PROJECT SUMMARY
Over the last century, extracellular recording technologies have progressed from handmade needle electrodes
and vacuum tube amplifiers to microfabricated devices containing hundreds of recording sites and on-chip
digitization circuits.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleONIX: A Neural Acquisition System for Unencumbered, Closed-Loop Recordings in Small, Freely Moving Animals
Investigator
Jonathan Newman
Institute
open ephys, inc
Fiscal Year
Funding Opportunities Number
Project Number
TitleOpen-source miniaturized two-photon microscopes for large field-of-view and volumetric imaging
Investigator
Daniel Aharoni, Hugh T Blair, Anne Kathryn Churchland, Peyman Golshani, Alcino J. Silva, Alipasha Vaziri
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Abstract:
Single-photon (1P) epifluorescence miniaturized microscopy coupled with genetically encoded calcium sensors
has allowed investigators to record the activity of large populations of identified neurons over days to weeks in
freely behaving animals, answering fundamental questions in neurosci
TitleOptical neural motes to enable high density recording through intact dura in a nonhuman primate
Investigator
David Blaauw, Cynthia Anne Chestek
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
IR Powered and Hermetically-Sealed Single-Unit Neural Recording Wireless
Motes for Large Scale Implantation Into Nonhuman Primate Cortex
In this research agenda, we propose the ReMote which is a wireless neural recording probe that utilizes
near-infrared (NIR) light for
TitleOptical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation
Investigator
Xue Han
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation Deep brain stimulation (DBS) directly stimulates brain tissue via implanted electrodes.
TitleOptimization of Calcium and RNA multiplexed activity imaging for highly parallelized evaluation of cell type functions in deep-brain structures
Investigator
Meng Cui, Scott M Sternson
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A central goal of neuroscience is to understand animal behavior in the context of the information processing properties of neuron ensembles.
TitleOptimization of Flexible Neural Probe Arrays for Multi-Region Recordings in Rodents and Nonhuman Primates
Investigator
Ellis Meng, Dong Song
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
A core goal of the BRAIN Initiative is to link neural activity to behavior which requires technology to acquire high-quality recordings of dynamic neural activity from different brain regions over time.
TitleOptimization, application, and dissemination of imaging modules for high-speed mesoscopic volumetric recording of neuroactivity in scattering brains
Investigator
Alipasha Vaziri
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
A number of recent observations suggest that complex brain functions in the mammalian brain emerge from highly parallel computation in which information about sensory inputs, internal states, and behavioral parameters are mapped onto highly distributed brain-wide neuronal
TitleOrganic Closed-loop Electrochemical Array for Neurodevelopment (OCEAN)
Investigator
Dion Khodagholy
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
A major obstacle to understanding how the dynamic activity of brain circuits permits the emergence of cortical function is the insufficient capability to acquire and manipulate this activity across the course of brain maturation.
TitlePinpointing the Cerebellum's Contribution to Social Reward Processing
Investigator
Haroon Skander Popal
Institute
temple univ of the commonwealth
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The cerebellum has long been thought to solely process motor information. Yet, there is a growing literature
that points to a role of the cerebellum in processes across multiple domains.
TitlePREFRONTAL CIRCUITS OF WORKING MEMORY
Investigator
Christos Constantinidis, Boris V Zemelman
Institute
vanderbilt university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Working memory, the ability to maintain and manipulate in formation in memory over a period of seconds, is a
critical component of higher cognitive functions.
TitleProbing Neural Circuits of Zebrafish Sleep with Electrophysiology and Calcium Imaging
Investigator
David Aaron Prober, Thai V. Truong
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The zebrafish has emerged as a useful model system to discover and characterize genetic and neuronal circuits
that regulate vertebrate sleep.
TitleProtein ticker-tapes for brain-wide neural recordings
Investigator
Adam Ezra Cohen
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Protein ticker-tapes for brain-wide neural recordings
Behavior emerges from the interacting activity of widely distributed ensembles of neurons; but all existing tools
for measuring brain activity sample only a small subset of these dynamics.
TitleRapid brain-wide optogenetic screening with a noninvasive, dynamically programmable in vivo light source
Investigator
Kim Butts-Pauly, Xiaoke Chen, Guosong Hong
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Optogenetics provides a precise deconstruction of neural circuits by optically manipulating the activity of opsin-expressing neurons with fast temporal responses and neuron-type specificity.
TitleReal Time NEURON Simulation for Experimental Applications
Investigator
Mark W Nowak
Institute
cytocybernetics, inc.
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this proposal is to combine the power of the NEURON mathematical modeling software with the Cybercyte “plug and play” dynamic clamp system.
TitleReal-time mapping and adaptive testing for neural population hypotheses
Investigator
John Pearson
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Recent advances in neural recording technologies have made it possible to study increasingly large and di-
verse subsets of neurons, producing a growing interest in the collective computational properties of neural pop-
ulations.
TitleRevealing the mechanisms of primate face recognition with synthetic stimulus sets optimized to compare computational models
Investigator
Winrich Freiwald, Nikolaus Kriegeskorte
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Neuroscience is entering a new era, where large-scale neural network models can be tested with unprecedent-
edly rich measurements of neural activity.
TitleRibo-STAMPEDE: novel tools for molecular profiling of brain cell types
Investigator
Giordano Lippi, Eugene Wei-Ming Yeo
Institute
scripps research institute, the
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
A detailed and comprehensive census of central nervous system (CNS) cell types and states is essential to our
understanding of the neural substrates of cognition and behavior.
TitleRobot assisted brain-wide neural recordings and comprehensive behavioral monitoring in freely behaving mice
Investigator
Timothy J Ebner, Suhasa B Kodandaramaiah
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
The brain processes sensory inputs and contextualizes this information with internal brain states, generating the signals that drive motor and cognitive behaviors. The underlying computations are distributed across several anatomically and functionally distinct brain regions.
TitleRole of Endocannabinoid System in Seizure Sensitivity in Eclampsia
Investigator
Maria Jones-Muhammad
Institute
university of mississippi med ctr
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Preeclampsia, a hypertensive disorder of pregnancy, can advance to eclampsia, when the mother
displays novel seizures. The mechanisms that cause some preeclampsia patients to advance to
eclampsia are unknown.
TitleRole of neuronal ensembles in cortical plasticity during learning and development
Investigator
Alejandro Akrouh
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The brain undergoes extensive synaptic plasticity and circuit refinement during development. Similar
changes recur throughout life during learning in a more narrowly constrained manner.