Motivation and Objectives Why are ion channels localized in subcellular dendritic compartments and is there a tight coupling of the observed localization with neuron function?
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleCRCNS: Understanding Single-Neuron Computation Using Nonlinear Model Optimization
Investigator
Fabrizio Gabbiani, Matthias Heinkenschloss
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
TitleDefining the circuit, synaptic, and molecular mechanisms linking intracellular Ca2+ release to learning using subcellularly-targeted manipulations and imaging techniques in dendrites in vivo
Investigator
Justin O'hare
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Candidate Goals and Mission Relevance: The applicant’s broad, long-term objective is to investigate how high-
(circuit/behavioral) and low- (subcellular/molecular) level organizational principles of the brain cooperate to drive
learning.
TitleDissecting circuit and cellular mechanisms for limb motor control
Investigator
John Tuthill
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Motor neurons connect to muscles and comprise the major output of the nervous system. Patterns of
neural activity in motor neurons cause temporally precise muscle contractions, producing coordinated
and flexible behavior.
TitleDissecting the role of cortico-basal ganglia circuit diversity in action learning from reinforcement
Investigator
Alice Mosberger
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
To learn novel actions through reinforcement, a fundamental mechanism of motor learning, the brain needs to
causally link previously performed movements to their resulting outcomes.
TitleDissection of Cell Type Specific Contributions to Motor Learning Circuits
Investigator
Lina Marcela Carmona
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Whether riding your bike down a narrow path or reaching for your favorite cookie in a small box, many of our
daily actions require skilled and accurate movements. However, to achieve proficiency, these motor skills must
first be learned through the process of motor learning.
TitleDissection of spatiotemporal activity from large-scale, multi-modal, multi-resolution hippocampal-neocortical recordings.
Investigator
Gyorgy Buzsaki, Zhe Sage Chen
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ ABSTRACT
Advances in neurotechnologies are producing large and complex datasets at unprecedented rate.
TitleDissemination of FlyWire, A Whole-Brain Connectomics Resource
Investigator
Mala Murthy
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
This proposal will disseminate FlyWire, a Drosophila whole brain connectomics resource. We
used advances in AI to segment all neurons from a whole brain EM volume called FAFB.
TitleDissemination of MAPseq and BARseq for high-throughput brain mapping
Investigator
Anthony M Zador
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to disseminate MAPseq and BARseq to the broader neuroscience
community. These are novel methods developed in my laboratory based on high-throughput DNA
sequencing for determining neuronal circuitry.
TitleDistributed Neural Activity Patterns Underlying Practice-Based Learning
Investigator
Kimberly Reinhold
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
To survive, animals must learn appropriate associations between sensory cues and motor actions through a
process of trial and error.
TitleEarly-Life Stress Drives Increased Heroin Vulnerability: Role of D3 Receptors
Investigator
Brianna Elyse George
Institute
wake forest university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Stress and addiction are intricately linked neural processes. Acute stress can serve as a stimulus for relapse to
compulsive drug seeking following abstinence, and chronic stress can induce escalated drug intake to multiple
classes of drugs.
TitleElucidating Principles of Sensorimotor Control using Deep Learning
Investigator
Shreya Saxena
Institute
university of florida
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
How do distributed neural circuits drive purposeful movements from the complex musculoskeletal system?
TitleEmpirical Power Analysis Tool for fMRI
Investigator
Stephanie Noble
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Functional magnetic resonance imaging (fMRI) research has transformed our understanding of human brain
function and disease and is flourishing under unprecedented international funding, including dedicated support
from the BRAIN Initiative.
TitleEnabling precise cell-type-specific dissection of orientation and memory circuits in retrosplenial cortex
Investigator
Omar Jamil Ahmed
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
In humans, damage to a brain region called the retrosplenial cortex leads to pronounced spatial disorientation
and severe retrograde and anterograde memory deficits.
TitleFeedback and feedforward gating of sensory signaling through timing in the thalamocortical loop
Investigator
Garrett B. Stanley
Institute
georgia institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Feedback and feedforward gating of sensory signaling through timing in the thalamocortical loop
Nearly all sensory experience begins in the periphery, generating sensory signals travelling through the thalamus
before reaching neocortex.
TitleFostering Ethical Neurotechnology Academia-Industry Partnerships: A Stakeholder Engagement and Toolkit Development Project
Investigator
Tristan Mcintosh
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Neurotechnologies used to treat brain disorders and diseases can drastically change brain function and behavior,
monitor brain activity, and collect and transmit personal health data.
TitleFrom synapses to neural representations: The role of neuromodulatory circuits in shaping contextual memories in the hippocampus
Investigator
Mark E J Sheffield
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: Memory enables animals to acquire, store, and recall knowledge of the world
through experience and use this knowledge to maximize reward and avoid danger.
TitleFunctional connectivity of a brain-scale neural circuit for motion perception
Investigator
Eva Aimable Naumann
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The transformation of visual cues into appropriate behavior requires the collaboration of diverse neurons across
distant brain areas.
TitleFunctional dissection of cerebellar output circuits that orchestrate limb motor control
Investigator
Eiman Azim, Albert Chen
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The cerebellum is essential for coordinating motor behavior through rapid adjustments of ongoing movements.
To refine movement, the cerebellum processes motor and sensory information, and transmits output that
ultimately modulates motor neuron activity to ensure successful execution.
TitleFunctional interrogation of the mouse somatosensory thalamic interneuron in sensory perception and rhythmic states
Investigator
Jane Yi
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT/SUMMARY
The mouse somatosensory thalamus participates in fundamental processes including sensory processing, sleep
and pathological rhythmic behaviors like seizure. Local thalamic interneurons have been considerably
overlooked due to their sparsity in the total neuronal population.
TitleFunctional Mapping of the Suprachiasmatic Nucleus
Investigator
Karen Jill Tonsfeldt
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
This proposal aims to delineate the electrical and molecular diversity of the suprachiasmatic nucleus (SCN) and
provide new evidence for receptor-expressing subtypes of SCN neurons using novel nanowire arrays that allow
single cell recording at 1024 contacts simultaneously.