Notices of Funding Opportunities

Notice Change Application Types Allowed RFA-NS-18-021 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UG3/UH3 Clinical Trial Required)" Notice Number: NOT-NS-19-072 Key Dates Release Date: June 28, 2019 Related Announcements RFA-NS-18-021 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Deafness Other Communication Disorders NIDCD) Purpose purpose this notice to inform applicants revision applications be accepted response RFA-NS-18-021 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UG3/UH3 Clinical Trial Required)". Changes listed below bold italics). notice be effective the October 21, 2019 due date subsequent due dates. Currently Reads: Section II. Award Information Application Types Allowed? New Resubmission Modified Read: Section II. Award Information Application Types Allowed New Resubmission Revision other aspects this FOA remain unchanged.? Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: nick.langhals@nih.gov

Notice Change Application Types Allowed RFA-NS-18-022 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System U44 Clinical Trial Required)" Notice Number: NOT-NS-19-073 Key Dates Release Date: June 28, 2019 Related Announcements RFA-NS-18-022 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Deafness Other Communication Disorders NIDCD) Purpose purpose this notice to inform applicants revision applications be accepted response RFA-NS-18-022 BRAIN Initiative: Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System U44 Clinical Trial Required)". Changes listed below bold italics). notice be effective the October 21, 2019 due date subsequent due dates. Currently Reads: Section II. Award Information Application Types Allowed? New Resubmission Modified Read: Section II. Award Information Application Types Allowed New Resubmission Revision other aspects this FOA remain unchanged.? Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: nick.langhals@nih.gov

Notice Change Application Types Allowed RFA-NS-18-023 BRAIN Initiative: Clinical Studies Advance Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UH3 Clinical Trial Required)" Notice Number: NOT-NS-19-074 Key Dates Release Date: June 28, 2019 Related Announcements RFA-NS-18-023 Issued National Institute Neurological Disorders Stroke NINDS)National Institute Deafness Other Communication Disorders NIDCD) Purpose purpose this notice to inform applicants revision applications be accepted response RFA-NS-18-023 BRAIN Initiative: Clinical Studies Advance Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System UH3 Clinical Trial Required)". Changes listed below bold italics). notice be effective the October 21, 2019 due date subsequent due dates. Currently Reads: Section II. Award Information Application Types Allowed? New Resubmission Modified Read: Section II. Award Information Application Types Allowed New Resubmission Revision other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Nick Langhals, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: nick.langhals@nih.gov

Notice Intent Publish Funding Opportunity Announcement BRAIN Initiative: Proof Concept Development Early Stage Next Generation Human Brain Imaging R01 Clinical Trial Allowed) Notice Number: NOT-EB-19-010 Key Dates Release Date:May 09, 2019 Estimated Publication Date Funding Opportunity Announcement: June 03, 2019 First Estimated Application Due Date: September 03, 2019 Earliest Estimated Award Date: 20, 2020 Earliest Estimated Start Date: July 01, 2020 Related Announcements RFA-EB-17-003 Issued National Institute Biomedical Imaging Bioengineering NIBIB) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose NIH Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative intends reissue RFA-EB-17-003, Proof Concept Development Early Stage Next Generation Human Brain Imaging R01 Clinical Trials Allowed), modifications. funding opportunity aims support early stage development entirely new novel noninvasive human brain imaging technologies methods will lead transformative advances our understanding the human brain. FOA solicits unusually bold potentially transformative approaches supports small scale, proof concept development based exceptionally innovative, original and/or unconventional concepts. FOA utilize R01 activity code. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. Notice encourages investigators expertise insights this area noninvasive human brain imaging technologies methods begin consider applying this new FOA. Research Initiative Details TBD Funding Information Estimated Total Funding TBD Expected Number Awards TBD Estimated Award Ceiling TBD Primary CFDA Numbers TBD Anticipated Eligible Organizations Public/State Controlled Institution Higher Education Private Institution Higher Education Nonprofit 501(c)(3) IRS Status than Institution Higher Education) Nonprofit without 501(c)(3) IRS Status than Institution Higher Education) Small Business For-Profit Organization than Small Business) State Government Indian/Native American Tribal Government Federally Recognized) County governments City township governments Special district governments Independent school districts Public housing authorities/Indian housing authorities Indian/Native American Tribally Designated Organization Native American tribal organizations than Federally recognized tribal governments) U.S. Territory Possession Indian/Native American Tribal Government than Federally Recognized) Non-domestic non-U.S.) Entity Foreign Organization) Regional Organization Eligible Agencies the Federal Government Applications not being solicited this time.  Inquiries Please direct inquiries to: Shumin Wang, PhDNational Institute Biomedical Imaging Bioengineering NIBIB)301-594-9001shumin.wang@nih.gov

Notice Intent Publish Funding Opportunity Announcement BRAIN Initiative: Development Next Generation Human Brain Imaging Tools Technologies U01 Clinical Trial allowed) Notice Number: NOT-EB-19-011 Key Dates Release Date: 09, 2019 Estimated Publication Date Funding Opportunity Announcement: June 03, 2019 First Estimated Application Due Date: September 03, 2019 Earliest Estimated Award Date: 20, 2020 Earliest Estimated Start Date: July 01, 2020 Related Announcements RFA-EB-17-004 Issued National Institute Biomedical Imaging Bioengineering NIBIB) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose NIH Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative intends reissue RFA-EB-17-004, Development Next Generation Human Brain Imaging Tools Technologies U01 Clinical Trials Allowed), modifications. funding opportunity aims support full development entirely new next generation noninvasive human brain imaging tools methods will lead transformative advances our understanding the human brain. FOA seeks innovative applications are ready full-scale development breakthrough technologies the intention delivering working tools. FOA utilize U01 activity code. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. Notice encourages investigators expertise insights this area noninvasive human brain imaging technologies methods begin consider applying this new FOA. Research Initiative Details TBD Funding Information Estimated Total Funding TBD Expected Number Awards TBD Estimated Award Ceiling TBD Primary CFDA Numbers TBD Anticipated Eligible Organizations Public/State Controlled Institution Higher Education Private Institution Higher Education Nonprofit 501(c)(3) IRS Status than Institution Higher Education) Nonprofit without 501(c)(3) IRS Status than Institution Higher Education) Small Business For-Profit Organization than Small Business) State Government Indian/Native American Tribal Government Federally Recognized) County governments City township governments Special district governments Independent school districts Public housing authorities/Indian housing authorities Indian/Native American Tribally Designated Organization Native American tribal organizations than Federally recognized tribal governments) U.S. Territory Possession Indian/Native American Tribal Government than Federally Recognized) Non-domestic non-U.S.) Entity Foreign Organization) Regional Organization Eligible Agencies the Federal Government Applications not being solicited this time   Inquiries Please direct inquiries to: Shumin Wang, PhDNational Institute Biomedical Imaging Bioengineering NIBIB)shumin.wang@nih.gov

Notice Change Key Dates RFA-NS-18-014 BRAIN Initiative: Targeted BRAIN Circuits Planning Projects - TargetedBCPP R34 Clinical Trial Allowed)" Notice Number: NOT-NS-19-034 Key Dates Release Date: April 18, 2019 Related Announcements RFA-NS-18-014 Issued National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Office Behavioral Social Sciences Research OBSSR) Office Research Women’s Health ORWH) Purpose purpose this Notice to inform applicants a change the Key Dates RFA-NS-18-014 Targeted BRAIN Circuits Planning Projects - TargetedBCPP R34 Clinical Trial Allowed)". Three new receipt dates been added the FOA: November 6, 2019, July 1, 2020,and November 10, 2020. Additionally, Peer Review Contact changed Alexei Kondratyev, Ph.D. Currently Reads: Part 1. Overview Information Key Dates Application Due Date(s) March 15, 2018; July 17, 2018; July 15, 2019 Scientific Merit Review June 2018; October 2018; October 2019 Advisory Council Review August 2018; January 2019; January 2020 Earliest Start Date September 2018; April 2019; April 2020 Expiration Date July 16, 2019 Modified Read: Part 1. Overview Information Key Dates Application Due Date(s) March 15, 2018; July 17, 2018; July 15, 2019; November 6, 2019; July 1, 2020; November 10, 2020 Scientific Merit Review June 2018; October 2018; October 2019; February 2020; October 2020; February 2021 Advisory Council Review August 2018; January 2019; January 2020; May 2020; January 2021; 2021 Earliest Start Date September 2018; April 2019; April 2020; June 2020; February 2021; June 2021 Expiration Date November 10, 2021 Currently Reads: Section II. Award Information Funds Available Anticipated Number Awards BRAIN Initiative partner componentsintend commit estimated total 2.5M fund 10 awards. Modified Read: Section II. Award Information Funds Available Anticipated Number Awards BRAIN Initiative partner componentsintend commit estimated total 2.5M fund 10 awards for FY21.   Currently Reads: Section VII. Agency Contact(s) Scientific/Research Contact(s) James Gnadt, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email:BRAINCircuits@NIH.GOV Peer Review Contact(s) Nick Gaiano, PhD Center Scientific Review CSR) Telephone: 301-435-1033 Email:nick.gaiano@nih.gov Modified Read: Section VII. Agency Contact(s) Scientific/Research Contact(s) Karen K David, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email:BRAINCircuits@NIH.GOV Peer Review Contact(s) Alexei Kondratyev, Ph.D. Center Scientific Review CSR) Telephone: 301-465-1785 Email: alexei.kondratyev@nih.gov other aspects this FOA remain same. Inquiries Please direct inquiries to: Karen K David, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: BRAINCircuits@nih.gov

Notice Data Sharing Policy the BRAIN Initiative Notice Number: NOT-MH-19-010 Key Dates Release Date:January 22, 2019 Related Announcements RFA-EY-18-001 RFA-MH-18-510 RFA-MH-19-135 RFA-MH-19-136 RFA-MH-19-147 RFA-MH-19-400 RFA-NS-18-018 RFA-NS-18-019 RFA-NS-18-020 RFA-NS-18-021 RFA-NS-18-022 RFA-NS-18-023 RFA-NS-18-030 RFA-NS-19-001 RFA-NS-19-002 RFA-NS-19-003 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy ShriverNational Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this notice to inform prospective applicants current awardees a new policy concerning data collected support awards are funded the BRAIN Initiative. Specifically, Notice clarifies expectation applicants BRAIN Initiative funding opportunity announcements: 1) submit data one the BRAIN data archives sharing; 2) include specific required elements the Resource Sharing Plan further detailed below; 3) include costs attributed data preparation submission a data archive grant applications. BRAIN Initiative Overview Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative aimed revolutionizing our understanding the human brain. accelerating development application innovative technologies, researchers be able produce new dynamic picture the brain that, the first time, show individual cells complex neural circuits interact both time space. is expected the application these new tools technologies ultimately lead new ways treat prevent brain disorders. NIH one several federal agencies involved the BRAIN Initiative. Planning the NIH component the BRAIN initiative guided the long-term scientific plan, BRAIN 2025: Scientific Vision," details seven high-priority research areas calls a sustained federal commitment 4.5 billion over 12 years. Notice related FOAs issued part the BRAIN initiative based careful consideration the NIH the recommendations the BRAIN 2025 Report, input the NIH BRAIN Multi-Council Working Group. Videocasts the NIH BRAIN Multi-council Working Group available athttp://www.braininitiative.nih.gov/about/mcwg.htm. enable rapid progress development new technologies well in theory data analysis, BRAIN Initiative encourages collaborations between neurobiologists scientists statistics, physics, mathematics, engineering, computer information sciences. BRAIN Initiative Data Sharing BRAIN 2025 report calls establishing platforms sharing data related the BRAIN Initiative. response, NIH released RFAs related data archives RFA-MH-19-145andRFA-MH-17-255), data standards RFA-MH-19-146andRFA-MH-17-256), software integrate analyze data RFA-MH-19-147andRFA-MH-17-257). of those efforts focused data a sub-domain are usually defined the data collection methodology. Data archives have established include: 1) Neuroscience Multi-omic Data Archive https://nemoarchive.org/about.php, R24MH114788) hold data omics experiments. 2) Brain Image Library http://www.brainimagelibrary.org/index.html, R24MH114793) hold microscopy data. 3) Data Archive the BRAIN Initiative https://dabi.loni.usc.edu, R24MH114796) hold data related human electrophysiology experiments. 4) OpenNeuro https://openneuro.org/, R24MH117179) hold magnetic resonance imaging data. 5) Block Object Storage Service https://bossdb.org/, R24MH114785) hold electron microscopy data. few additional data archives distinct sub-domains expected be funded. complete list BRAIN Initiative infrastructure awards be foundhere. awardees the RFAs listed above creating informatics infrastructure necessary BRAIN Initiative awardees others share data are collecting the research community. BRAIN Initiative applications both new resubmissions) submitted after March 1, 2020, applicants required share data collect using BRAIN Initiative informatics infrastructure both data archives relevant data standards),consistent authorities under 21st Century Cures Act these awards authorized under Act. . BRAIN Initiative fellowship applications using any the F activity codes) not required share data are collecting, they encouraged use informatics infrastructure part their training activities. general expectation that data BRAIN Initiative awards be submitted the archives every 6 months. Submitting data an archive distinct sharing data the research community. Submitted data generally held a private enclave until data shared the research community. Frequent submission allows those measuring data perform quality control checks the data deposited. Submitting data an ongoing basis often easier trying package data the end an award period. After data been submitted the appropriate data archive, will shared the research community papers using data been published at end the award period, whichever occurs sooner. calendar submitting data the relevant archive sharing data the research community depend the exact details the experiments are being conducted. applications BRAIN Initiative FOAs required include Resource Sharing Plan part the application. Consistent authorities under 21st Century Cures Act these awards authorized under Act, t portion that plan dealing data must include: 1) summary the data will shared 2) description the standard(s) will used describe data set 3) data archive(s) will house data 4) proposed timeline submitting data the archive sharing data the research community. applications involve human subjects, Resource Sharing Plan should a description whether how consents will used obtain data affect research can done that data. Consents would allow data be used General Research are appropriate all experiments, applicants should consents allow broad data sharing whenever possible. resource sharing plan required matter level funding requested. Costs associated preparing submitting data a data archive should included grant applications. BRAIN Initiative awardees have received awards prior the effective date this Notice encouraged share data. awards prior the effective date this Notice, administrative supplements be necessary prepare such data sets submission an appropriate repository. Investigators should discuss such supplements their assigned program officer. existing BRAIN Initiative awardees already data sharing expectations part their awards. Notice does alter existing data sharing expectations milestones. Inquiries Please direct inquiries to: technical assistance data submission, please contact relevant data archive. other inquiries please contact: Ming Zhan, Ph.D. National Institute Mental Health NIMH) Telephone: 301-827-3678 E-mail:ming.zhan@nih.gov

Notice Correction Key Dates RFA-NS-19-002 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Required)" Notice Number: NOT-NS-19-018 Key Dates Release Date: November 8, 2018 Related Announcements RFA-NS-19-002 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform potential applicants changes Advisory Council Review  Dates RFA-NS-19-002 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Required)". Part 1. Overview Information Key Dates Currently Reads: Advisory Council Review 2018, 2019 May 2020 Modified Read: Advisory Council Review 2019, 2020 and May 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: James Gnadt, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: BRAINCircuits@nih.gov  

Notice Correction Key Dates RFA-NS-19-003 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Allowed)" Notice Number: NOT-NS-19-019 Key Dates Release Date: November 8, 2018 Related Announcements RFA-NS-19-003 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform potential applicants corrections the Council Review  Dates RFA-NS-19-003 BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP U19 Clinical Trial Allowed)". Part 1. Overview Information Key Dates Currently Reads: Advisory Council Review 2018, 2019 May 2020 Modified Read: Advisory Council Review 2019, 2020 and May 2021 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: James Gnadt, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: BRAINCircuits@nih.gov

BRAIN Initiative: Notice Support Research the Fundamental Neurobiology Endogenous Opioid Systems Notice Number: NOT-DA-18-046 Key Dates Release Date:October 9, 2018 Related Announcements None Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative aimed revolutionizing neuroscience through development application innovative technologies map neural circuits, monitor modulate activity, understand they contribute thoughts, sensations, emotions behavior.  NIH issued variety Funding Opportunity Announcements FOAs) will support projects apply technologies understand neural circuit function the context specific circuits, resulting a diverse portfolio research the fundamental biology nervous system function.   announcement to inform research community NIH welcomes applications leverage tools technology emerging the BRAIN Initiative towards elucidating mechanisms which endogenous opioid systems regulate sensory processing, affect cognition appropriate the goals requirements specific BRAIN Initiative FOAs.  overuse opioids created public health crisis, the NIH responding this crisis through conventional Institute Center appropriations special programs such the HEAL Initiative .  However, because BRAIN Initiative specifically aims understand neural circuit activity translates sensory, emotional cognitive functions opioids produce effects engaging endogenous opioid circuits normally regulate same functions, BRAIN uniquely positioned advance knowledge this area. Examples research could supported include use the innovative tools technology profile transcriptome methylome opioid-related neurons , live imaging intracellular signaling cascades identify spatiotemporal aspects cellular signaling engaged opioid receptor activation, brain-wide optical imaging cellular activity cell-types engaged opioids under different conditions, changes connectivity network activity across trajectory opioid assessed optical imaging multiplexed high density electrophysiological recording. Because chronic opioid disrupts cognitive functions emotional regulation the extent being risk survival, study the opioid-dependent brain presents unique opportunity discover how  reprogramming neural substrates circuits translates reprogramming motivation, mood decision-making processes. Interested parties should check information goals requirements specific BRAIN FOAs may appropriate, contact Scientific/Program staff listed the text the respective announcements.  For list active upcoming FOAs.  Inquiries Please direct inquiries to: Olivier Berton, PhD National Institute Drug Abuse Telephone: 301) 827-7771 Email: olivier.berton@nih.gov