PROJECT SUMMARY
The human basal ganglia (BG) are a collection of subcortical regions whose diverse, specialized cell types
influence motor control, emotional regulation, habit formation, and higher cognition.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleA cellular atlas of the primate and human basal ganglia
Investigator
Jason Daniel Buenrostro, Fei Chen, Gordon J Fishell, Evan Z Macosko
Institute
broad institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
TitleA community-driven development of the brain imaging data standard (BIDS) to describe macroscopic brain connections
Investigator
Franco Pestilli
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The Brain Imaging Data Structure (BIDS) is a BRAIN initiative (R24 MH114705)
community-driven standard meant to maximize neuroimaging data sharing, and facilitate analysis tool
development.
TitleA Computational Framework for Distributed Registration of Massive Neuroscience Images
Investigator
Matthew Mccormick
Institute
kitware, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Neuroscience stands at the precipice of a new depth of understanding about how the brain works thanks to recent
advances in imaging data acquisition technologies such as light-sheet fluorescence microscopy (LSFM).
TitleA harmonized vendor-agnostic environment for multi-site functional MRI studies
Investigator
Jon-Fredrik Nielsen, Maxim Zaitsev
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Since its invention in the early 90s, functional magnetic resonance imaging (fMRI) has revolutionized our un-
derstanding of the human brain. Functional MRI may be used to observe brain function during a specific motor
or cognitive task, or at “rest” (resting-state fMRI).
TitleA Tool for Synapse-level Circuit Analysis of Human Cerebral Cortex Specimens.
Investigator
Jeff W Lichtman
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The goal of this work is to facilitate synaptic level analysis of neurons and their interconnecting microcircuits in
neurosurgical cerebral cortex biopsies from human patients.
TitleA web-based framework for multi-modal visualization and annotation of neuroanatomical data
Investigator
David Kleinfeld, Samuel Sheng-Hung Wang
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Modern experimental approaches allow researchers to collect a variety of whole-brain data from the same animal
via different anatomical labels, including tracers, genetic markers, and fiducial marks from recording electrodes.
Unfortunately, viewing and analysis methods have
TitleAcute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy
Investigator
Nuri Firat Ince
Institute
university of houston
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
High frequency oscillations (HFOs) of intracranial EEG (iEEG) have the potential to identify the surgical resection
area/seizure onset zone (SOZ) in patients with drug resistant epilepsy.
TitleAdvancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format
Investigator
Anton Arkhipov, Emad Tajkhorshid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format
One of the major goals of the BRAIN Initiative is to distill complex, multi-modal data into predictive frameworks
via theory/modeling.
TitleAdvancing Standardization of Neurophysiology Data Through Dissemination of NWB
Investigator
Benjamin K Dichter, Oliver Ruebel
Institute
university of calif-lawrenc berkeley lab
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Lack of standards for neurophysiology data and related metadata is the single greatest impediment to fully
extracting return on investment from neurophysiology experiments.
TitleAn Alignment Framework For Mapping Brain Dynamics and Substrates of Human Cognition Across Species
Investigator
Ting Xu
Institute
child mind institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The non-human primate (NHP) model is critical to the advancement of translational neuroscience, as it allows
researchers to link observations regarding macroscale brain dynamics and cognition in the human to underlying
meso- and microscale phenomena that cannot be fully investigated in huma
TitleAn integrated single-neuronal, population-, local network- and stimulation-based prefrontal investigation of human social cognition
Investigator
Ziv Williams
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
An integrated single-neuronal, population-, local network- and stimulation-based
prefrontal investigation of human social cognition
This proposal aims to undertake a comprehensive single-cellular, population-, local circuit- and stimulation-
based evaluation of the role that the dorsal prefrontal co
TitleAnticipating ethical challenges and disparities in the dissemination of novel neurotechnologies
Investigator
Winston Chiong, Daniel P. Dohan
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
A central goal for the second half of the BRAIN Initiative is to develop new circuit-based treatments for
brain diseases.
TitleBig-Data Electron-microscopy for Novel Community Hypotheses: Measuring And Retrieving Knowledge (BENCHMARK)
Investigator
William R Gray Roncal
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
In an effort to better understand structural organization and anatomy of nervous systems at
unprecedented spatial resolution, recent efforts, including BRAIN Initiative funded projects, have
collected increasingly larger datasets using Electron Microscopy (EM) and X-Ray
Microtomograp
TitleBRAIN Initiative: Assessing development of event-related cortical network dynamics
Investigator
Scott Makeig, Michael Peter Milham, Arnaud Delorme
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The Child Mind Institute’s Healthy Brain Network (HBN) is an ongoing initiative focused on creating and
sharing a biobank of brain and behavioral data now being collected from 10,000 New York City area children
and adolescents (ages 5-21).
TitleBRAIN Viral Vector Services and Distribution Core
Investigator
Kimberly Ritola
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
The BRAIN Viral Vector Service and Distribution Core will serve as a resource for the maintenance,
propagation, and distribution of viral vectors that are used by neuroscientists for neural circuit
identification and manipulation, as well as for preclinical translational studies.
TitleBRAINShare: Sharing Data in BRAIN Initiative Studies
Investigator
Amy L Mcguire, Sameer Anil Sheth
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Data sharing is essential to promote equity and maximize the impact of the significant investment in the BRAIN
Initiative.
TitleCell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
Investigator
Anton Arkhipov, Li-Huei Tsai
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
Patterned sensory stimulation (PSS) is a non-invasive technique for manipulating brain activity and states,
typically employing periodic light flicker or auditory tones presented at regular intervals.
TitleCellular and Neural Network Mechanism of Transcranial Electric Stimulation
Investigator
Dominique M Durand
Institute
case western reserve university
Fiscal Year
Funding Opportunities Number
Project Number
Unveiling mechanisms of neural stimulation technologies is an important goal of the Brain Initiative (RFA-NS-20-006).
TitleCellular Mechanisms of Transcranial Magnetic Stimulation in Cerebellar Cortex
Investigator
Padmavathi Sundaram Patel
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Abstract: Our goal is to develop a cellular level understanding of how transcranial magnetic stimulation (TMS)
may activate neurons in the human cerebellum (Cb) using (i) electrophysiological measurements in an in vitro
turtle Cb, (ii) computational modeling of the induced electric (E) fields in the
TitleCharacterization of in vivo neuronal and inter-neuronal responses to transcranial focused ultrasound
Investigator
Bin He
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
Non-invasive neuromodulation approaches have been developed to enable the modulation of neural tissue without necessitating invasive surgical procedures.