PROJECT SUMMARY/ABSTRACT
Intracranial recordings in patients undergoing neurosurgical interventions provide a unique opportunity to directly
access, study, and learn about both normal human brain function and neuropsychiatric disease.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleBRAIN Integrated Resource for Human Anatomy and Intracranial Neurophysiology
Investigator
Dominique Duncan, Nader Pouratian
Institute
ut southwestern medical center
Fiscal Year
Funding Opportunities Number
Project Number
TitleBridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons
Investigator
Anton Arkhipov, Marina E. Garrett
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons
The versatile and powerful functional properties of the brain are reflected in the neuronal activity patterns and
computations, and their evolution over time due to learning, homeostatic plasticity, and other processes.
TitleBroadening access with an Armamentarium Vector Core Powered by Inclusive Research Experiences
Investigator
Viviana Gradinaru, Timothy Francis Shay
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The AAV BRAIN Safe and Effective Neuromodulator and Sensor Utilization across Species (SENSUS, led by
Caltech) of the NIH BRAIN Initiative Armamentarium Project will develop, validate, and disseminate integrated
(capsid and genome) engineered adeno-associated virus (AAV) tools to mon
TitleCAJAL: A computational framework for the combined morphometric, transcriptomic, and physiological analysis of cells
Investigator
Pablo Gonzalez Camara
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Morphology is an essential phenotype in the characterization of cells and their states. It reflects the progression
of functional cellular processes, such as morphogenesis, migration, or dendrite arborization, and can be
indicative of disease.
TitleCaring for BRAIN pioneers: Understanding and enhancing family and researcher support in neural device trials
Investigator
Sara Goering, Eran Klein
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project abstract
BRAIN pioneers are people who take on significant risk as participants in first-in-human or early
neurotechnology studies for the sake of helping to further science.
TitleCell type specific AAVs to study reward and cognition
Investigator
Leah Byrne, Andreas Robert Pfenning, Afonso C Silva, William Richard Stauffer
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Adeno-Associated Viruses (AAVs) are potent gene delivery vectors for neuroscience studies and gene therapy
applications.
TitleCell Type-specific Anterograde Circuit Mapping and Functional Control by Optimizing YFV-17D Transneuronal Systems
Investigator
Wei Xu
Institute
ut southwestern medical center
Fiscal Year
Funding Opportunities Number
Project Number
Cell Type-specific Anterograde Circuit Mapping and Functional Control by
Optimizing YFV-17D Transneuronal Systems
Summary
To elucidate the functional organization of brain circuitry we need to delineate neuronal
connectivity and control the activity of neurons with specific connectivity.
TitleCenter for Multiomic Human Brain Cell Atlas
Investigator
M Margarita Behrens, Joseph R Ecker, Bing Ren, Ting Wang, Xiangmin Xu
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Understanding cell identities and their spatial distributions throughout different regions of the human brain is a
fundamental step when trying to integrate physiological, behavioral, neurochemical and molecular data.
TitleCircuit dynamics of structuring episodic memories in humans
Investigator
Jie Zheng
Institute
boston children's hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project summary
Our lives unfold over time, weaving rich, dynamic, and multisensory information into a continuous experience.
However, we remember this as a series of discrete events. For example, the memory of a two-hour movie
consists of a few memorable moments tied to the main story.
TitleComprehensive single-cell atlas of the developing mouse brain
Investigator
Paola Arlotta, Tomasz Nowakowski, Hongkui Zeng
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The developing mouse brain is a foundational experimental model for investigation of the origins of cell types in
the mammalian brain.
TitleDeciphering the genomic mechanisms underlying the physiology of human brain stimulation
Investigator
Genevieve Konopka, Bradley C Lega
Institute
ut southwestern medical center
Fiscal Year
Funding Opportunities Number
Project Number
The underlying mechanisms of brain stimulation in humans are poorly understood, especially at the level of gene expression.
TitleDeep and fast imaging using adaptive excitation sources
Investigator
Chris Xu
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Optical recordings of activity are critical to probe neural systems because they provide high-resolution,
non-invasive measurements, ranging from single neurons to entire populations in intact nervous systems, and
are readily combined with genetic methods to provide cell type-specific reco
TitleDefining the circuit, synaptic, and molecular mechanisms linking intracellular Ca2+ release to learning using subcellularly-targeted manipulations and imaging techniques in dendrites in vivo
Investigator
Justin O'hare
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Candidate Goals and Mission Relevance: The applicant’s broad, long-term objective is to investigate how high-
(circuit/behavioral) and low- (subcellular/molecular) level organizational principles of the brain cooperate to drive
learning.
TitleDevelopment and Validation of a Genetically Encoded Method to Trace and Manipulate Neuronal Circuits in Zebrafish
Investigator
Carlos Lois, David Aaron Prober
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Identifying how neurons are connected to each other in the brain is an important and necessary step towards
understanding how brain activity gives rise to behavior, and how it is perturbed by disease.
TitleDevelopment of kinase biosensors for multiplex neuronal imaging of signaling pathways in behaving mice
Investigator
Richard L Huganir, Jin Zhang
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Cell signaling pathways in the brain are an essential part of a complex system regulating the activity and
coordination of neuronal networks.
TitleDissecting the role of cortico-basal ganglia circuit diversity in action learning from reinforcement
Investigator
Alice Mosberger
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
To learn novel actions through reinforcement, a fundamental mechanism of motor learning, the brain needs to
causally link previously performed movements to their resulting outcomes.
TitleDissection of Cell Type Specific Contributions to Motor Learning Circuits
Investigator
Lina Marcela Carmona
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Whether riding your bike down a narrow path or reaching for your favorite cookie in a small box, many of our
daily actions require skilled and accurate movements. However, to achieve proficiency, these motor skills must
first be learned through the process of motor learning.
TitleDissemination of FlyWire, A Whole-Brain Connectomics Resource
Investigator
Mala Murthy
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
This proposal will disseminate FlyWire, a Drosophila whole brain connectomics resource. We
used advances in AI to segment all neurons from a whole brain EM volume called FAFB.
TitleDissemination of MAPseq and BARseq for high-throughput brain mapping
Investigator
Anthony M Zador
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to disseminate MAPseq and BARseq to the broader neuroscience
community. These are novel methods developed in my laboratory based on high-throughput DNA
sequencing for determining neuronal circuitry.
TitleDistributed Neural Activity Patterns Underlying Practice-Based Learning
Investigator
Kimberly Reinhold
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
To survive, animals must learn appropriate associations between sensory cues and motor actions through a
process of trial and error.