Abstract The hippocampus has a well-established role in the initial formation and storage of memory. However, little is understood about brain mechanisms that support the re-organization and transfer of memories into longer-term cortical storage.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleBrain dynamics underlying long-term memory consolidation
Investigator
Priya Rajasethupathy
Institute
rockefeller university
Fiscal Year
Funding Opportunities Number
Project Number
TitleBrain-wide mapping of neuronal inhibition by novel inverse activity markers
Investigator
Li Ye
Institute
scripps research institute, the
Fiscal Year
Funding Opportunities Number
Project Number
Abstract This project aims to develop the first Inverse Activity Marker (IAM) for detecting neuronal inhibition (broadly defined as the decrease of neuronal activities).
TitleCell type-specific mechanisms of history-dependent perceptual biases in sensory cortex
Investigator
Deepa L Ramamurthy
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Sensory representations are influenced by an animal’s external context, internal state, past experiences, expectations, and future goals.
TitleCenter for Advanced Muscle BioElectronics (CAMBER)
Investigator
Muhannad Bakir, Samuel Sober
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
A central goal of neuroscience is to discover how neural circuits control the body’s muscles to produce behavior.
TitleCharacterizing Lower Extremity Neurophysiological Responses to Sensory Augmentation after Stroke
Investigator
Jasmine Jamilah Cash
Institute
medical university of south carolina
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT After a stroke, walking ability can be compromised, which can lead to reduced quality of life and decreased ability to perform activities of daily living.
TitleCharacterizing odor motion detection in flies
Investigator
Damon Alistair Clark, Thierry Emonet
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Many animals rely on their ability to navigate to the source of airborne odor plumes for survival. Studies dating back a century have shown that insects combine mechanosensory and olfactory cues to navigate, surging upwind when detecting odor but go crosswind or downwind when losing the signal.
TitleCircuit architecture and dynamics of the insular cortex underlying motivational behaviors
Investigator
Tianyi Mao, Haining Zhong
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The insular cortex (IC) is a multimodal hub that integrates interoceptive and exteroceptive information to control diverse aspects of animal behaviors related to cognition, emotion, and motivation.
TitleCircuit mechanisms of arbitration between distinct reinforcement learning systems
Investigator
Margaret Louise Demaegd
Institute
new york university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Animals can exhibit goal-directed behaviors in novel environments, despite limited experience with them. How does the brain make and use inferences about the underlying statistics and generative structure of environments to guide behavior?
TitleCircuit-specific, chemogenetic neuromodulation in nonhuman primates.
Investigator
Serge E Przedborski, Charles E Schroeder
Institute
nathan s. kline institute for psych res
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT ‒ UG3/UH3 Deep Brain Stimulation (DBS), applied to areas like the subthalamic nucleus (STN), is a standard treatment for Parkinson Disease (PD), however, DBS has inherent surgical risks as well as potential for infections and adverse side effects.
TitleCognitive and Neural Strategies for Latent Feature Inference
Investigator
Tahra Eissa
Institute
university of colorado
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY The world around us has a statistical structure that we can use to improve our choices. Learning the underlying structure by identifying key features, such as the rate of change, is useful for adapting and optimizing our decision-making strategies.
TitleCommercial translation of high-density carbon fiber electrode arrays for multi-modal analysis of neural microcircuits
Investigator
Rajmohan Bhandari, Cynthia Anne Chestek, Daniel Powell, Florian Solzbacher
Institute
blackrock microsystems
Fiscal Year
Funding Opportunities Number
Project Number
The ability to measure and manipulate local brain circuit activity in living, behaving animals is essential to understanding the complexities of brain function and dysfunction.
TitleCortical assembly formation through excitatory/inhibitory circuit plasticity
Investigator
Brent D. Doiron, Anne-Marie Michelle Oswald
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
Cortical assembly formation through excitatory/inhibitory circuit plasticity. Project Summary Throughout the brain, sensory information is thought to be represented by the joint activity of neurons that form functionally connected assemblies.
TitleCortical circuit dynamics underlying multisensory decision making
Investigator
Christopher R Fetsch
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary To navigate and guide locomotion in a complex 3D environment, humans and animals must make countless judgments of their direction of self-motion, or heading.
TitleDeconstructing the sertonin system in the mouse brain
Investigator
Liqun Luo, Scott Warren Linderman
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY Serotonin is an evolutionarily conserved neurotransmitter that modulates the activity of excitatory and inhibitory neurons throughout the entire mammalian brain and is thus essential for diverse aspects of physiology and behavior.
TitleDeveloping novel neural network tools for accurate and interpretable dynamical modeling of neural circuits
Investigator
Christopher Versteeg
Institute
emory university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract In recent years, the number of neurons that we can record simultaneously has seen an exponential increase, presenting a daunting challenge: how do we analyze these complex and high-dimensional datasets to gain insight into how neural circuits perform computation?
TitleDeveloping Novel Trans-Synaptic Viral Vectors for Orthogonal or Rapid Circuit Tracing
Investigator
Euiseok J Kim
Institute
university of california santa cruz
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary To determine the anatomical basis of complex neural behavior, it is critical to have the ability to trace more than one circuit simultaneously in the same animal.
TitleDevelopment and In Vivo Validation of a Theoretical Framework and Practical Methods to Improve Safety and Efficacy of Neuromodulation Electrodes
Investigator
Kip A Ludwig
Institute
university of wisconsin-madison
Fiscal Year
Funding Opportunities Number
Project Number
Despite widespread clinical use, the theoretical framework by which to understand safety of electrical stimulation through implanted electrodes is surprisingly limited.
TitleDissecting modular and redundant organization of cortical circuits
Investigator
Shaul Druckmann, Nuo Li
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
Abstract In many cognitive processes, information is processed in a parallel manner across many brain regions.
TitleDissemination of the Human Neocortical Neurosolver (HNN) software for circuit level interpretation of human MEG/EEG
Investigator
Stephanie Ruggiano Jones
Institute
brown university
Fiscal Year
Funding Opportunities Number
Project Number
HNN U24 DISSEMINATION PROJECT SUMMARY The Human Neocortical Neurosolver (HNN) neural modeling tool was developed with BRAIN Initiative funding (R01EB022889: 09/2016–06/2020) to meet the Initiative’s goal to “develop innovative technologies to understand brain circuits and ensembles of circuits th
TitleDistinct contributions of converging neural pathways to auditory learning
Investigator
Santiago Jaramillo, James Murray
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT Effective interpretation of sensory stimuli relies on the ability to discriminate stimulus features and link them to appropriate behavioral responses depending on past experience.