Project Summary
The Child Mind Institute’s Healthy Brain Network (HBN) is an ongoing initiative focused on creating and
sharing a biobank of brain and behavioral data now being collected from 10,000 New York City area children
and adolescents (ages 5-21).
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleBRAIN Initiative: Assessing development of event-related cortical network dynamics
Investigator
Scott Makeig, Michael Peter Milham, Arnaud Delorme
Institute
university of california, san diego
Fiscal Year
Funding Opportunities Number
Project Number
TitleBRAIN Viral Vector Services and Distribution Core
Investigator
Kimberly Ritola
Institute
univ of north carolina chapel hill
Fiscal Year
Funding Opportunities Number
Project Number
The BRAIN Viral Vector Service and Distribution Core will serve as a resource for the maintenance,
propagation, and distribution of viral vectors that are used by neuroscientists for neural circuit
identification and manipulation, as well as for preclinical translational studies.
TitleBRAINShare: Sharing Data in BRAIN Initiative Studies
Investigator
Amy L Mcguire, Sameer Anil Sheth
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Data sharing is essential to promote equity and maximize the impact of the significant investment in the BRAIN
Initiative.
TitleCapturing large-scale locus coeruleus single neuron activity in behaving rats with nanoelectronic threads (NETs), an ultra-flexible multi-electrode probe
Investigator
Nelson Totah
Institute
university of helsinki
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
Systems neuroscience has viewed the brainstem noradrenergic nucleus, Locus Coeruleus (LC), as the
source of a global arousal signal, which modulates cognitive functions by altering operations throughout
the entire central nervous system.
TitleCell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
Investigator
Anton Arkhipov, Li-Huei Tsai
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
Patterned sensory stimulation (PSS) is a non-invasive technique for manipulating brain activity and states,
typically employing periodic light flicker or auditory tones presented at regular intervals.
TitleCell type atlasing of whole human brains using HOLiS: an optimized pipeline for staining, clearing, imaging, and analysis
Investigator
Elizabeth M. C. Hillman, Pavel Osten, Zhuhao Wu
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary (Abstract)
Gaining a comprehensive understanding of brain-wide cellular organization in the human brain has long been
recognized as a critical foundation for understanding complex brain functions, including who we are as humans.
In this project we propose to take on this challenge an
TitleCellular and Neural Network Mechanism of Transcranial Electric Stimulation
Investigator
Dominique M Durand
Institute
case western reserve university
Fiscal Year
Funding Opportunities Number
Project Number
Unveiling mechanisms of neural stimulation technologies is an important goal of the Brain Initiative (RFA-NS-20-006).
TitleCellular Mechanisms of Transcranial Magnetic Stimulation in Cerebellar Cortex
Investigator
Padmavathi Sundaram Patel
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Abstract: Our goal is to develop a cellular level understanding of how transcranial magnetic stimulation (TMS)
may activate neurons in the human cerebellum (Cb) using (i) electrophysiological measurements in an in vitro
turtle Cb, (ii) computational modeling of the induced electric (E) fields in the
TitleChanging the neuromodulation game: ultrasound fenestration of the blood brain barrier for noninvasive viral transfection of primate CNS neurons
Investigator
Arnaud Y Falchier, Charles E Schroeder
Institute
nathan s. kline institute for psych res
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Genetic technologies have revolutionized the way scientists can dissect out brain circuitry by inserting G
protein-coupled receptors that enable selective modulation of neurons in target structures.
TitleCharacterization of in vivo neuronal and inter-neuronal responses to transcranial focused ultrasound
Investigator
Bin He
Institute
carnegie-mellon university
Fiscal Year
Funding Opportunities Number
Project Number
Non-invasive neuromodulation approaches have been developed to enable the modulation of neural tissue without necessitating invasive surgical procedures.
TitleCircuit and Cognitive Mechanisms of Striatal Deep Brain Stimulation
Investigator
Alik S Widge
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
Neurostimulation, including invasive methods like deep brain stimulation (DBS), is an increasingly important approach to treating mental illness. It offers the possibility of directly targeting the circuit dysfunctions that produce mental disorders.
TitleCircuit basis of social behavior decision-making in a subcortical network
Investigator
David J Anderson
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
This proposal responds to an FOA (RFA-NS-18-030) calling for 1) “novel approaches to understand neural
circuitry associated with well-defined social behaviors;” 2) Distributed circuits that contribute to the coordination
of motivational states and reward behavior;” 3) “Empi
TitleCircuits underlying threat and safety
Investigator
Donald B Arnold, Scott E Fraser, Nancy Kopell, Carl Kesselman
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
Classical conditioning has been studied in many different animal models, and even in humans. However, the
larval zebrafish with its transparent brain offers a unique opportunity to observe large scale changes in
synaptic structure that accompany this form of learning.
TitleClinical Translation of Targeted and Noninvasive Ultrasonic Propofol Uncaging
Investigator
Raag D Airan
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY .
There are numerous clinical needs for a technology that can modulate nervous system activity noninvasively
and focally, with clinically-relevant spatial and temporal precision, with a robust and predictable mechanism of
action, and that could act on any of the varied modes of neura
TitleCombined Mechanistic and Input-Output Modeling of the Hippocampus During Spatial Navigation
Investigator
Dong Song
Institute
university of southern california
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT ABSTRACT
Large-scale realistic model of neuronal network is a powerful tool for studying neural dynamics and cognitive
functions. It integrates multi-scale neurobiological mechanisms/processes identified through diverse hypotheses
and experimental data into a single platform.
TitleComparative Neuroanatomy at single-neuron resolution
Investigator
Roger L Clem, Peter Rudebeck
Institute
icahn school of medicine at mount sinai
Fiscal Year
Funding Opportunities Number
Project Number
Project summary
Although single neurons occasionally project to a single downstream target, it is more often the case that their
axons collateralize and project to multiple distinct anatomical areas.
TitleComprehensive and multi-resolution mapping of cell morphology and wiring through X-ray holographic nano-tomography
Investigator
Alexandra Teodora Joita Pacureanu, Wei-Chung Allen Lee
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary / Abstract
A fundamental goal in neuroscience is understanding how information is processed in neuronal circuits.
However, the immense complexity of most brain networks has been a significant barrier to progress.
TitleComputational neuroscience of language processing in the human brain
Investigator
Evelina Fedorenko, Robert Mark Richardson
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
TitleConformable, Expandable Neural Interface Device for the developing brain
Investigator
Jennifer Gelinas, Dion Khodagholy
Institute
columbia univ new york morningside
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
A major obstacle to identifying neural network mechanisms responsible for emergence of cognitive function is
insufficient capability to acquire large-scale electrophysiologic signals across the course of brain maturation.
There is urgent need to develop the technology and ex
TitleConnecting late-life depression and cognition with statistical physics based connectomics and sparse Frechet regression
Investigator
Alex Leow, Yichao Wu, Liang Zhan
Institute
university of illinois at chicago
Fiscal Year
Funding Opportunities Number
Project Number
Recently, several lines of evidence have supported that synaptic dysfunction represents one of
the earliest brain changes in Alzheimer’s disease (AD), leading to hyper-excitation in neuronal
circuits.