Summary
Invasive neurostimulation is an established technique in the therapy of movement disorders and epilepsy, and
shows promise for amelioration of psychiatric and cognitive disorders.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleAccelerating Dissemination of Implantable Neurotechnology for Clinical Research
Investigator
David Allenson Borton, Timothy Denison, Philip Andrew Starr, Gregory A Worrell
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
TitleActive sensing at the sensory surface: glomerular signals for olfactory navigation by freely-moving mice
Investigator
Matthew C Smear
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
Our senses aren’t passive. Rather, we actively seek relevant information via sampling movements.
However, experiments in sensory systems often restrict sampling movements to simplify stimulus delivery
and allow large scale imaging and electrophysiology.
TitleActivity-dependent mechanisms for memory circuit maturation.
Investigator
Sarah Leinwand
Institute
university of california berkeley
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Adult behavior is the product of neural circuits that have been sculpted during development by
genetic programs and experience in the form of neural activity.
TitleAdaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers In Sleep Dysregulation and Repair
Investigator
Aviva Abosch, Casey Harrison Halpern, Clete A Kushida, John A Thompson
Institute
university of nebraska medical center
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Parkinson’s disease (PD) is a neurodegenerative disorder that leads to both motor and non-motor symptoms.
While there is as yet no cure for PD, medical and surgical therapies have been developed that effectively target
the motor symptoms of PD.
TitleAn Ethical Approach to Detecting Covert Consciousness
Investigator
Michael J Young
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Alarming shortcomings of the bedside behavioral examination in reliably detecting consciousness generate
profound dilemmas for clinicians and families facing decisions about continuation of life-sustaining therapy, pain
control, prognostication, and resource allocation in patients wi
TitleAn integrated platform for studying sensory networks in the vertebrate brain
Investigator
Ethan Kime Scott
Institute
university of queensland
Fiscal Year
Funding Opportunities Number
Project Number
7. Project Summary/Abstract
Human experience is shaped by our senses, which receive diverse inputs from our
environment. These varied inputs, however, all contribute to a single integrated
representation in our minds of the outside world.
TitleApplication of the principle of symmetry to neural circuitry: From building blocks to neural synchronization in the connectome
Investigator
Hernan Makse, Manuel Zimmer
Institute
city college of new york
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
The broad, long-term objective of this grant is to advance a new theoretical approach to identify
synchronized building blocks of neural circuits based on group theory and its application to understand the
permutation symmetries of these circuits.
TitleBicoastal Marmoset Breeding Center
Investigator
Xiaoqin Wang
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The common marmoset (Callithrix jacchus) has experienced unprecedented growth in research across the
United States and is rapidly emerging as a likely keystone biomedical model system in the next chapter of
scientific discovery.
TitleBidirectional Interactions of Cortex and Basal Ganglia During Action Selection
Investigator
Allison Elizabeth Girasole
Institute
harvard medical school
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Selecting future actions based on previous experiences is key to an animal's survival. This process, known as
action selection, depends on the proper function of cortical and subcortical basal ganglia circuits.
TitleBiology and Biophysics of the Cortical Response to Transcranial Magnetic Stimulation
Investigator
Angel V Peterchev, Marc A Sommer
Institute
duke university
Fiscal Year
Funding Opportunities Number
Project Number
The use of transcranial magnetic stimulation (TMS) as a therapeutic intervention is FDA-cleared for treating
depression, obsessive-compulsive disorder, and migraine, and shows promise for a host of other brain disorders.
The appeal of TMS is its safety, non-invasiveness, and well-established capacit
TitleBiophysical modeling of the functional MRI signal through parametric variations in neuronal activation and blood vessel anatomy using realistic synthetic microvascular networks
Investigator
Grant Hartung
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
The most widespread tool for measuring brain activity noninvasively in humans is functional magnetic resonance
imaging (fMRI), which typically tracks changes in blood flow and oxygenation using the blood-oxygenation-level-
dependent (BOLD) signal.
TitleBrain States and Flexible Behavior
Investigator
Santiago Jaramillo, David Mccormick, Cristopher M Niell
Institute
university of oregon
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
To survive in dynamic environments, the nervous system must be able to generate flexible behavior —
seamlessly weaving together past experience with the present context to achieve future goals.
TitleBrainstem circuits of corticospinal neurons
Investigator
Gordon M Shepherd
Institute
northwestern university at chicago
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
Corticospinal axonal projections are critical for mammalian motor control.
TitleCell type selective viral tools to interrogate and correct non-human primate and human brain circuitry
Investigator
Franck K Kalume, Ed Lein, Boaz Pirie Levi, Jonathan T Ting
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
Abstract:
Many cell types together assemble the functional circuitry of the human brain. For over a century, neuroscientists
have categorized brain cell types by their features, including shape, position, physiology, molecules, and
function.
TitleCentral neuronal circuitry for homeostatic thermoregulation modulated by brain temperature
Investigator
Lily Y Jan
Institute
university of california, san francisco
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Maintenance of body temperature at the optimal level is crucial for survival, and it requires homeostatic
feedback regulation based on monitoring the temperature of internal organs as well as the environment.
Homeostatic thermoregulation in response to changes of brain temp
TitleCharacterizing the structure of motor cortex activity across multiple behaviors for improved brain-machine interfaces
Investigator
Karen Elizabeth Schroeder
Institute
columbia university health sciences
Fiscal Year
Funding Opportunities Number
Project Number
Project Abstract. Candidate and career goals: I am an engineer by training, with a strong background in
neural engineering and the development of motor brain-machine interfaces (BMIs). My career goal is to establish
an independent nonhuman primate (NHP) laboratory with two primary aims.
TitleCircuit and cellular mechanisms underlying hierarchical recruitment of motor neurons.
Investigator
Brandon J Mark
Institute
university of washington
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
A fundamentally important motor pattern for terrestrial animals is walking. Walking requires precise
control of large numbers of motor neurons.
TitleCircuit dynamics of sensorimotor integration and decision making in octopus
Investigator
Galit Pelled
Institute
michigan state university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The goal of this proposal is to identify fundamental sensorimotor circuits associated with
goal-oriented gripping movement by using high-dimensional biological, analytical and robotics
technologies.
TitleCloud-based Software Framework to Simplify and Standardize Real-Time fMRI
Investigator
Jonathan D Cohen, Kenneth A Norman
Institute
princeton university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary: (30 lines of text max)
We propose to create an open-source cloud-based software system for real-time fMRI neurofeedback
experiments.
TitleCollaborative Expansion of Marmoset Colonies for Neuroscience Research
Investigator
Jon E Levine, Jeffrey A. Rogers, Corinna Nicole Ross
Institute
university of wisconsin-madison
Fiscal Year
Funding Opportunities Number
Project Number
Summary
Demand for the common marmoset (Callithrix jacchus) in biomedical research has increased tremendously over
the past five years, as they have emerged as a critical biomedical model system in a variety of study disciplines.
The increased use of marmosets has been most acute in neuroscience, wh