Neuroscience Research and Technology

NIH-funded scientists map human brain in unprecedented detail…

New classification of channelrhodopsin identified… Novel tool developed for studying cell lineages in whole organisms… Multi-area two-photon microscope monitors cortico-cortical dynamics…

Researchers discover new, functionally similar but structurally different cation channelrhodopsins.

Advancements in cell classification strategies and steps toward a comprehensive mouse brain cell atlas…

Demonstration of the feasibility of using a fiberless optoelectrode for activating and recording from neurons… New insights into the mechanisms of neurovascular coupling… Chronic in vivo recordings with carbon fiber microelectrodes… In vivo subcellular imaging of voltage and calcium signals…

Newly designed fiberless multi-color optoelectrode for in vivo use

Whole brain mapping of a sensorimotor response in the zebrafish… Novel optogenetics combination to control select cells in deep brain tissue at high resolution… Instability of neurons during stable song behavior in songbirds…

Whole-brain optogenetic mapping of a visual sensorimotor behavior in the larval zebrafish.

Fabrication and testing of implanted magnetic microcoils to stimulate neurons… Optogenetic-induced seizure model to enhance understanding of interneuron roles… New optical technique to identify voltage activity patterns in specific cell types…

Novel implantable magnetic microcoils stimulate cortical cells and consistently drive behavioral responses

BRAIN Initiative team pushes the limits of functional magnetic resonance imaging (fMRI) for human brain… A novel tool to manipulate gene function in specific cell types… Understanding the functional diversity of retinal bipolar cells…

Advancements to functional imaging technique result in ultra-high resolution capture of human cortical columns

Method to overcome light scatter in optical imaging distinguishes moving objects with high fidelity… Novel analysis method improves accuracy of neural network models… Improved imaging technique reveals synaptic transmission at quantal resolution in fruit fly larvae

Phase retrieval methods in optical imaging allow for successful imaging of moving targets through scattered media 

Intracranial electrical recordings and neuro-stimulation of neurosurgical patients have made fundamental contributions to our understanding of vision, speech, decision making, memory, and sensorimotor processing. The use of these methods has burgeoned over the last decade due to technological advances and an increase in the number of patients undergoing neurosurgery for different neurological disorders.

Enhancement of a new DNA-based bioimaging technique… Method allowing near-simultaneous imaging of several thousand neurons in awake behaving mice… Imaging method to overcome biological tissue refractive index inhomogeneity increases large-field-of-view imaging depth… Open-source software package for working with microscopy images boosts high-throughput, single-cell analysis …

Improved DNA conjugation method enhances the achievable labeling density and spatial accuracy of highly multiplexed Exchange-PAINT imaging