PROJECT SUMMARY
Stress and addiction are intricately linked neural processes. Acute stress can serve as a stimulus for relapse to
compulsive drug seeking following abstinence, and chronic stress can induce escalated drug intake to multiple
classes of drugs.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleEarly-Life Stress Drives Increased Heroin Vulnerability: Role of D3 Receptors
Investigator
Brianna Elyse George
Institute
wake forest university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
TitleEfficient Two-Photon Voltage Imaging of Neuronal Populations at Behavioral Timescales
Investigator
Jerry L Chen, Vincent A Pieribone, Michelle Yen-Ling Sander
Institute
boston university (charles river campus)
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Understanding how information is processed in the mammalian neocortex has been a longstanding
question in neuroscience. While the action potential is the fundamental bit of information, how these
spikes encode representations and drive behavior remains unclear.
TitleEmpirical Power Analysis Tool for fMRI
Investigator
Stephanie Noble
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Functional magnetic resonance imaging (fMRI) research has transformed our understanding of human brain
function and disease and is flourishing under unprecedented international funding, including dedicated support
from the BRAIN Initiative.
TitleEngineering the Neuronal Response to Electrical Microstimulation
Investigator
Mark E. Orazem, Kevin J. Otto
Institute
university of florida
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Our proposed efforts align directly with a goal of RFA-NS-18-019: optimization of transformative technologies for modulation in the nervous system.
TitleExploring the Parameter Space of High Frequency Magnetic Perturbation in Manipulating Neural Excitability and Plasticity.
Investigator
Ludovica Labruna
Institute
magnetic tides, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Non-invasive brain stimulation (NIBS) has attracted considerable interest in the cognitive neuroscience community, providing an important basic research tool to study brain function, with emerging clinical applications to enhance function in individuals with neurological disorders.
TitleFast Multichannel Magneto-thermal Genetics
Investigator
Jacob T. Robinson
Institute
rice university
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Precisely timed activation of genetically targeted cells is a powerful tool for studying neural circuits. Neuronal modulation (activating or inhibiting select neurons) allows us to investigate how neural activity causes changes in animal behavior.
TitleFostering Ethical Neurotechnology Academia-Industry Partnerships: A Stakeholder Engagement and Toolkit Development Project
Investigator
Tristan Mcintosh
Institute
washington university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Neurotechnologies used to treat brain disorders and diseases can drastically change brain function and behavior,
monitor brain activity, and collect and transmit personal health data.
TitleFunctional interrogation of the mouse somatosensory thalamic interneuron in sensory perception and rhythmic states
Investigator
Jane Yi
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT/SUMMARY
The mouse somatosensory thalamus participates in fundamental processes including sensory processing, sleep
and pathological rhythmic behaviors like seizure. Local thalamic interneurons have been considerably
overlooked due to their sparsity in the total neuronal population.
TitleFunctional Mapping of the Suprachiasmatic Nucleus
Investigator
Karen Jill Tonsfeldt
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
This proposal aims to delineate the electrical and molecular diversity of the suprachiasmatic nucleus (SCN) and
provide new evidence for receptor-expressing subtypes of SCN neurons using novel nanowire arrays that allow
single cell recording at 1024 contacts simultaneously.
TitleGene regulatory networks influencing neuron-microglia interactions in fetal brain development.
Investigator
Claudia Z Han
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The prenatal period is a sensitive and critical time for brain development characterized by waves of neurogenesis,
neuronal migration, and formation of neural networks.
TitleHigh-resolution bidirectional optical-acoustic mesoscopic neural interface for image-guided neuromodulation in behaving animals
Investigator
Robert E. Campbell, Daniel Razansky, Shy Shoham
Institute
new york university school of medicine
Fiscal Year
Funding Opportunities Number
Project Number
SUMMARY
Acoustic technologies such as optoacoustic (OA) imaging and ultrasound neuromodulation (USNM) are poised to revolutionize deep tissue, high-resolution, large-scale, in vivo imaging, and neurostimulation in mammalian organisms.
TitleHigh-throughput sequencing of synaptic partnerships and gene expression at single-cell resolution in vivo
Investigator
Arpiar B Saunders
Institute
oregon health & science university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Brain function depends on forming and maintaining synaptic connections between neurons of specific types,
yet systematic descriptions of cell-type connectivity and the molecules that instruct these relationships remain
challenging because we lack some necessary tools.
TitleHighly parallel long wavelength heterodyne diffuse correlation spectroscopy for brain functional imaging
Investigator
Stefan Alexandru Carp
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Non-invasive imaging of human brain function plays an important role in advancing neuroscience research and
understanding neurological diseases. This need has been met primarily by functional magnetic resonance
imaging (fMRI).
TitleHormonal regulation of sensory processing during parental care
Investigator
Kristina O. Smiley
Institute
university of massachusetts amherst
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Does the way we hear sounds change when we become parents?
TitleIdentifying prefrontal signatures of successful and dysfunctional attention
Investigator
Brielle Ferguson
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Attention is comprised of several component processes, including sustained attention, selective
attention, and attentional flexibility.
TitleImaging at the speed of spikes: An electro-optical multiphoton microscope
Investigator
Aaron Michael Kerlin
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Signals in the brain are transmitted and transformed on a millisecond timescale. The precise timing of activity can carry unique information, correlate perceptual decisions, and powerfully influence synaptic plasticity.
TitleImplementation and dissemination of cloud-based retrospective hemodynamic analysis tools to enhance HCP data interpretation
Investigator
Blaise Debonneval Frederick
Institute
mclean hospital
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Functional Magnetic Resonance Imaging data has been a mainstay of neuroscience research for more than two
decades, as it allows rapid, continuous, noninvasive monitoring of neuronal function.
TitleImproving the robustness of neuroimaging through exploitation of variability in processing pipelines
Investigator
Gregory Kiar, Michael Peter Milham
Institute
child mind institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Reproducible findings are essential to scientific advancement. Unfortunately, when fields lack consensus
standards for methods, or their implementations, reproducibility tends to be more of an ideal than a reality.
TitleIn situ Single-Cell Multi-Omic and Morphological Profiling in Mammalian Brains
Investigator
Chongyuan Luo
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Single-cell technologies have revolutionized the characterization of mammalian brains allowing unbiased census
of cell types and their transcriptomic and epigenomics signatures.
TitleIntegrated functional and structural analysis of an entire column in mouse primary visual cortex
Investigator
Reza Abbasi Asl
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Neurons in the visual cortex form an intricate connectivity structure and topographic arrangement. The
structural and morphological organization of the neurons is known to constrain its functional properties.