Cell Type-specific Anterograde Circuit Mapping and Functional Control by
Optimizing YFV-17D Transneuronal Systems
Summary
To elucidate the functional organization of brain circuitry we need to delineate neuronal
connectivity and control the activity of neurons with specific connectivity.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleCell Type-specific Anterograde Circuit Mapping and Functional Control by Optimizing YFV-17D Transneuronal Systems
Investigator
Wei Xu
Institute
ut southwestern medical center
Fiscal Year
Funding Opportunities Number
Project Number
TitleCircuit dynamics of structuring episodic memories in humans
Investigator
Jie Zheng
Institute
boston children's hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project summary
Our lives unfold over time, weaving rich, dynamic, and multisensory information into a continuous experience.
However, we remember this as a series of discrete events. For example, the memory of a two-hour movie
consists of a few memorable moments tied to the main story.
TitleClosed-Loop Systems for Large Scale Spatiotemporal Imaging and Actuation of Neural Activity in Freely Behaving Animals
Investigator
Daniel Aharoni, Hugh T Blair, Peyman Golshani
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A major challenge in neuroscience is to uncover how defined neural circuits in the brain encode, store, modify, and retrieve information. Adding to this challenge is the fact that neural function does not operate in isolation but rather within living, behaving animals.
TitleCommercialization of integrated electrode-electronics system for large scale, long-lasting electrophysiology
Investigator
Loren M Frank, Mattias Peter Karlsson, Chong Xie, Jan Zimmermann
Institute
spikegadgets, llc
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Examining how behavior arises from the complex interconnected activity of the brain is a
cornerstone of neuroscience research. A recent technological advance in neurotechnology is
enabling studies where the parallel activity of thousands of neurons can be studied in rodent
brains.
TitleDataJoint SciOps: A Managed Service for Neuroscience Data Workflows
Investigator
Dimitri Yatsenko
Institute
vathes inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project summary
This SBIR proposal aims to address current challenges in data-driven neuroscience by implementing DataJoint
SciOps: a commercial service to help research labs implement computational workflows for data-intensive science
experiments.
TitleDeciphering the genomic mechanisms underlying the physiology of human brain stimulation
Investigator
Genevieve Konopka, Bradley C Lega
Institute
ut southwestern medical center
Fiscal Year
Funding Opportunities Number
Project Number
The underlying mechanisms of brain stimulation in humans are poorly understood, especially at the level of gene expression.
TitleDeep Analysis of Brain Chemistry at Enhanced Spatial and Temporal Resolution using Microscale Sampling and Analysis
Investigator
Robert T Kennedy
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
The objective of this project is to develop new bioanalytical methods for exploring brain chemistry dynamics in vivo. Monitoring the concentration dynamics of neurochemicals in vivo is vital for studying brain function, diseases, and treatments.
TitleDeep and fast imaging using adaptive excitation sources
Investigator
Chris Xu
Institute
cornell university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Optical recordings of activity are critical to probe neural systems because they provide high-resolution,
non-invasive measurements, ranging from single neurons to entire populations in intact nervous systems, and
are readily combined with genetic methods to provide cell type-specific reco
TitleDefining the circuit, synaptic, and molecular mechanisms linking intracellular Ca2+ release to learning using subcellularly-targeted manipulations and imaging techniques in dendrites in vivo
Investigator
Justin O'hare
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Candidate Goals and Mission Relevance: The applicant’s broad, long-term objective is to investigate how high-
(circuit/behavioral) and low- (subcellular/molecular) level organizational principles of the brain cooperate to drive
learning.
TitleDevelopment and Testing of LUCID: A Therapeutic Device for Brain Injury Following Infant Cardiac Arrest
Investigator
Wiley Thomas Waddell, Maik Huettemann, Thomas Hudson Sanderson
Institute
mitovation, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Cardiac arrest in infants is a medical emergency requiring rapid resuscitation to restore circulation. However, resuscitation often results in significant brain injury, caused by ischemia/reperfusion injury.
TitleDevelopment and Validation of a Genetically Encoded Method to Trace and Manipulate Neuronal Circuits in Zebrafish
Investigator
Carlos Lois, David Aaron Prober
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Identifying how neurons are connected to each other in the brain is an important and necessary step towards
understanding how brain activity gives rise to behavior, and how it is perturbed by disease.
TitleDevelopment of a Miniaturized Wearable Ultrasonic Beam-forming Device for Localized Targeting of Brain Regions in Freely-moving Experimental Subjects
Investigator
Kevin A Snook
Institute
actuated medical, inc.
Fiscal Year
Funding Opportunities Number
Project Number
This Phase I SBIR will further develop, validate, and initiate commercialization of the miniature ultrasound
beamforming array (MUBA) system for transcranial focused ultrasound (tFUS).
TitleDevelopment of a sample preparation protocol for brain ultrastructural analysis, immunolabeling, and neuronal tracing by light microscopy
Investigator
Ons M'saad
Institute
panluminate inc.
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
The brain is the most complex organ in the human body. Understanding its neural connections and molecular
anatomy requires imaging technology that is capable of mapping the 3D nanoscale distribution of specific
proteins in the context of brain ultrastructure.
TitleDevelopment of kinase biosensors for multiplex neuronal imaging of signaling pathways in behaving mice
Investigator
Richard L Huganir, Jin Zhang
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Cell signaling pathways in the brain are an essential part of a complex system regulating the activity and
coordination of neuronal networks.
TitleDevelopment of opioid and ketamine probes for in vivo photopharmacology
Investigator
Matthew Ryan Banghart, Conor M Liston
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Pharmacological probes are widely used to study the nervous system. Despite often exhibiting exquisite specificity for target receptors, due to diffusion, traditional small molecule drugs act slowly and with spatial imprecision.
TitleDissecting the role of cortico-basal ganglia circuit diversity in action learning from reinforcement
Investigator
Alice Mosberger
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
To learn novel actions through reinforcement, a fundamental mechanism of motor learning, the brain needs to
causally link previously performed movements to their resulting outcomes.
TitleDissection of Cell Type Specific Contributions to Motor Learning Circuits
Investigator
Lina Marcela Carmona
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract
Whether riding your bike down a narrow path or reaching for your favorite cookie in a small box, many of our
daily actions require skilled and accurate movements. However, to achieve proficiency, these motor skills must
first be learned through the process of motor learning.
TitleDissemination of FlyWire, A Whole-Brain Connectomics Resource
Investigator
Mala Murthy
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
This proposal will disseminate FlyWire, a Drosophila whole brain connectomics resource. We
used advances in AI to segment all neurons from a whole brain EM volume called FAFB.
TitleDissemination of MAPseq and BARseq for high-throughput brain mapping
Investigator
Anthony M Zador
Institute
cold spring harbor laboratory
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to disseminate MAPseq and BARseq to the broader neuroscience
community. These are novel methods developed in my laboratory based on high-throughput DNA
sequencing for determining neuronal circuitry.
TitleDistributed Neural Activity Patterns Underlying Practice-Based Learning
Investigator
Kimberly Reinhold
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY / ABSTRACT
To survive, animals must learn appropriate associations between sensory cues and motor actions through a
process of trial and error.