely Behaving Animals
Investigator
Daniel Aharoni, Hugh T Blair, Peyman Golshani
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A major challenge in neuroscience is to uncover how defined neural circuits in the brain encode, store, modify, and retrieve information. Adding to this challenge is the fact that neural function does not operate in isolation but rather within living, behaving animals.
TitleCommercialization of integrated electrode-electronics system for large scale, long-lasting electrophysiology
Investigator
Loren M Frank, Mattias Peter Karlsson, Chong Xie, Jan Zimmermann
Institute
spikegadgets, llc
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Examining how behavior arises from the complex interconnected activity of the brain is a
cornerstone of neuroscience research. A recent technological advance in neurotechnology is
enabling studies where the parallel activity of thousands of neurons can be studied in rodent
brains.
TitleComprehensive single-cell atlas of the developing mouse brain
Investigator
Paola Arlotta, Tomasz Nowakowski, Hongkui Zeng
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The developing mouse brain is a foundational experimental model for investigation of the origins of cell types in
the mammalian brain.
TitleComputational dynamics in neural populations of freely foraging vs. restrained monkeys
Investigator
Dora Angelaki
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
Summary
This proposal will investigate the neural dynamics underlying three-dimensional foraging behavior, with three
overarching goals. The first is to evaluate the neural computations of foraging in dynamic environments in
naturalistic settings.