Notices of Funding Opportunities

The purpose of this notice is to correct the key dates section of RFA-NS-22-040 "BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed)".

This BRAIN Initiative FOA is to further develop molecular tools of high impact that are targetable to brain cell types for the monitoring and manipulation of neural circuits in experimental animals. This FOA is part of the BRAIN Initiative Armamentarium for Brain Cell Access transformative project. This will support iterative improvement of molecular payloads capable of monitoring and manipulating neural cell activity and that can be delivered to specific brain cell types using targeting technologies.

The NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative intends to issue RFA-EB-22-001, BRAIN Initiative: Transformative Brain Non-invasive Imaging Technology Development. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published in summer 2022 with an expected application due date in fall 2022 This FOA will utilize the UG3/UH3 activity code. Details of the planned FOA are provided below.

This Notice is to announce the availability of an informational webinar video with overview information on program goals, application instructions, and project responsiveness for RFA-NS-22-047, RFA-NS-22-048,and RFA-NS-22-049, which are the initiating FOAs for the BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS) Program. The pre-recorded video is optional and is not required for submission of an application.

The purpose of this notice is to clarify the Eligibility Criteria for NOT-NS-21- 014 "Notice of Special Interest (NOSI): Availability of Administrative Supplements for BRAIN Initiative Awardees to Support Resource Dissemination".

The purpose of this notice is to extend the response date for NOT-NS-22-044 "BRAIN Initiative: Request for Information (RFI) on Industry Collaboration in Development and Dissemination of Non-Invasive Brain Imaging Technologies".

The purpose of this notice is to inform applicants of a change to the Due Dates and Eligibility Criteria for NOT-NS-21-014 "Notice of Special Interest (NOSI): Availability of Administrative Supplements for BRAIN Initiative Awardees to Support Resource Dissemination".

This Request for Information (RFI) is issued by the Institutes and Centers of The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. We are soliciting input on opportunities to facilitate collaborations between academic/clinical researchers and potential commercial partners, to enhance the development and dissemination of non-invasive brain imaging technologies. Input is requested from stakeholders such as academic investigators and industry representatives, and the general public.

This Funding Opportunity Announcement (FOA) supports Specialized Projects to develop current or emerging technologies to generate comprehensive atlases of brain connectivity, with an emphasis on human, non-human primate (NHP), and mouse. Projects validating approaches using other species are also permitted if well justified. Applications may address any aspects of the data collection, analysis, and dissemination pipelines, to enable faster and more cost-effective generation and interpretation of brain-wide wiring diagrams. Projects will offer distinct capabilities and competencies aimed at developing and optimizing current technologies or entirely new and potentially risky approaches. They will be integrated into the BRAIN CONNECTS Network, consisting of other Specialized Projects from this FOA, and Comprehensive Centers from its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.

This Funding Opportunity Announcement (FOA) supports Comprehensive Centers to develop and test technologies that can be scaled to brain-wide atlases of human and non-human primate circuit connectivity. Centers will establish data collection, analysis, and dissemination pipelines to demonstrate the feasibility of mapping region-to-region connectivity with a minimum resolution of individual cells and/or axon fibers. They will demonstrate the significance of the approach within the context of a chosen CNS sub-volume, by testing specific hypotheses relating circuit structure to function. They will also incorporate toolsets and infrastructure for integrating separately collected data from smaller volumes, as well as from other data collection modalities, and for enabling the neuroscience community to interact with and mine the data for new research questions. Centers will be integrated into the BRAIN CONNECTS Network, consisting of projects from this FOA and its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.