Tools for Gene Editing in Marmosets
SUMMARY
The goal of this proposal is to create an efficient new set of tools and techniques for the generation of
genetically modified marmosets suitable for use as models of brain physiology and function.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleTools for gene editing in marmosets
Investigator
Richard L Huganir, Christopher A Ross, James H. Segars, Xiaoqin Wang
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
TitleUnderstanding how cortex supports flexible sensory representations
Investigator
Katherine Charlotte Wood
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Learning is a fundamental function of the brain: sensory representations must be flexible to adjust to changes in
environmental demands and experience, thus allowing us to adapt to the world around us.
TitleVirtual observatory of the cortex: organelles, cells, circuits, and dynamics
Investigator
Forrest Christie Collman, Nuno Macarico Da Costa, R Clay Reid, Hyunjune Sebastian Seung
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
We propose to create VOrtex, a Virtual Observatory for the Cortex: Spanning the Scales of Organelles, Cells,
Circuits, and Dynamics.
TitleWearable RF-EEG Cap for closed loopTMS/fMRI/EEG Applications
Investigator
Lucia Isabel Navarro De Lara
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Functional MRI (fMRI) is the prevailing method for both basic research and clinical functional neuroimaging in
humans.
TitleA community-driven development of the brain imaging data standard (BIDS) to describe macroscopic brain connections
Investigator
Franco Pestilli
Institute
university of texas at austin
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The Brain Imaging Data Structure (BIDS) is a BRAIN initiative (R24 MH114705)
community-driven standard meant to maximize neuroimaging data sharing, and facilitate analysis tool
development.
TitleA Computational Framework for Distributed Registration of Massive Neuroscience Images
Investigator
Matthew Mccormick
Institute
kitware, inc.
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Neuroscience stands at the precipice of a new depth of understanding about how the brain works thanks to recent
advances in imaging data acquisition technologies such as light-sheet fluorescence microscopy (LSFM).
TitleA Genetic Engineering Toolbox for Marmosets (GETMarm): Development and optimization of genome editing and assisted reproduction techniques for marmoset models
Investigator
Guoping Feng
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
While mice are essential models for many areas of neuroscience, there are also many aspects of
higher brain function and dysfunction that cannot be adequately modeled in rodents. Thus, there is a need for
new genetic models that have brain structure and function closer to humans.
TitleA harmonized vendor-agnostic environment for multi-site functional MRI studies
Investigator
Jon-Fredrik Nielsen, Maxim Zaitsev
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
Since its invention in the early 90s, functional magnetic resonance imaging (fMRI) has revolutionized our un-
derstanding of the human brain. Functional MRI may be used to observe brain function during a specific motor
or cognitive task, or at “rest” (resting-state fMRI).
TitleA web-based framework for multi-modal visualization and annotation of neuroanatomical data
Investigator
David Kleinfeld, Samuel Sheng-Hung Wang
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Modern experimental approaches allow researchers to collect a variety of whole-brain data from the same animal
via different anatomical labels, including tracers, genetic markers, and fiducial marks from recording electrodes.
Unfortunately, viewing and analysis methods have
TitleAcute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy
Investigator
Nuri Firat Ince
Institute
university of houston
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
High frequency oscillations (HFOs) of intracranial EEG (iEEG) have the potential to identify the surgical resection
area/seizure onset zone (SOZ) in patients with drug resistant epilepsy.
TitleAdvancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format
Investigator
Anton Arkhipov, Emad Tajkhorshid
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format
One of the major goals of the BRAIN Initiative is to distill complex, multi-modal data into predictive frameworks
via theory/modeling.
TitleAdvancing brain health research through male germline editing in marmosets
Investigator
Brian Peter Hermann, Jenny Hsieh, John R Mccarrey, Christopher Navara
Institute
university of texas san antonio
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
Neuropsychiatric disorders represent a leading cause of disability, affecting nearly 19% of the US population.
Only 9% of neuropsychiatric drugs entering clinical trials reach the market, which is one of the lowest success
rates across all therapeutic areas.
TitleAdvancing Standardization of Neurophysiology Data Through Dissemination of NWB
Investigator
Benjamin K Dichter, Oliver Ruebel
Institute
university of calif-lawrenc berkeley lab
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Lack of standards for neurophysiology data and related metadata is the single greatest impediment to fully
extracting return on investment from neurophysiology experiments.
TitleAn Alignment Framework For Mapping Brain Dynamics and Substrates of Human Cognition Across Species
Investigator
Ting Xu
Institute
child mind institute, inc.
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The non-human primate (NHP) model is critical to the advancement of translational neuroscience, as it allows
researchers to link observations regarding macroscale brain dynamics and cognition in the human to underlying
meso- and microscale phenomena that cannot be fully investigated in huma
TitleAnticipating ethical challenges and disparities in the dissemination of novel neurotechnologies
Investigator
Winston Chiong, Daniel P. Dohan
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
A central goal for the second half of the BRAIN Initiative is to develop new circuit-based treatments for
brain diseases.
TitleBehavioral Analysis and Modeling Core
Investigator
Jonathan William Pillow
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
Summary/Abstract, Core D: Behavioral Analysis and Modeling
This proposal’s overarching goal is to understand how internal states influence decisions and to identify the
underlying neural mechanisms.
TitleBig-Data Electron-microscopy for Novel Community Hypotheses: Measuring And Retrieving Knowledge (BENCHMARK)
Investigator
William R Gray Roncal
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
In an effort to better understand structural organization and anatomy of nervous systems at
unprecedented spatial resolution, recent efforts, including BRAIN Initiative funded projects, have
collected increasingly larger datasets using Electron Microscopy (EM) and X-Ray
Microtomograp
TitleBRAIN Initiative: Assessing development of event-related cortical network dynamics
Investigator
Scott Makeig, Michael Peter Milham, Arnaud Delorme
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The Child Mind Institute’s Healthy Brain Network (HBN) is an ongoing initiative focused on creating and
sharing a biobank of brain and behavioral data now being collected from 10,000 New York City area children
and adolescents (ages 5-21).
TitleBRAIN Viral Vector Services and Distribution Core
Investigator
Kimberly Ritola
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
The BRAIN Viral Vector Service and Distribution Core will serve as a resource for the maintenance,
propagation, and distribution of viral vectors that are used by neuroscientists for neural circuit
identification and manipulation, as well as for preclinical translational studies.
TitleBRAINShare: Sharing Data in BRAIN Initiative Studies
Investigator
Amy L Mcguire, Sameer Anil Sheth
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Data sharing is essential to promote equity and maximize the impact of the significant investment in the BRAIN
Initiative.