Abstract
In order to fully understand the structural substrates underlying the brain function, it is central to curate
multiple attributes of the same neurons.
Funded Awards
The National Institutes of Health (NIH) BRAIN Initiative funds a wide-variety of research: toolmakers, trainees, individual labs testing new hypotheses, and large, team-based efforts aiming to catalyze neuroscience inquiry forward. Explore NIH BRAIN Initiative funded awards listed below. Click on the project title to learn more about it within NIH RePORTER.
To see more NIH-funded awards and associated publications, please visit the NIH RePORTER.
Title
Investigator(s)
Institution
Fiscal Year
Funding Opportunity #
Project #
TitleDevelopment of a scalable strategy for reconstructing cell-type determined connectome of the mammalian brain
Investigator
Dawen Cai, Meng Cui, Yan Yan, Peng Yin
Institute
university of michigan at ann arbor
Fiscal Year
Funding Opportunities Number
Project Number
TitleDevelopment of multi-color, bright chemigenetic indicators to image synaptic transmission
Investigator
Lin Tian
Institute
university of california at davis
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Activity of the brain across structures is an orchestrated process that spans a broad range of time
and space scales. Highly coordinated communication is what activate responses to stimuli, makes
behavior possible, and generates memories.
TitleDevelopment of the Human Dynamic Neurochemical Connectome Scanner
Investigator
Ciprian Catana
Institute
massachusetts general hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
We seek support to develop and build the next generation 7-Tesla magnetic resonance (MR)-compatible
positron emission tomography (PET) brain scanner with dramatically improved spatiotemporal resolution
(HSTR-BrainPET).
TitleDevelopmental cell census of human and non-human primate brain
Investigator
Nenad Sestan
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
The human brain is a highly complex biological tissue organized into hundreds of regions composed of a myriad
of cell types with distinct molecular, morphological, and physiological properties.
TitleDissecting the neural circuit for discrete cue representation in the Dentate Gyrus
Investigator
Sebnem Nur Tuncdemir
Institute
new york state psychiatric institute dba research foundation for mental hygiene, inc
Fiscal Year
Funding Opportunities Number
Project Number
The goal of this project is to provide the building blocks for an independent research program focused on
the mechanisms by which neural networks incorporate multisensory cues into episodic memories.
Discrimination of different contexts composed of distinct constellations of multisensory cues is a h
TitleDissemination of 3-photon imaging for chronic cellular imaging across species
Investigator
Jack Waters
Institute
allen institute
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
Activity-sensitive fluorescent indicators and microscopy have proven valuable tools for measuring neuronal
activity, but most forms of cellular microscopy can produce images of neurons only near the brain surface and
generally only after removal of tissues overlying the brain surface, such
TitleDistributional reinforcement learning in the brain.
Investigator
Jan Drugowitsch, Naoshige Uchida
Institute
harvard university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The field of artificial intelligence (AI) has recently made remarkable advances that resulted in new and
improved algorithms and network architectures that proved efficient empirically in silico.
TitleDopamine neuronal microcircuits controlling methamphetamine seeking behavior
Investigator
Sergio Dominguez Lopez
Institute
oklahoma medical research foundation
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
This proposal is being submitted to support the transition of Dr. Dominguez-Lopez from mentored trainee to
an independent investigator in the neurobiology of drug addiction, specifically studying the dopamine
microcircuits controlling drug-seeking behavior. Dr.
TitleDynamic Striatal Astrocyte-Neuron Interactions: An Integrated Experimental and Computational Study
Investigator
Marsa Taheri
Institute
university of california los angeles
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary/Abstract
Astrocytes comprise up to half of mammalian brain cells.
TitleEliminating the human factor from stereotaxic surgeries
Investigator
Achim Klug
Institute
popneuron llc
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary:
The main goal of this research project is to develop a new line of new stereotaxic devices for small animal
research that outperforms existing devices in terms of accuracy, reproducibility, and ease of use.
TitleElucidating electrical stimulation induced non-neuronal activity using emerging in vivo imaging technology and electrophysiology
Investigator
Takashi Daniel Yoshida Kozai
Institute
university of pittsburgh at pittsburgh
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Electrical microstimulation has become a mainstay of fundamental neuroscience exploration and an
increasingly prevalent clinical therapy.
TitleEngineering of organoid-based brain circuits
Investigator
Andre Levchenko, Flora M Vaccarino
Institute
yale university
Fiscal Year
Funding Opportunities Number
Project Number
The human induced pluripotent stem cell (hiPSC) technology promises major advances in disease modeling
and personalized medicine.
TitleEstablishing Common Coordinate Framework for Quantitative Cell Census in Developing Mouse Brains
Investigator
James C Gee, Yongsoo Kim, Lydia Lup-Ming Ng
Institute
pennsylvania state univ hershey med ctr
Fiscal Year
Funding Opportunities Number
Project Number
Abstract
Brain development is characterized by a diverse set of cell types that are born and connected into rapidly growing
complex 3D structures across time.
TitleEthics of the Choice of Invasive versus Non-invasive Neurosurgery: Different Stakeholders' Perspectives, Surgical Decision-making, and Impact on Patient Sense of Control
Investigator
Cynthia M. S. Kubu
Institute
cleveland clinic lerner com-cwru
Fiscal Year
Funding Opportunities Number
Project Number
ABSTRACT
A fundamental ethical tenet in medicine is bodily sovereignty, inherent in which is the concept of
control.
TitleFocused ultrasound-mediated disruption of blood plasma protein binding with pharmacological molecules
Investigator
Wonhye Lee
Institute
brigham and women's hospital
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Region-specific enhancement of drug delivery to the brain, without increasing systemic drug dose or actively
disrupting the blood-brain barrier, has been sought after for effective pharmacological treatment of various
central nervous system disorders.
TitleFrom ion channels to graph theory in sensorimotor learning
Investigator
Genevieve Konopka, Daniel Margoliash, Jason Neil Maclean, Todd F Roberts
Institute
university of chicago
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
Mechanistically linking network connectivity and the dynamics of neural networks to variation in the behavior of
individuals is an overarching goal of neuroscience.
TitleFunctional role of the neocortico-rubro-olivo-cerebellar circuit on neocortex-induced cerebellar motor learning
Investigator
Shogo Ohmae
Institute
baylor college of medicine
Fiscal Year
Funding Opportunities Number
Project Number
PROJECT SUMMARY
The cerebellum performs information processing for motor control and various cognitive functions in
cooperation with the cerebral neocortex.
TitleGeneration of viral vectors that use alternative splicing to drive cell type-specific gene expression in the nervous system
Investigator
Seth Blackshaw
Institute
johns hopkins university
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
New tools are urgently needed to selectively target constructs that monitor and manipulate the activity of
individual cell types without having to rely on genetic manipulation.
TitleGenetic access and connectional assays of mouse inhibitory cortical cell types
Investigator
Edward M Callaway
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The function of the nervous system is dependent on complex interactions between networks of neurons
composed of multiple neuron types.
TitleGenetic access to cortical cell types with epigenetic assays and high-throughput, low-cost enhancer screening
Investigator
Edward M Callaway
Institute
salk institute for biological studies
Fiscal Year
Funding Opportunities Number
Project Number
Project Summary
The function of the nervous system is dependent on complex interactions between networks of neurons
composed of multiple neuron types.