Neuroscience Research and Technology

Behavioral modeling and optogenetics elucidate mechanisms of subjective, history-dependent decision bias… Advanced transgenic approach improves light-based study of neuronal circuit dynamics… Current state of computational methods in single-cell functional genomics… Sleep promotes communication between association cortices and hippocampus…

Experimentally manipulating neural activity in behaving mice implicates the posterior parietal cortex in history-based decision bias

Miniaturized carbon fiber electrode arrays for intra-nerve recording and stimulation… Reliable measurement and imaging of brain bioenergetics… Emerging medical imaging tool with superior contrast and sensitivity… Improved method for synaptic neural circuit tracing…

Advances in electrode array fabrication improve longevity of nervous system implants

Multiscale structural mapping of mouse hippocampus … Bayesian inference and variability in a songbird model of learning … Single-fluorophore biosensors enable sensitive detection of kinase dynamics …

Integration of gene expression yields comprehensive, multiscale map of mouse hippocampus

Contributions of the basal ganglia to speech production … High-speed volumetric microscopy of freely-moving Drosophila larvae … Identifying functional neuron subclasses with specificity …

Differences in timing and direction of basal ganglia firing accompany speech production

Direct speech synthesis using auditory cortex recordings… Three-photon imaging of adult mouse brains through intact skulls… Tensor component analysis for unraveling complex neural circuit dynamics…

Decoding neural activity into kinematic and acoustic features yields accurate human speech waveforms

Noninvasive neuroimaging technology for BCI neuroprosthetics … Genetically-encoded voltage indicator ArcLight maps synaptic activity … Exploring alienation effects of DBS treatment for depression …

Implementing noninvasive neuroimaging technology for BCI neuroprosthetic device control

Manipulating neural activity while measuring physiology in awake mice … Discovery of the brightest green fluorescent protein homolog to date … Assessing mouse neural dynamics with optoacoustic imaging … Establishing new open cloud services for brain data …

Repeated imaging of awake mice with multiple imaging modalities yields neural, microscopic, and mesoscopic data

BRAIN is collaborating with Addgene to develop a plasmid/virus collection that will showcase and promote the dissemination of the diverse molecular tools developed under the NIH BRAIN Initiative. NIH will be seeking investigators who are interested in having their plasmids/viruses featured in the collection.

In a recent paper published in JAMA Neurology, a collaborative team of ethics and neuroscience experts highlight key ethical issues surrounding neural device research and provide points to consider for researchers and others working in this space.

Coordination of mouse facial behaviors through motor neurons … Untangling neural activity specific to mouse cognition … Novel analysis for understanding human structural connectomes and traits …

Facial Motor Cortex Neurons Orchestrate Mouse Behaviors Via Projections Extending into Trigeminal Premotor Nuclei