PROJECT SUMMARY/ABSTRACT
Episodic memories integrate the content of human experience in space and time and constitute the core of one's
identity.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleDecoding and Selective Modulation of Human Memory During Awake/Sleep Cycles
Investigator
Itzhak Fried
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
TitleDefining motor neuron diversity from embryo to adulthood and generating tools for in vivo and in vitro access
Investigator
Tulsi Patel
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY/ABSTRACT
In order to understand neurological diseases, it is essential to identify the affected neuronal cell types,
create model systems that accurately recapitulate normal function and disease phenotypes, and develop tools
that allow cellular manipulations.
TitleDefining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain Stimulation
Investigator
Christopher R Butson, Aysegul Gunduz, Michael S Okun
Institute
university of florida
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Tourette syndrome (TS) is a continuous lifelong condition that is highly prevalent, socially disabling, and in some severe
cases, physically injurious.
TitleDeveloping A Transition MicroElelectrode Array for Large-scale Brain Recording
Investigator
Yantao Fan
Institute
university of utah
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The brain’s functions are determined by its neural circuits, which consist of approximately 85 billion
neuronal cells.
TitleDeveloping cell type-specific enhancers and connectivity mapping pipelines for marmosets
Investigator
Guoping Feng, Partha Pratim Mitra
Institute
massachusetts institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Although genetic tools have dramatically advanced our understanding of brain function, they have
largely been confined to mice.
TitleDevelopment of 3D-FAST Optical Interface for Rapid Volumetric Neural Sensing and Modulation
Investigator
Emily Gibson, Cristin G Welle
Institute
university of colorado denver
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
To further our understanding of the function of neural circuits, there is a need for new tools that can
collect simultaneous measurements from large populations of neurons involved in a common neural
computation and provide precise functional modulation.
TitleDevelopment of a high throughput system for molecular imaging of different cell types in mouse brain tissues
Investigator
Gaurav Chopra, Julia Laskin
Institute
purdue university
Fiscal Year
Funding Opportunities Number
Project Number
Development of a high throughput system for molecular imaging of different cell types in mouse brain
tissues
Mass spectrometry imaging (MSI) is a powerful tool for developing detailed molecular maps of biological
tissues with high specificity and sensitivity.
TitleDiscovering the molecular genetic principles of cell type organization through neurobiology-guided computational analysis of single cell multi-omics data sets
Investigator
Z Josh Huang
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Understanding the biological principles of cell type diversity and organization is necessary for deciphering
neural circuits underlying brain function.
TitleDisentangling hippocampal and cortical contributions to episodic memory
Investigator
Alexa Tompary
Institute
university of pennsylvania
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
This application describes a 5-year plan to investigate the neural dynamics that underpin distortion in memory,
integrating computational modeling approaches with functional neuroimaging (fMRI) and non-invasive brain
stimulation techniques (TMS).
TitleDissecting active neural circuits regulating sensory and affective pain
Investigator
Akihiko Ozawa
Institute
florida atlantic university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Opioids as a pain medication has been the most preferred pain treatments in order to provide quick relief from
severe pain. Decades of opioid abuse have triggered negative impact on pain therapies.
TitleDissecting neocortical field potential dynamics using optical voltage imaging in genetically targeted cell-types
Investigator
Mark J Schnitzer, Ivan Soltesz
Institute
stanford university
Fiscal Year
Funding Opportunities Number
Project Number
Measurements of cortical field potentials are widely used throughout basic and clinical neuroscience, including in electroencephalography (EEG), electrocorticography (ECoG) and local field potential (LFP) recordings.
TitleDissecting sodium appetite circuits in the mammalian brain
Investigator
Yuki Oka
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Internal sodium balance is critical for many physiological functions, including osmoregulation and action
potentials. Deciphering the mechanisms that control sodium intake is essential for understanding the
principles of appetite regulation and sodium homeostasis in the body.
TitleDissecting the role of neuronal-astroglial interactions in sleep homeostasis
Investigator
Ashley Miranda Ingiosi
Institute
washington state university
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Insufficient sleep, sleep disorders, and resulting problems with health and cognition are increasingly common
in the United States.
TitleDissecting the roles of timing in a canonical neural computation
Investigator
Damon Alistair Clark
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary [30 lines max]
Timing is critical to neural processing. Nowhere is that clearer than in visual motion detection. To detect
motion, neurons transmit visual information with different latencies, or delays, allowing the circuit to compare
visual scenes over time.
TitleEffects of abnormal early experience on IT circuitry
Investigator
Margaret S Livingstone
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The goal of the proposed research is to probe object-recognition circuitry in inferotemporal cortex by specific
manipulations of early visual experience.
TitleEngineered AAV Identification, Validation, and Dissemination Pipeline for Brain Cell Type-Specific Manipulation Across Species
Investigator
Andrew S Fox, Viviana Gradinaru, Timothy Francis Shay, Lin Tian
Institute
california institute of technology
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY:
This team initiative will provide the broad neuroscience community with a cell type-specific adeno-
associated virus (AAV) armamentarium for easy and non-invasive implementation of novel and
emerging molecular tools for anatomical and functional analysis of the nervous system in rod
TitleEnhancing the spatial control of non-invasive brain stimulation by magnetic temporal interference
Investigator
John Gustaf Wilhelm Samuelsson
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Electromagnetic brain stimulation is a safe and proven way of controlling neural activity non-invasively with no
implanted hardware or injected biochemical agents.
TitleEthical and Policy Aspects of Cortical Visual Prosthetics Research: An Empirical Neuroethics Study
Investigator
Peter David Zuk
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Brain-computer interfaces (BCIs) have emerged as a promising modality for restoring physiological functions
such as mobility, communication, and visual perception.
TitleEthologically relevant short term memory in the olfactory bulb
Investigator
Matthew C Smear
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Short-term memory is an essential component of cognition. Here, we will investigate an ethologically
relevant form of short-term memory that guides navigation behavior: memory of odor concentration across
sniffs.
TitleFlexible normalization in ferret V1: computational modeling and 2-photon imaging
Investigator
Theoden I Netoff, Cheryl A. Olman, Gordon Brawn Smith
Institute
university of minnesota
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The remarkable efficiency of human perception derives from the fact that we do not process each stimulus as a
novel event. Instead, past experiences and scene context inform internal, working models of the world that
allow us to generate predictions for our physical environment.